Effect of Chewing a Calcium Supplement Before Fluoride Rinse on Salivary Fluoride

EARLY_PHASE1CompletedINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

February 1, 2021

Primary Completion Date

March 31, 2022

Study Completion Date

March 31, 2022

Conditions
Dental Caries
Interventions
DRUG

Inactive supplement

Chewable candy (negative control), chewed for 30 seconds.

DRUG

Tricalcium phosphate supplement

Chewable tricalcium phosphate supplement, chewed for 30 seconds.

DRUG

Calcium carbonate supplement

Chewable calcium carbonate supplement, chewed for 30 seconds.

DRUG

Calcium citrate supplement

Chewable calcium citrate supplement, chewed for 30 seconds.

DRUG

Inactive supplement and fluoride mouthwash

A chewable candy chewed for 30 seconds, immediately followed by a 1 minute rinse with an over the counter sodium fluoride mouthwash, at a concentration of 0.05% (226 parts per millim (ppm) of fluoride).

DRUG

Calcium carbonate supplement and fluoride mouthwash

A calcium carbonate supplement chewed for 30 seconds, immediately followed by a 1 minute rinse with an over the counter sodium fluoride mouthwash, at a concentration of 0.05% (226 parts per millim (ppm) of fluoride).

DRUG

Calcium citrate supplement and fluoride mouthwash

A calcium citrate supplement chewed for 30 seconds, immediately followed by a 1 minute rinse with an over the counter sodium fluoride mouthwash, at a concentration of 0.05% (226 parts per millim (ppm) of fluoride).

Trial Locations (1)

48109-1078

School of Dentistry, University of Michigan, Ann Arbor

All Listed Sponsors
lead

University of Michigan

OTHER

NCT04620252 - Effect of Chewing a Calcium Supplement Before Fluoride Rinse on Salivary Fluoride | Biotech Hunter | Biotech Hunter