Study of Low-Dose Radiotherapy (LDRT) Concurrent Cisplatin/Carboplatin Plus Etoposide With Atezolizumab for Patients With Extensive-Stage Small Cell Lung Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

56

Participants

Timeline

Start Date

December 16, 2020

Primary Completion Date

June 21, 2022

Study Completion Date

June 30, 2024

Conditions
Carcinoma, Small Cell Lung
Interventions
DRUG

Atezolizumab

Atezolizumab will be administered by intravenous infusion at a fixed dose of 1200 mg on Day 1 of each 21-day cycle until unacceptable toxicity or loss of clinical benefit as determined by the investigator after an integrated assessment of radiographic and biochemical data, and clinical status.

DRUG

Cisplatin

Cisplatin will be administered as intravenous infusion at a dose of 75 mg per meter squared (75 mg/m\^2) after completion of atezolizumab on Day 1 of each 21-day cycle during the induction phase (Cycles 1-4).

DRUG

Carboplatin

Carboplatin will be administered as intravenous infusion at a dose of area under the concentration-time curve (AUC) of 5 mg/mL/min on Day 1 of each 21-day cycle during the induction phase (Cycles 1-4).

DRUG

Etoposide

Etoposide will be administered intravenously at a dose of 100 mg/m\^2 on Days 1, 2 and 3 of each 21-day cycle during the induction phase (Cycles 1-4).

RADIATION

Thoracic radiation therapy (TRT)

Participants will receive concurrent thoracic radiation therapy (TRT) treatment, in once daily fractions, 3 Gy per fraction, to a target dose of 15 Gy in 5 fractions from Day 1-Day 5 in the first cycle.

Trial Locations (8)

100021

Cancer Hospital , Chinese Academy of Medical, Beijing

200433

Shanghai Pulmonary Hospital, Shanghai

201315

Fudan University Shanghai Cancer Center; Medical Oncology, Shanghai

300060

Tianjin Cancer Hospital, Tianjin

400030

Second Affiliated Hospital of Third Military Medical University, Chongqing

410013

Hunan Cancer Hospital, Changsha

430000

Central South Hospital, Wuhan University, Wuhan

610047

West China Hospital - Sichuan University, Chengdu

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT04622228 - Study of Low-Dose Radiotherapy (LDRT) Concurrent Cisplatin/Carboplatin Plus Etoposide With Atezolizumab for Patients With Extensive-Stage Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter