56
Participants
Start Date
December 16, 2020
Primary Completion Date
June 21, 2022
Study Completion Date
June 30, 2024
Atezolizumab
Atezolizumab will be administered by intravenous infusion at a fixed dose of 1200 mg on Day 1 of each 21-day cycle until unacceptable toxicity or loss of clinical benefit as determined by the investigator after an integrated assessment of radiographic and biochemical data, and clinical status.
Cisplatin
Cisplatin will be administered as intravenous infusion at a dose of 75 mg per meter squared (75 mg/m\^2) after completion of atezolizumab on Day 1 of each 21-day cycle during the induction phase (Cycles 1-4).
Carboplatin
Carboplatin will be administered as intravenous infusion at a dose of area under the concentration-time curve (AUC) of 5 mg/mL/min on Day 1 of each 21-day cycle during the induction phase (Cycles 1-4).
Etoposide
Etoposide will be administered intravenously at a dose of 100 mg/m\^2 on Days 1, 2 and 3 of each 21-day cycle during the induction phase (Cycles 1-4).
Thoracic radiation therapy (TRT)
Participants will receive concurrent thoracic radiation therapy (TRT) treatment, in once daily fractions, 3 Gy per fraction, to a target dose of 15 Gy in 5 fractions from Day 1-Day 5 in the first cycle.
Cancer Hospital , Chinese Academy of Medical, Beijing
Shanghai Pulmonary Hospital, Shanghai
Fudan University Shanghai Cancer Center; Medical Oncology, Shanghai
Tianjin Cancer Hospital, Tianjin
Second Affiliated Hospital of Third Military Medical University, Chongqing
Hunan Cancer Hospital, Changsha
Central South Hospital, Wuhan University, Wuhan
West China Hospital - Sichuan University, Chengdu
Hoffmann-La Roche
INDUSTRY