A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

468

Participants

Timeline

Start Date

February 17, 2021

Primary Completion Date

January 11, 2024

Study Completion Date

February 27, 2026

Conditions
Non-small Cell Lung CancerRecurrent Non-small Cell Lung CancerMetastatic Non-small Cell Lung Cancer
Interventions
BIOLOGICAL

Nivolumab

Specified dose on specified days

BIOLOGICAL

Relatlimab

Specified dose on specified days

DRUG

Carboplatin

Specified dose on specified days. Participant will receive only two of the listed chemotherapies (carboplatin, cisplatin, paclitaxel, nab-paclitaxel) along with immunotherapy.

DRUG

Cisplatin

Specified dose on specified days. Participant will receive only two of the listed chemotherapies (carboplatin, cisplatin, paclitaxel, nab-paclitaxel) along with immunotherapy.

DRUG

Paclitaxel

Specified dose on specified days. Participant will receive only two of the listed chemotherapies (carboplatin, cisplatin, paclitaxel, nab-paclitaxel) along with immunotherapy.

DRUG

Nab-Paclitaxel

Specified dose on specified days. Participant will receive only two of the listed chemotherapies (carboplatin, cisplatin, paclitaxel, nab-paclitaxel) along with immunotherapy.

DRUG

Pemetrexed

Specified dose on specified days. Participant will receive only two of the listed chemotherapies (carboplatin, cisplatin, paclitaxel, nab-paclitaxel) along with immunotherapy.

Trial Locations (125)

0

Local Institution - 0079, Santiago

4

Local Institution - 0133, Elm Park

1090

Local Institution - 0126, Vienna

2000

Local Institution - 0029, Rosario

2050

Local Institution - 0055, Camperdown

2250

Local Institution - 0086, Gosford

2340

Local Institution - 0132, Tamworth

3128

Local Institution - 0141, Box Hill

3199

Local Institution - 0109, Frankston

3350

Local Institution - 0130, Ballarat

3550

Local Institution - 0138, Bendigo

3844

Local Institution - 0053, Harderwijk

4031

Local Institution - 0015, Basel

5006

Local Institution - 0060, Córdoba

5087

Local Institution - 0057, Adelaide

5800

Local Institution - 0037, Río Cuarto

6009

Local Institution - 0085, Nedlands

6150

Local Institution - 0119, Murdoch

6815

Local Institution - 0158, Arnhem

8036

Local Institution - 0090, Graz

8500

Local Institution - 0039, Viedma

8800

Local Institution - 0125, Roeselare

9000

Local Institution - 0127, Ghent

Local Institution - 0131, Ghent

9007

Local Institution - 0104, Sankt Gallen

10016

Local Institution - 0128, New York

10021

Local Institution - 0165, New York

10060

Local Institution - 0028, Candiolo

10461

Local Institution - 0097, The Bronx

11501

Local Institution - 0162, Mineola

12351

Local Institution - 0103, Berlin

13585

Local Institution - 0045, Berlin

13790

Local Institution - 0124, Johnson City

14050

Local Institution - 0070, Mexico City

15006

Local Institution - 0051, A Coruña

15212

Local Institution - 0147, Pittsburgh

16149

Local Institution - 0032, Genova

17604

Local Institution - 0084, Lancaster

20141

Local Institution - 0059, Milan

22927

Local Institution - 0062, Großhansdorf

26506

Local Institution - 0157, Morgantown

27710

Local Institution - 0117, Durham

28041

Local Institution - 0074, Madrid

28046

Local Institution - 0123, Madrid

29011

Local Institution - 0042, Málaga

29607

Local Institution - 0083, Greenville

30607

Local Institution - 0089, Athens

32204

Local Institution - 0153, Jacksonville

33098

Local Institution - 0050, Paderborn

34952

Local Institution - 0011, Port Saint Lucie

35000

Local Institution - 0008, Rennes

35016

Local Institution - 0061, Las Palmas

35043

Local Institution - 0071, Marburg

40241

Local Institution - 0002, Louisville

40503

Local Institution - 0159, Lexington

41013

Local Institution - 0075, Seville

44109

Local Institution - 0155, Cleveland

45136

Local Institution - 0065, Essen

45219

Local Institution - 0156, Cincinnati

46026

Local Institution - 0043, Valencia

50090

Local Institution - 0020, Toluca

53100

Local Institution - 0019, Siena

61122

Local Institution - 0164, Pesaro

64710

Local Institution - 0115, Monterrey

66220

Local Institution - 0013, San Pedro Garza García

66421

Local Institution - 0058, Homburg

67214

Local Institution - 0121, Wichita

68130

Local Institution - 0129, Omaha

72037

Local Institution - 0144, Le Mans

74245

Local Institution - 0108, Löwenstein

75005

Local Institution - 0110, Paris

75014

Local Institution - 0102, Paris

75018

Local Institution - 0035, Paris

75701

Local Institution - 0001, Tyler

78550

Local Institution - 0091, Harlingen

88212

Local Institution - 0030, Ravensburg

91010

Local Institution - 0160, Duarte

92868

Local Institution - 0081, Orange

94160

Local Institution - 0006, Saint-Mandé

95125

Local Institution - 0009, Catania

99208

Local Institution - 0092, Spokane

163045

Arkhangelsk Clinical Oncological Dispensary, Arkhangelsk

197022

LLC Eurocityclinic, Saint Petersburg

197376

FSBI &quot,Research Institute of Influenza named after A.A. Smorodintsev &quot,of the MoH of the Rus, Saint Petersburg

200094

Local Institution - 0012, Craiova

200347

Local Institution - 0052, Craiova

200385

Local Institution - 0017, Craiova

300166

Local Institution - 0069, Timișoara

400015

Local Institution - 0099, Cluj-Napoca

7500713

Local Institution - 0041, Santiago

7500921

Local Institution - 0016, Santiago

06520

Local Institution - 0139, New Haven

04074

Local Institution - 0082, Scarborough

07731

Local Institution - 0152, Howell Township

02903

Local Institution - 0148, Providence

75390-9179

Local Institution - 0149, Dallas

C1426

Local Institution - 0021, Buenos Aires

C1430EGF

Local Institution - 0014, Cuiudad Autonoma de Buenos Aires

X5004FHP

Local Institution - 0038, Córdoba

F5300COE

Local Institution - 0073, La Rioja

59062 000

Local Institution - 0063, Natal

98700-000

Local Institution - 0161, Ijuí

90050-170

Local Institution - 0116, Porto Alegre

91350-200

Local Institution - 0112, Porto Alegre

14784-400

Local Institution - 0107, Barretos

09060-870

Local Institution - 0111, Santo André

20220-410

Local Institution - 0072, Rio de Janeiro

04014-002

Local Institution - 0163, São Paulo

08270-120

Local Institution - 0120, São Paulo

21 000

Local Institution - 0007, Dijon

00009

Local Institution - 0023, Dublin

00144

Local Institution - 0106, Rome

81-519

Local Institution - 0145, Gdynia

20-090

Local Institution - 0036, Lublin

20-093

Local Institution - 0031, Lublin

10-357

Local Institution - 0080, Olsztyn

02-781

Local Institution - 0088, Warsaw

08916

Local Institution - 0137, Badalona

08008

Local Institution - 0024, Barcelona

08025

Local Institution - 0154, Barcelona

08035

Local Institution - 0048, Barcelona

TS4 3BW

Local Institution - 0135, Middlesbrough

NW1 2PG

Local Institution - 0101, London

M20 4BX

Local Institution - 0095, Manchester

LE15WW

Local Institution - 0067, Leicester

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY

NCT04623775 - A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC) | Biotech Hunter | Biotech Hunter