Tomivosertib Combined With Pembrolizumab in Subjects With PD-L1 Positive NSCLC (KICKSTART)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

68

Participants

Timeline

Start Date

June 2, 2021

Primary Completion Date

October 14, 2024

Study Completion Date

December 9, 2024

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

Tomivosertib

Tomivosertib (eFT508) will be taken at 100 mg twice daily (bid) with meals

BIOLOGICAL

Pembrolizumab

Subjects will initiate or continue to receive pembrolizumab at either 200 mg intravenously (IV) at a frequency of every 3 weeks or 400 mg IV at a frequency of every 6 weeks.

DRUG

Pemetrexed

Subjects will initiate pemetrexed at 500 mg/m2 intravenously (IV) at a frequency of every 3 weeks.

Trial Locations (144)

159

JSC Viani, Tbilisi

186

Caucasus Medical Centre LLC, Tbilisi

3350

Ballarat Regional Integrated Cancer Center, Ballarat

4217

Gold Coast Cancer Care - Pindara, Benowa

4600

JSC Vian - Kutaisi Referral Hospital, Kutaisi

5042

Flinders Medical Centre, Bedford Park

6000

High Technology Hospital MedCenter Ltd, Batumi

10032

Columbia University Medical Center, New York

Columbia University, New York

13790

Broome Oncology, LLC (Harrison St), Johnson City

13905

Broome Oncology, Binghamton

20155

Virginia Cancer Specialists, PC (Lake Manassas Dr), Gainesville

20176

Virginia Cancer Specialists, PC (Riverside Pkwy), Leesburg

20613

Maryland Oncology Hematology, P.A. (Matapeake Business Dr), Brandywine

20706

Maryland Oncology Hematology, P.A. (Good Luck Rd), Lanham

20735

Maryland Oncology Hematology, P.A. (Woodyard Rd), Clinton

20817

Maryland Oncology Hematology, P.A. (Rockledge Dr), Bethesda

20850

Maryland Oncology Hematology, P.A. (Medical Center Drive), Rockville

20904

Maryland Oncology Hematology, P.A. (Healing Way), Silver Spring

21044

Maryland Oncology Hematology, P.A, Columbia

21401

Luminus Health Research Institute, Inc., Annapolis

21702

Maryland Oncology Hematology, P.A. (Thomas Johnson Dr), Frederick

22031

Virginia Cancer Specialists, PC, Fairfax

22205

Virginia Cancer Specialists, PC (N George Mason Dr), Arlington

22304

Virginia Cancer Specialists, PC (Kenmore Ave), Alexandria

26506

West Virginia University Cancer Institute, Morgantown

28806

Messino Cancer Center, Asheville

29615

Prisma Health Cancer Institute, Greenville

31904

John B. Amos Cancer Center, Columbus

32503

Woodlands Medical Specialists, PA, Pensacola

32806

University of Florida (UF) Health Cancer Center - Orlando Health, Orlando

32901

Cancer Care Centers of Brevard, Palm Bay

32935

Cancer Care Centers of Brevard (Melbourne), Melbourne

33021

Memorial Healthcare System, Hollywood

33028

Memorial Cancer Institute at Memorial West Hospital, Pembroke Pines

34613

ASCLEPES Research Centers, Brooksville

36526

Southern Cancer Center, Daphne

36607

Southern Cancer Center, PC (Mobile Infirmary Circle), Mobile

36608

Southern Cancer Center, PC (Airport Blvd), Mobile

Southern Cancer Center, PC (Dauphin St), Mobile

40207

Baptist Health - Louisville, Louisville

40503

Baptist Health - Lexington, Lexington

43614

University of Toledo, Toledo

44622

Tri-County Hematology & Oncology Associates, Dover

44646

Tri-County Hematology & Oncology Associates - Massillon, Massillon

44708

Mercy Hematology and Oncology Associates, Canton

44718

Gabrail Cancer Center, Canton

45428

VA Medical Center- Dayton, Dayton

45429

Kettering Medical Center, Kettering

46804

Fort Wayne Medical Oncology and Hematology, Fort Wayne

48202

Henry Ford Hospital, Detroit

55416

Metro Minnesota CCOP, Saint Louis Park

57201

Prairie Lakes Cancer Center, Watertown

59102

St. Vincent Frontier Cancer Center, Billings

63110

Washington University School of Medicine, St Louis

64804

Mercy Cancer Center, Joplin

75010

Texas Oncology-Carrollton (N Josey Lane), Carlton

75028

Texas Oncology - Flower Mound - Carrollton, Flower Mound

75075

Texas Oncology - Plano East, Plano

75231

Texas Oncology - Dallas Presbyterian Hospital, Dallas

75246

Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas

75460

Texas Oncology - Paris, Paris

75601

Texas Oncology - Longview Cancer Center, Longview

75702

Texas Oncology - Tyler, Tyler

75801

Texas Oncology - Palestine, Palestine

76022

Texas Oncology - Bedford, Bedford

76051

Texas Oncology-Grapevine, Grapevine

76104

Texas Oncology - Fort Worth Cancer Center, Fort Worth

76201

Texas Oncology - Denton, Denton

76712

Texas Oncology - Waco, Waco

77024

Texas Oncology - Memorial City, Houston

77030

Oncology Consultants, Houston

77070

Texas Oncology Gulf Coast (Willowbrook), Houston

77598

Texas Oncology Golf Coast - Deke Slayton Cancer Center, Webster

77701

Texas Oncology Gulf Coast - Beaumont (College St), Beaumont

77702

Texas Oncology Gulf Coast - Beaumont Mamie McFaddin Ward Cancer Center, Beaumont

78550

Valley Cancer Associates, Harlingen

78705

Texas Oncology-Austin Midtown (W. 38th St), Austin

78731

Texas Oncology-Austin Central (Balcones Dr.), Austin

78745

Texas Oncology - South Austin, Austin

79761

Texas Oncology - West Texas (Odessa), Odessa

79902

Texas Oncology - West Texas (Grandview Ave), El Paso

Texas Oncology - West Texas, El Paso

79915

Texas Oncology - West Texas (Gateway Blvd E), El Paso

79938

Texas Oncology - West Texas (Joe Battle Dr), El Paso

80012

Rocky Mountain Cancer Centers (South Potomac St), Aurora

80112

Rocky Mountain Cancer Centers (E Arapahoe Rd), Centennial

80124

Rocky Mountain Cancer Centers (Ridge Gate Parkway), Lone Tree

80218

Rocky Mountain Cancer Centers (Williams St), Denver

80220

Rocky Mountain Cancer Centers (E. Hale Parkway), Denver

80228

Rocky Mountain Cancer Centers (West 2nd Place), Lakewood

80260

Rocky Mountain Cancer Centers (Huron St), Thornton

80303

Rocky Mountain Cancer Centers (Arapahoe Ave), Boulder

80504

Rocky Mountain Cancer Centers (E. Ken Pratt Blvd), Longmont

80907

Rocky Mountain Cancer Centers, Colorado Springs

80923

Rocky Mountain Cancer Centers, Colorado Springs CO (Peregrine), Colorado Springs

81008

Rocky Mountain Cancer Centers (Ridge Gate Parkway), Pueblo

85016

Arizona Oncology Associates, PC - HAL, Phoenix

85258

Arizona Oncology Associates (N. Pima Rd), Scottsdale

Arizona Oncology Associates, PC - HAL, Scottsdale

85284

Arizona Oncology Associates, PC - HAL, Tempe

85308

Arizona Oncology Associates, PC - HAL (W Bell Rd), Glendale

85395

Arizona Oncology Associates, PC - NAHOA (W. McDowell), Goodyear

85704

Arizona Oncology Associates, PC - HOPE (W. Orange Grove), Tucson

Arizona Oncology Associates, PC - HOPE (W. Rudasill Rd), Tucson

85711

Arizona Oncology Associates, PC - HOPE, Tucson

85745

Arizona Oncology Associates, PC - HOPE (West St.), Tucson

86314

Arizona Oncology Associates, PC-NAHOA (N. Windsong), Prescott Valley

90025

University of California, Los Angeles (UCLA), Los Angeles

90033

USC Norris Comprehensive Cancer Center, Los Angeles

90602

PIH Health Hospital - Whittier, Whittier

90703

TOI Clincal Research, Cerritos

90720

Cancer and Blood Specialty Clinic, Los Alamitos

90813

City of Hope - Long Beach Elm, Long Beach

91326

University of California, Los Angeles (UCLA) - Porter Ranch, Porter Ranch

91355

Santa Clarita - UCLA, Valencia

91801

University of California, Los Angeles (UCLA) - Alhambra, Alhambra

92024

California Cancer Associates for Research & Excellence (San Diego Pacific Oncology and Hematology Associates) - Encinitas, Encinitas

92069

California Cancer Associates for Research & Excellence (San Diego Pacific Oncology and Hematology Associates) - San Marcos Cancer Center, San Marcos

92663

Keck Medicine of USC Norris Oncology/Hematology, Newport Beach

92868

University of California - Irvine Medical Center, Orange

93003

Ventura - UCLA, Ventura

93309

Comprehensive Blood And Cancer Center, Bakersfield

93401

Dignity Health- SLO Oncology and Hematology, San Luis Obispo

University of California, Los Angeles (UCLA) - San Luis Obispo, San Luis Obispo

93454

Mission Hope Cancer Center, Santa Maria

94117

St. Mary's Medical Center - San Francisco, San Francisco

95204

Dignity Health St. Joseph's Medical Center Stockton, Stockton

Stockton Hematology Oncology Medical Group (Stockton), Stockton

95340

Mercy Cancer Center, Merced

Mercy UC Davis Center Center, Merced

97213

Providence Portland Medical Center, Portland

97401

Willamette Valley Cancer Institute and Research Ctr, Eugene

98201

Providence Regional Cancer Partnership, Everett

99204

MultiCare Regional Cancer Center, Spokane

80120-4413

Rocky Mountain Cancer Centers (W Dry Creek Circle), Littleton

02111

Tufts Medical Center, Boston

79606-5208

Texas Oncology - West Texas (Antilley Rd), Abilene

0160

TIM - Tbilisi Institute of Medicine LLC, Tbilisi

0112

Israel-Georgia Medical Research Clinic Healthycore LLC, Tbilisi

Todua Clinic LLC, Tbilisi

0144

Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic LLC, Tbilisi

0177

Oncology Scientific Research Center LLC, Tbilisi

0186

Multiprofile Clinic Consilium Medulla LLC, Tbilisi

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Medpace, Inc.

INDUSTRY

collaborator

ICON plc

INDUSTRY

lead

Effector Therapeutics

INDUSTRY