A Study of Avutometinib (VS-6766) + Defactinib in Recurrent KRAS G12V, Other KRAS and BRAF Non-Small Cell Lung Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

December 31, 2020

Primary Completion Date

August 29, 2023

Study Completion Date

December 12, 2023

Conditions
Non Small Cell Lung CancerKRAS Activating Mutation
Interventions
DRUG

avutometinib (VS-6766)

Monotherapy

DRUG

avutometinib (VS-6766) and Defactinib

Combination therapy

Trial Locations (45)

10043

Azienda Ospedaliera Universitaria, Orbassano

11042

Northwell Health-Monter Cancer Center, Lake Success

13915

Hopital Nord Marseille, Marseille

15006

Complejo Hospitalario Universiario a Coruna Teresa, A Coruña

15232

Univ. of Pittsburgh Med Center, Pittsburgh

19111

Fox Chase Cancer Center, Philadelphia

20007

Georgetown University Medical Center, Washington D.C.

21044

Maryland Oncology Hematology P.A, Columbia

22031

Virginia Cancer Specialists, PC, Fairfax

28041

Hospital 12 de Octubre, Córdoba

29010

Universitario de Teatinos, Málaga

30322

Emory University School of Medicine, Atlanta

33611

Evangelisches Klinkum Bethel, Straße

33705

Florida Cancer Specialists, St. Petersburg

33908

Florida Cancer Specialists, Fort Myers

37134

Centro Ricerche Cliniche di Verona, Verona

37203

Tennessee Oncology, Nashville

41009

Hospital Universitario Virgen de la Macarena, Seville

43126

UOC di Oncologia Medica, Parma

43219

Zangmeister Cancer Center, Columbus

44805

Institute De Cancerologie De L'Ouest Site Paul Papin Oncologie Medicale, Saint-Herblain

47014

Irccs, Irts, Meldola

48202

Henry Ford Cancer Institute/Henry Ford Health System, Detroit

60611

Northwestern University, Chicago

60637

University of Chicago Medical Center-Duchossois Center for Advanced Medicine, Chicago

60714

Illinois Cancer Specialists, Niles

63110

Washington University School of Medicine, St Louis

69373

Centre Leon Berard, Lyon

70809

Hematology/Oncology Clinic, LLP, Baton Rouge

75014

Hopital Cochin, Paris

75246

Texas Oncology, Dallas

76051

Texas Oncology, Grapevine

76104

Texas Oncology Ft Worth Cancer Center, Fort Worth

77030

MD Anderson Cancer Center, Houston

80045

University of Colorado Hospital, Aurora

80124

Rocky Mountain Cancer Centers, Lone Tree

91010

City of Hope, Duarte

94800

Cancerologie Gustave Roussy - Cancer Medicine, Villejuif

97213

Northwest Cancer Specialists, P.C., Portland

02215

Dana Farber Cancer Institute, Boston

07601

Hackensack University Medical Center, Hackensack

037404

Chattanooga Oncology Hematology Assoc., Chattanooga

09116

Klinikum Chemnitz gGmbH, Chemnitz

04103

Universitatsklinkum Leipzig, Leipzig

Unknown

Hospital Clinic de Barcelona, Barcelona

All Listed Sponsors
lead

Verastem, Inc.

INDUSTRY

NCT04620330 - A Study of Avutometinib (VS-6766) + Defactinib in Recurrent KRAS G12V, Other KRAS and BRAF Non-Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter