A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,600

Participants

Timeline

Start Date

December 4, 2020

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2030

Conditions
HER2-Positive Primary Breast CancerResidual Invasive Breast Cancer
Interventions
DRUG

DS-8201a

Administered initially as an intravenous (IV) infusion at a dose of 5.4 mg/kg on Day 1 of each 21-day cycle

DRUG

T-DM1

Administered initially as an intravenous (IV) infusion at a dose of 3.6 mg/kg on Day 1 of each 21-day cycle

Trial Locations (481)

4

Saint Vincents University Hospital, Dublin

7

Mater Misericordiae University Hospital, Dublin

112

Koo Foundation Sun Yat-Sen Cancer Center, Beitou

114

Tri-Service General Hospital, Taipei

704

National Cheng Kung University Hospital, Tainan City

1000

Institut Jules Bordet Brussels Belgium, Brussels

1200

Cliniques Universitaires Saint-Luc, Brussels

1426

Instituto Alexander Fleming, Caba

2000

Sanatorio Británico de Rosario, Rosario

2050

Chris O Brien Lifehouse, Camperdown

St John of God Hospital - Bendat Family Comprehensive Cancer Centre (BFCCC), Subiaco

ICO Badalona, Barcelona

2065

Genesis Care Northern Cancer, Saint Leonards

2100

Rigshospitalet, Copenhagen

2500

Southern Medical Day Care Centre, Wollongong

2610

GZA Hospitals Campus Sint- Augustinus, Wilrijk

2650

Antwerp University Hospital, Edegem

2930

Algemeen Ziekenhuis AZ Klina - Borstkliniek, Brasschaat

3000

Peter MacCallum Cancer Centre, Melbourne

UZ Leuven - Campus Gasthuisberg, Leuven

3168

Monash Health, Clayton

3804

Austin Hospital- Olivia Newto-John Cancer and Wellness Centre, Heidelberg

4000

CHU Liege, Liège

5000

Royal Adelaide Hospital, Adelaide

Odense University Hospital, Odense

5300

Centro Oncologico Riojano Integral, Capital

5400

CER San Juan, San Juan

6009

Breast Cancer Research Centre - WA, Nedlands

6100

Hacettepe University Cancer Institute, Ankara

6189

Centre Antoine Lacassagne, Nice

6400

Soenderborg sygehus, Syddanmark

8210

Aarhus University Hospital, Aarhus

9000

UZ Gent, Ghent

Aalborg University Hospital, Aalborg

10001

Hospital Universitario San Pedro de Alcantara, Cáceres

10002

National Taiwan University Hospital NTUH, Taipei

10034

Fakultni nemocnice Kralovske Vinohrady, Prague

10060

Istituto di Candiolo - IRCCS, Candiolo

10101

Pamela Youde Nethersole Eastern Hospital PYNEH, Hong Kong

The University of Hong Kong (HKU) - Queen Mary Hospital (QMH), Pok Fu Lam

10117

Cahrité Campus Mitte, Berlin

10126

A.O.U. Citta della Salute e della Scienza di Torino, Torino

10317

Praxis Dr. med. J. Schilling, Berlin

10367

MediOnko-Institut GbR, Praxisklinik Krebsheilkunde, Berlin

10408

National Cancer Center, Gyeonggi-do

10449

MacKay Memorial Hospital, Taipei

10461

Montefiore Medical Center, The Bronx

11528

General Hospital of Athens Alexandra Clinic, Athens

12002

Consorcio Hospitalario Provincial de Castelló, Castellon

12559

DRK Kliniken Berlin Köpenick, Berlin

13001

Centro de Investigación Clinica Trujillo EIRL, Trujillo

13009

Institut Paoli-Calmettes, Marseille

13125

Helios Klinikum Berlin-Buch, Berlin

13349

Onkologische Schwerpunktpraxis, Berlin

Onkologische Schwerpunktpraxis, Bielefeld

13496

CHA Bundang Medical Center CHA University, Gyeonggi-do

13620

Seoul National University Bundang Hospital, Gyeonggi-do

14467

Klinikum Ernst von Bergmann, Potsdam

15006

Complejo Hospitalario Universitario A Coruña (CHUA), A Coruña

15025

AHN Cancer Insititute at Jefferson, Jefferson Hills

15082

Hospital Nacional Arzobispo Loayza, Lima

15090

AHN Cancer Institute at Wexford, Wexford

15102

UPMC Upper St. Clair, Bethel Park

15146

AHN Cancer Institute at Forbes, Monroeville

UPMC Monroeville, Monroeville

15212

Allegheny General Hospital, Pittsburgh

15213

Magee, Pittsburgh

15215

UPMC St. Margaret, Pittsburgh

15224

AHN Cancer Inst at West Penn, Pittsburgh

15232

UPMC Hillman Cancer Center, Pittsburgh

15237

UPMC Passavant HOA, Pittsburgh

UPMC Passavant OHA, Pittsburgh

15301

UPMC Washington, Washington

15401

UPMC Uniontown, Uniontown

15601

UPMC Arnold Palmer-Mt View, Greensburg

15642

UPMC Arnold Palmer-Norwin, N. Huntingdon

15666

UPMC Arnold Palmer-Mt Pleasant, Mount Pleasant

15706

Complejo Hospitalario Clínico Universitario de Santiago de Compostela (CHUS), Santiago de Compostela

16066

UPMC Passavant Cranberry/North, Cranberry Township

16132

Ospedale Poli SAN MARTINO, Genova

16505

UPMC Erie, Erie

16544

AHN Cancer Inst at St Vincent, Erie

17007

ICO Girona, Girona

17050

UPMC Pinnacle-Ortenzio Cancer Center, Harrisburg

17109

UMPC Pinnacle Pharmacy, Harrisburg

17408

UPMC Pinnacle-Memorial Cancer Center, York

18016

Hospital Universitario Clínico San Cecilio, Granada

18059

Univ-Hospital, Dept Ob/Gyn, Rostock

18435

G.SUND Gynäkologie Kompetenzzentrum, Stralsund

19512

Jilin University JLU - First Affiliated Hospital, Changchun

19611

Reading Hospital, McGlinn Cancer Institute, West Reading

20132

IRCCS Ospedale San Raffaele, Milan

20141

Istituto Europeo di Oncologia, Milan

20251

University Medical Center, Hamburg

20357

Mammazentrum HH am Krankenhaus Jerusalem, Hamburg

20904

Maryland Oncology Hematology, Silver Spring

20910

Holy Cross Hospital, Silver Spring

21000

Centre Georges François Leclerc, Dijon

21237

MedStar Franklin Square Medical Center-Harry and Jeanette Weinberg Cancer Institute, Baltimore

21239

MedStar Franklin Square Cancer Center at Loch Raven Campus, Baltimore

21565

Gachon University Gil Medical Center, Incheon

21702

Frederick Health-James M Stockman Cancer Center, Frederick

22030

Trakya University Medical Faculty, Edirne

22328

Institutul Oncologic Bucuresti IOB, Bucharest

22457

Albertinen Krankenhaus, Hamburg

22908

University of Virginia, Charlottesville

23007

Complejo Hospitalario de Jaen, Jaén

23298

Virginia Commonwealth University Massey Cancer Center, Richmond

23562

UKSH Campus Lübeck, Lübeck

24001

Complejo Asistencial Universitario de León, León

24105

University Hospital Schleswig-Holstein, Kiel

24201

Wellmont Medical Associates Oncology & Hematology, Bristol

25198

Hospital Arnau de Vilanova de Lleida, Lleida

26133

Klinikum Oldenburg AöR, Oldenburg

26335

General Hospital of Patras Agios Andreas, Pátrai

26506

West Virginia University, Morgantown

27000

CIMAB S.A. de C.V, Torreón

27100

ICS Maugeri IRCCS, Pavia

27157

Wake Forest Baptist Medical Center, Winston-Salem

27518

Waverly Hematology Oncology, Cary

27804

UNC Cancer Care at Nash, Rocky Mount

28027

Clinica Universidad De Navarra, Madrid, Madrid

28033

Hospital MD Anderson Cancer Center Madrid, Madrid

28034

Hospital Universitario Ramón y Cajal, Madrid

28040

Hospital Universitario Fundación Jiménez Díaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

28050

HM Sanchinarro (CIOCC), Madrid

28205

Klinikum Bremen Mitte, Bremen

28222

Hospital Universitario Puerta de Hierro de Majadahonda, Madrid

28239

Frauenklinik DIAKO Bremen, Bremen

28922

Hospital Universitario Fundación Alcorcón, Alcorcón

28933

Hospital Universitario Rey Juan Carlos, Móstoles

28938

Hospital Universitario HM Puerta del Sur, Madrid

28942

Hospital Universitario de Fuenlabrada, Madrid

29010

Hospital Universitario Virgen de la Victoria, Málaga

30008

Hospital General Universitario Morales Meseguer, Murcia

30120

Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar

30177

Gynäkologisch-Ontologische Praxis Hannover, Hanover

30559

DIAKOVERE Henriettenstift Frauenklinik, Hanover

31008

Complejo Hospitalario de Navarra, Navarro

31059

Institut Claudius Regaud, Toulouse

31134

Gemeinschaftspraxis Frauenärzte am Bahnhofsplatz, Hildesheim

32100

Azienda ULSS n. 1 Dolomiti, Belluno

32159

SCRI FCS North- Villages East, Lady Lake

32207

Baptist MD Anderson Cancer Center, Jacksonville

32429

Johannes Wesling Klinikum Minden, Hämatologie-Onkologie/Brustzentrum, Minden

32605

SCRI FCS North- Gainesville Cancer Center, Gainesville

32701

SCRI FCS North- Altamonte, Altamonte Springs

32763

SCRI FCS North- Orange City, Orange City

32778

SCRI FCS North- Tavares, Tavares

32792

SCRI FCS North- Winter Park, Winter Park

32806

Orlando Health, Orlando

SCRI FCS North- Orlando Downtown, Orlando

33000

Clinique Tivoli Ducos - Centre dOncologie et de Radiotherapie a Bordeaux, Bordeaux

Institut Bergonie, Bordeaux

33081

Centro di Riferimento Oncologico di Aviano - SOC Oncologia Medica e Prevenzione Oncologica, Aviano

33098

Frauenklinik St. Louise - St. Vincenz- Krankenhaus GmbH, Paderborn

33305

Chang Gung Memorial Hospital CGMH, Taipei

33326

Cleveland Clinic-Weston, Weston

33511

SCRI FCS North- Brandon Cancer Center, Brandon

33607

SCRI FCS North- Tampa Cancer Center, Tampa

33705

SCRI FCS North- St. Anthony's/St. Petersburg, St. Petersburg

SCRI FCS North, St. Petersburg

33761

SCRI FCS North- Mease/Clearwater, Clearwater

33770

SCRI FCS North- Largo/Highland, Largo

33901

SCRI FCS South, Fort Myers

33905

SCRI FCS South- Colonial, Fort Myers

33908

SCRI FCS South- Gladiolus, Fort Myers

33909

SCRI FCS South- North Fort Myers, Cape Coral

33980

SCRI FCS South- Port Charlotte, Port Charlotte

34070

Centre de Cancérologie du Grand Montpellier, Montpellier

34093

Istanbul Medeniyet University Medical Faculty, Istanbul

34102

SCRI FCS South- Naples West, Naples

34117

Elisabethkrankenhaus Kassel, Brustzentrum, Kassel

34119

SCRI FCS South- Naples/Goodlette, Naples

34125

Klinikum Kassel, Kassel

34135

SCRI FCS South- Bonita, Bonita Springs

34211

SCRI FCS South- Lakewood Ranch, Lakewood Rch

34232

SCRI FCS South- Sarasota-Cattleman, Sarasota

34236

SCRI FCS South-Sarasota-Downtown, Sarasota

34292

SCRI FCS South- Venice Healthpark, Venice

34461

SCRI FCS North- Lecanto, Lecanto

34474

SCRI FCS North- Ocala, Ocala

34608

SCRI FCS North- Spring Hill, Spring Hill

34655

SCRI FCS North- New Port Richey, New Port Richey

34761

Orlando Health, Ocoee

35001

Union Hospital of Fujian Medical University, Fuzhou

35042

Centre Eugene Marquis, Rennes

35128

Istituto Oncologico Veneto IRCCS, Padua

35575

Medical Park - Izmir Hastanesi, Izmir

37066

SCRI TO Nashville- Gallatin Tennessee Oncology, PLLC, Gallatin

37067

SCRI TO Nashville- Franklin Tennessee Oncology, PLLC, Franklin

37075

SCRI TO Nashville- Hendersonville Tennessee Oncology, PLLC, Hendersonville

37076

SCRI TO Nashville- Summit Tennessee Oncology, PLLC, Hermitage

37090

SCRI TO Nashville- Lebanon Tennessee Oncology, PLLC, Lebanon

37167

SCRI TO Nashville- Smyrna Tennessee Oncology, PLLC, Smyrna

37203

SCRI TO Nashville- St. Thomas Midtown Tennessee Oncology, PLLC, Nashville

Tennessee Oncology Nashville / Sarah Cannon, Nashville

37205

SCRI TO Nashville- St. Thomas West Tennessee Oncology, PLLC, Nashville

37207

SCRI TO Nashville- Skyline Tennessee Oncology, PLLC, Nashville

37211

SCRI TO Nashville- Southern Hills Tennessee Oncology, PLLC, Nashville

37660

Regional Cancer Center at Indian Path Community Hospital, Kingsport

38108

Studien GbR Braunschweig, Braunschweig

38320

Hospital Universitario de Canarias, San Cristóbal de La Laguna

38642

MVZ Onkologische Kooperation Harz, Goslar

38700

Centre Hosp Univ de Grenoble CHUG, La Tronche

40138

Policlinico S.Orsola-Malpighi SSD Oncologia Medica Addarii, Bologna

SSD Oncologia Medica, Bologna

40207

Baptist Health Louisville, Louisville

40225

Universitätsklinikum Düsseldorf, Klinik für Frauenheilkunde & Geburtshilfe, Düsseldorf

40447

China Medical University Hospital, Taichung

40536

University of Kentucky, Markey Cancer Center, Clinical Research Organization, Lexington

40705

Taichung Veterans General Hospital, Taichung

41009

Hospital Universitario Virgen Macarena, Seville

41013

Hospital Quirón Salud Sagrado Corazón, Seville

Hospital Universtiario Virgen del Rocio, Seville

41061

Brustzentrum Niederrhein, Mönchengladbach

41122

University Hospital of Modena, Modena

41462

Dept. OB/GYN Johanna Etienne Krankenhaus, Neuss

41944

Kyungpook National University Hospital, Daegu

42270

Institut De Cancerologie De La Loire, Saint-Priest-en-Jarez

43204

Hospital Universitario Sant Joan Reus, Reus

44137

Klinikum Dortmund gGmbH, Dortmund

St.-Johannes-Hospital Dortmund, Dept. of Obstetrics/Gynecology, Dortmund

44195

Cleveland Clinic - Hillcrest, Cleveland

Cleveland Clinic-Fairview, Cleveland

Cleveland Clinic, Cleveland

Cleveland Clinic South Pointe, Warrensville Heights

44280

Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara

44360

Institut de cancerologie de l'ouest, Saint-Herblain

44649

St. Anna Hospital Brustzentrum, Witten

45136

Kliniken Essen-Mitte, Klinik für Senologie/ Interdisziplinäres Brustzentrum, Essen

45147

Universitätsklinikum Essen, Frauenklinik, Essen

45659

Oncologianova GmbH, Recklinghausen

45879

Evangelische Kliniken Gelsenkirchen, Gelsenkirchen

46009

Fundación Instituto Valenciano de Oncologia (IVO), Valencia

46010

Hospital Clínico Universitario de Valencia, Valencia

46015

Hospital Arnau de Vilanova de Valencia, Valencia

48013

Hospital Universitario de Basurto, Bilbao

49074

MVZ II der Niels-Stensen-Kliniken, Georgsmarienhütte

49100

Rabin Medical Center, Petah Tikva

50006

Changhua Christian Hospital (CCH), Chang-hua

50009

Hospital Clínico Universitario Lozano Blesa, Zaragoza

50011

The 4th Hospital of Heibei Medical University, Shijiazhuang

50931

Unifrauenklinik Köln - Studienzentrum Gynäkologie, Cologne

50935

St. Elisabeth Hospital, Cologne

51067

Kliniken der Stadt Köln / Brustzentrum Holweide, Cologne

53840

Praxisnetzwerk Hämatologie/Internistische Onkologie, Troisdorf

54000

The Sel of Centre dOncologie de Gentilly, Nancy

54290

Klinikum Mutterhaus, Trier

55131

Department of Obstetrics and Gynecology, Mainz

56068

Institut für Versorgungsforschung in der Onkologie, Koblenz

57085

CHR Metz-Thionville, Metz

58100

Area Vasta Sud Est Sede Operativa Grosseto, Grosseto

Azienda Usl Toscana sud est, Grosseto

59000

Centre Oscar Lambret, Lille

60126

Elmhurst Memorial Hospital- Nancy W. Knowles Cancer Center, Elmhurst

Clinica Oncologica, Ospedali Riuniti Umberto 1, Ancona

60323

Frankfurt University Department of Gynecology and Obstetrics, Frankfurt

60389

Centrum for Haematology and Oncology, Frankurt Am Main

60431

AGAPLESION Markus Krankenhaus, Frankfurt am Main

60540

Edward Cancer Center, Naperville

60585

Edward Cancer Center Plainfield, Plainfield

62500

University Hospital Brno, Brno

64320

Consultorio del Dr. Joaqun Gabriel Reinoso Toledo, Monterrey

65549

St. Vincenz KH Limburg, Limburg

66113

CaritasKlinikum St. Theresia, Saarbrücken

66424

Department of Gyencology and Obstetrics, Saarland University Hospital, Homburg

67033

Strasbourg Europe Cancer Institute, Strasbourg

67346

Onkologische Schwerpunktpraxis Speyer, Speyer

67550

Klinikum Worms gGmbH, Worms

68167

Medzinische Fakultät Mannheim, Universität Heidelberg, Mannheim

69008

Centre Leon Berard, Lyon

69120

Universitäts-Frauenklinik, Magdeburg

70121

Ochsner Clinic Foundation, New Orleans

70124

Istituto Oncologico di Bari, Bari

70433

Ochsner Hematology Oncology North Shore - Covington (West Region), Covington

70805

LSU Health Baton Rouge North Clinic, Baton Rouge

70808

Our Lady of the Lake Physician Group-Medical Oncology, Baton Rouge

70809

Mary Bird Perkins Cancer Center, Baton Rouge

71004

Chi Mei Medical Center CMMC - Yongkang Branch, Tainan City

71065

Klinikverbund Südwest Kliniken Böblingen Frauenklinik Böblingen, Böblingen

71110

University General Hospital of Heraklion, Heraklion

72100

Presidio Ospedaliero di Summa - Antonio Perrino, Brindisi

73730

Klinikum Esslingen GmbH, Esslingen am Neckar

75010

Hospital St Louis, Paris

75015

Hopital Georges Pompidou, Paris

75020

IUC AP-HP. Sorbonne Université, Hôpital Tenon, Paris

76199

ViDia Christliche Kliniken Karlsruhe, Karlsruhe

77030

Houston Methodist, Houston

77058

Houston Methodist Clear Lake, Nassau Bay

77070

Houston Methodist Willowbrook, Houston

77094

Houston Methodist West, Houston

77385

Houston Methodist Woodlands, The Woodlands

77479

Houston Methodist Sugarland, Sugar Land

77521

Houston Methodist Baytown, Baytown

77694

Ortenau Klinikum Offenburg-Kehl, Offenburg

78052

Schwarzwald - Baar Klinikum Frauenklinik, Villingen-Schwenningen

79106

Universitätsklinik Freiburg, Klinik für Frauenheilkunde, Freiburg im Breisgau

80131

INT Fondazione Pascale, Napoli

80637

Rotkreuzklinikum München, Frauenklinik, München

80639

Medizinisches Versorgungszentrum für Hämatologie und Onkologie München MVZ GmbH, München

80756

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

81377

LMU Klinikum/ Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, München

81925

Gynaekologie Arabella, Munich

82445

E-Da Cancer Hospital, Kaohsiung City

83022

RoMed Klinikum Rosenheim, Rosenheim

86021

CHU de Poitiers, Poitiers

86150

Gemeinschaftspraxis Dres. Halder / Bangerter, Augsburg

87700

Klinikum Memmingen, Memmingen

88212

Studienzentrum Onkologie Ravensburg, Ravensburg

89081

Universitätsfrauenklinik Ulm, Ulm

90027

Kaiser Permanente, Los Angeles

90034

Kaiser Permanente, West Los Angeles

90706

Kaiser Permanente, Bellflower

90710

Kaiser Permanente, Harbor City

Kaiser Permanente, Ontario

90806

Long Beach Memorial TCI, Long Beach

91054

Frauenklinik der Universität Erlangen, Erlangen

Frauenklinik, Tübingen

91120

Hadassah Medical Center, Jerusalem

91367

Kaiser Permanente, Woodland Hills

91402

Kaiser Permanente, Panorama City

91706

Kaiser Permanente, Baldwin Park

92078

Kaiser Permanente, San Marcos

92120

Kaiser Permanente, San Diego

92335

Kaiser Permanente, Fontana

92505

Kaiser Permanente, Riverside

92618

Kaiser Permanente, Irvine

92708

Orange Coast Blood and Cancer Care, Fountain Valley

92801

The Oncology Institute of Hope & Innovation, Anaheim

92806

Kaiser Permanente, Anaheim

94469

DONAUISAR Klinikum, Deggendorf

95122

Azienda Ospedaliera Garibaldi-Nesima, Catania

98002

MultiCare Cancer Center Aurburn, Auburn

98335

MultiCare Regional Cancer Center - Gig Harbor, Gig Harbor

98372

MultiCare Cancer Center Puyallup, Puyallup

98405

MultiCare Cancer Center Tacoma, Tacoma

99204

MultiCare Institute for Research & Innovation, Spokane

99218

MultiCare Institute for Research & Innovation, Spokane

100142

Peking University Cancer Hospital, Beijing

100191

Peking University Third Hospital, Beijing

111217

Taipei Veterans General Hospital TPVGH, Taipei

119074

National University Cancer Institute, Singapore

150060

Harbin Medical University Cancer Hospital, Harbin

163045

SBHI Arkhangelsk Region - Arkhangelsk Clinical Oncological Dispensary, Arkhangelsk

169610

National Cancer Center Singapore, Singapore

200032

Fudan University Cancer Hospital, Shanghai

200103

Onco Clinic Consult SA, Craiova

200347

Centrul de Oncologie Sfantu Nectarie, Craiova

210029

Nanjing Medical University NMU - Jiangsu Province Hospital, Nanjing

250117

Shandong Cancer Hospital, Jinan

310002

Zhejiang Cancer Hospital, Hangzhou

310009

Second Affiliated Hospital of Zhejiang University, Hangzhou

330006

Nanchang University - The First Affiliated Hospital, Nanchang

354057

State Budgetary Healthcare Institution Oncological Dispensary No. 2 of the Ministry of Health of Krasnodar Region, Sochi

361003

The First Affiliated Hospital of Xiamen University, Xiamen

400015

Institutul Oncologic Prof. Dr. Ion Chiricuta, Cluj-Napoca

400016

Chongqing Medical University - The First Affiliated Hospital, Chongqing

510030

Sun Yat-sen Memorial Hospital, Guangzhou

510080

Guangdong Academy of Medical Science, Guangzhou

610041

Sichuan University - West China Hospital, Chengdu

999077

The Chinese University of Hong Kong (CUHK) - Prince of Wales Hospital (PWH), Hong Kong

1428666

Showa University Hospital - Breast Center, Shinagawa-Ku

4780000

SIM CRC, Temuco

5262100

Sheba Medical Center, Ramat Gan

7500921

Fundacion Arturo Lopez Perez, Santiago

8380456

Hospital Clinico Universidad de Chile, Santiago

8410101

Soroka MC, Beersheba

15092415

Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto

S2000KZE, 2457

Instituto de Oncología de Rosario, Rosario

B1884BBF

COIBA, Buenos Aires

70200-730

Hospital Sirio-Libanes HSL - Centro de Oncologia - Brasilia, Brasília

81520-060

Hospital Erasto Gaertner, Curitiba

95070-560

Fundação Universidade de Caxias do Sul Instituto de Pesquisas em Saúde IPS-UCS, Caxias do Sul

90610-000

Hospital Sao Lucas PUCRS, Porto Alegre

14784-400

Fundacao Pio XII-Hospital de Cancer de Barretos, Barretos

09060-650

CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia, Santo André

20560-120

INCA - Instituto Nacional do Cancer / Hospital do Cancer HCIII, Rio de Janeiro

01246-000

Instituto do Cancer do Estado de Sao Paulo (ICESP), São Paulo

T2N4N2

Tom Baker Cancer Centre, Calgary

K1H 8L6

The Ottawa Hospital Cancer Centre, Ottawa

H1T 2M4

CIUSSSS de l'Est-de-l'Ile-de-Montréal - Installation Hôpital Maisonneuve-Rosemont, Montreal

H2X3E4

CHUM, Montreal

H3T1E2

Jewish General Hospital Segal Cancer Centre, Montreal

H4A 3J1

McGill University Health Centre - Cedars Cancer Centre, Montreal

G1S 4L8

CHU de Quebec - Hopital du Saint-Sacrement, Québec

85925 cedex 9

CHD Vendee, La Roche-sur-Yon

09116

Klinikum Chemnitz gGmbH, Chemnitz

01067

Onkologische Schwerpunktpraxis, Dresden

01069

University Hospital Dresden, Dresden

01127

Onkozentrum Dresden, Dresden

07548

SRH Waldklinikum Gera, Brustzentrum Ostthüringen, Gera

06110

Krankenhaus St. Elisabeth und St. Barbara Halle/Saale, Halle

04860

KKH Torgau, Torgau

06484

Harzklinikum Dorothea Christiane Erxleben, Wernigerode

265 04

University General Hospital of Patras, Pátrai

D8

St. James Hospital, Dublin

T12 YN60

University College Cork, Cork

V94 F858

University Hospital Limerick, Limerick

06132

Azienda Ospedaliera di Perugia, Perugia

673-8558

Hyogo Cancer Center, Akashi

104-0045

National Cancer Center (NCC) - Tsukiji Campus - National Cancer Center Hospital (NCCH), Chūōku

811-1395

National Hospital Organization - National Kyushu Cancer Center, Fukuoka

730-8518

Hiroshima City Hiroshima Citizens Hospital, Hiroshima

253-0036

Tokai University Hospital - Isehara Campus, Isehara

892-0833

Sagara Hospital, Kagoshima

277-8577

National Cancer Center Hospital East (NCCHE) - Kashiwa Campus, Kashiwa

135-8550

Japanese Foundation for Cancer Research (JFCR) - The Cancer Institute Hospital - Breast Oncology Center, Kōtoku

606-8507

Kyoto University Hospital, Kyoto

791-0280

National Hospital Organization (NHO) - Shikoku Cancer Center, Matsuyama

464-8681

Aichi Cancer Center Hospital, Nagoya

951-8133

Niigata Cancer Center Hospital, Niigata

663-8501

Hyogo College of Medicine Hospital, Nishinomiya

700-8558

Okayama University Hospital, Okayama

540-0006

National Hospital Organization - Osaka National Hospital (ONH), Osaka

541-8567

Osaka International Cancer Institute (OICI), Osaka

362-0806

Saitama Cancer Center, Saitama

003-0804

National Hospital Organization - Hokkaido Cancer Center, Sapporo

589-8511

Kindai University (Kinki University) - Faculty of Medicine (Kinki University School of Medicine (KUSM)) - Kindai University Hospital (Kinki University Hospital) - Cancer Center, Sayama

980-8574

Tohoku University Hospital (TUH) - Clinical Research, Innovation and Education Center (CRIETO), Sendai

160-0023

Tokyo Medical University Hospital, Shinjuku-Ku

411-8777

Shizuoka Cancer Center (SCC), Shizuoka

241-8515

Kanagawa Cancer Center Hospital - Kanagawa Cancer Center (Kanagawa Cancer Centre Research Institute), Yokohama

1081 HZ

Amsterdam UMC - VU Medisch Centrum, Amsterdam

4800 RK

Amphia Hospital Breda, Breda

3000 CA

Erasmus MC - Daniel den Hoed Oncologisch Centrum, Rotterdam

Lima 27

Clinica Ricardo Palma, Lima

Lima 34

Instituto Nacional de Enfermedades Neoplasicas INEN, Lima

61-485

Centrum Medyczne HCP Sp. z o.o., Poznan

45-061

SP Zoz Opolskie Centrum Onkologii IM, Opole

80-211

Uniwersyteckie Centrum Kliniczne, Gdansk

93-338

Instytut Centrum Zdrowia Matki Polki, Lodz

02-781

MSCM Cancer Center and Institute of Oncology Department of Breast Cancer and Reconstructive Surgery, Warsaw

4835-044

Hospital da Senhora da Oliveira, Guimarães EPE, Guimarães

1099-023

Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon

1400-038

Fundação Champalimaud, Lisbon

1449-005

Centro Hospitalar de Lisboa Ocidental, EPE, Lisbon

1500-650

Hospital da Luz, Lisbon

1998-018

Hospital CUF Descobertas, Lisbon

2674-514

Hospital Beatriz Ângelo, Loures

4464-513

Unidade Local de Saúde de Matosinhos, EPE, Matosinhos Municipality

4200-072

Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto

4434-502

Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE, Vila Nova de Gaia

06351

Samsung Medical Center, Irwon-dong

02841

Korea University Anam Hospital, Seoul

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Seoul

05505

Asan Medical Center, Songpa-gu

330-721

Soon Chun Hyang Central Medical Center (SCHMC), Yongsan

03010

Hospital General Universitario de Alicante, Alicante

03550

Hospital de San Juan de Alicante, Alicante

Unknown

Hospital Universitario de Badajoz, Badajoz

08003

Hospital del Mar, Barcelona

08023

IOB Institute Of Oncology-Hospital Quironsalud Barcelona, Barcelona

08035

Hospital Universitari Vall d'Hebron, Barcelona

08036

Hospital Clínic de Barcelona, Barcelona

08221

Hospital Universitari Mútua Terrassa, Barcelona

08243

ALTHAIA, Xarxa Assistencial Universitària de Manresa F.P., Barcelona

08304

Hospital de Mataró, Barcelona

08907

ICO Hospitalet, Barcelona

07120

Hospital Universitari Son Espases, Palma de Mallorca

07198

Hospital Son Llatzer, Palma de Mallorca

08195

Hospital General de Catalunya, Sant Cugat del Vallès

PE3 9NZ

Peterborough City Hospital, Peterborough

ME16 9QQ

Kent Oncology Centre Maidstone Hospital, Maidstone

M20 4XB

The Christie Hospital, Manchester

CH63 4JY

Clatterbridge Cancer Centre, Metropolitan Borough of Wirral

NG5 1PB

Nottingham University Hospitals, Nottingham

BA1 3NG

Royal United Hospital Bath NHS Trust - Royal United Hospital RUH, Bath

TA1 5DA

Somerset NHS Foundation Trust, Taunton

LS9 7TF

St. James University Hospital, Leeds

BS2 8ED

Univeristy Hospitals Bristol NHS Foundation Trust, Bristol

CO4 5JL

Colchester Hospital, East Suffolk & North Essex NHS Foundation Trust, Colchester

EX2 5DW

Royal Devon Exeter NHS Foundation Trust, Exeter

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

SE1 9RT

Guys and St Thomas NHS Foundation Trust, London

W6 8RF

Charing Cross Hospital, London

OX3 7LJ

Oxford University Hospitals NHS Foundation Trust, Oxford

FY3 8NR

Blackpool Victoria Hospital, Peterborough

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

collaborator

NSABP Foundation Inc

NETWORK

collaborator

GBG Forschungs GmbH

OTHER

collaborator

Spanish Breast Cancer Research Group (SOLTI)

UNKNOWN

lead

Daiichi Sankyo

INDUSTRY

NCT04622319 - A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05) | Biotech Hunter | Biotech Hunter