60
Participants
Start Date
June 4, 2019
Primary Completion Date
February 4, 2022
Study Completion Date
February 4, 2022
cholecalciferol
Enrolled subjects will supplement with vitamin D3 at 4,000 IU daily for one year
Standard of Care Prostate Biopsy - collection of 13th core for RNA-seq
RNA-seq analysis will be used to (a) identify changes in transcriptional profiles and biological pathways in the prostate between African American and Caucasian men and (b) compare Allostatic Load results to determine stress response and (c) identify changes in the molecular signature in relation to vitamin D levels
Standard of Care Prostate Biopsies at baseline and after one year vitamin D3 supplementation
Pathology results of the prostate biopsies will be analyzed for changes in the (a) Gleason Score (b) the number of positive cores (0 to 12) and (c) the highest percentage of positive core involvement (0 to 100%).
Allostatic Load
"Diagnostic Test: Allostatic Load Measurements at baseline and after one year vitamin D3 supplementation Allostatic Load measurements to determine body stress compared at baseline and after one year of vitamin D3 supplementation. Also compared with RNA-seq results to determine stress response.~Other Names:~Bloodwork for HgbA1c, lipid profile, creatinine, albumin and vitamin D levels. Body measurements: Ht. Wt, BMI, waist and hip measurements for waist/hip ratio. Measurements of systolic and diastolic blood pressure and heart rate"
Ralph H. Johnson VA Medical Center, Charleston
Ralph H. Johnson VA Medical Center
FED
National Institute on Minority Health and Health Disparities (NIMHD)
NIH
Medical University of South Carolina
OTHER