A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

542

Participants

Timeline

Start Date

December 15, 2020

Primary Completion Date

September 30, 2025

Study Completion Date

September 30, 2025

Conditions
Non-small Cell Lung Cancer (NSCLC)
Interventions
DRUG

Tiragolumab

Tiragolumab at a fixed dose of 600 milligrams (mg), administered by intravenous (IV) infusion, every 3 weeks (Q3W) on Day 1 of each 21-day cycle.

DRUG

Atezolizumab

Atezolizumab at a fixed dose of 1200 mg, administered by IV infusion, Q3W on Day 1 of each 21-day cycle.

DRUG

Pemetrexed

Pemetrexed 500 milligrams per square meter (mg/m\^2), administered by IV infusion, Q3W on Day 1 of each 21-day cycle.

DRUG

Carboplatin

Carboplatin at dose of area under the concentration-time curve (AUC) of 5, administered by IV infusion, Q3W on Day 1 of each 21-day cycle for 4 cycles.

DRUG

Cisplatin

Cisplatin 75 mg/m\^2, administered by IV infusion, Q3W on Day 1 of each 21-day cycle for 4 cycles.

DRUG

Tiragolumab Matching Placebo

Matching placebo, administered by IV infusion, Q3W on Day 1 of each 21-day cycle.

DRUG

Pembrolizumab

Pembrolizumab at a fixed dose of 200 mg, administered by IV infusion, Q3W, on Day 1 of each 21-day cycle.

Trial Locations (128)

500

Changhua Christian Hospital, Chang-hua

1023

Auckland City Hospital, Cancer and Blood Research, Auckland

1200

Cliniques Universitaires St-Luc, Brussels

2100

Rigshospitalet, København Ø

3112

Tauranga Hospital, Clinical Trials Unit, Tauranga

3204

Waikato Hospital - Cancer and Blood Research Trials Unit, Hamilton

4000

Sjællands Universitetshospital, Roskilde, Roskilde

4442

Palmerston North Hospital, Palmerston North

5000

Odense Universitetshospital, Onkologisk Afdeling R, Odense C

5001

Kantonsspital Aarau, Aarau

5530

CHU UCL Mont-Godinne, Mont-godinne

7000

Kantonsspital Graubünden Medizin Onkologie, Chur

8091

UniversitätsSpital Zürich, Zurich

9100

Vitaz, Sint-Niklaas

9300

AZORG Campus Aalst-Moorselbaan, Aalst

10300

Vajira Hospital, Bangkok

10330

Chulalongkorn Hospital, Bangkok

10700

Faculty of Med. Siriraj Hosp., Bangkok

11217

Taipei Veterans General Hospital, Taipei

13915

Hopital Nord, Marseille

14165

Helios Klinikum Emil von Behring GmbH, Berlin

15006

Complejo Hospitalario Universitario A Coruña (CHUAC), A Coruña

16149

A.O. Villa Scassi, Genoa

16247

St. Vincent's Hospital, Gyeonggi-do

21280

Dicle University Faculty of Medicine, Diyarbakır

22030

Trakya University Medical Faculty, Edirne

22031

Inova Schar Cancer Institute, Fairfax

27003

Hospital Lucus Augusti, Lugo

28007

Hospital General Universitario Gregorio Marañon, Madrid

28046

Hospital Universitario La Paz, Madrid

30060

Northwest Georgia Oncology Centers PC - Marietta, Marietta

31100

CHU de Toulouse - Hôpital Larrey, Toulouse

32789

Advent Health Orlando, Winter Park

33076

Institut Bergonie, Bordeaux

33081

Centro Di Riferimento Oncologico, Aviano

33705

SCRI Florida Cancer Specialists North, St. Petersburg

33901

SCRI Florida Cancer Specialists South, Fort Myers

34000

Istanbul University Cerrahpasa Medical Faculty, Istanbul

34722

Medeniyet University Goztepe Training and Research Hospital., Kadiköy

35015

Chungnam National University Hospital, Daejeon

35016

Complejo Hospitalario Universitario Insular?Materno Infantil, Las Palmas de Gran Canaria

35032

Klinikum der Philipps-Universität Marburg, Marburg

35033

Hopital de Pontchaillou, Rennes

37203

Sarah Cannon Research Institute / Tennessee Oncology, Nashville

37403

Tennessee Oncology Chattanooga, Chattanooga

40447

China Medical University Hospital, Taichung

40503

Baptist Health Lexington, Lexington

41014

Hospital Univ. Nuestra Señora de Valme, Seville

41404

Kyungpook National University Chilgok Hospital, Daegu

46010

Hospital Clinico Universitario de Valencia, Valencia

46804

Fort Wayne Medical Oncology and Hematology, Inc, Fort Wayne

49267

Kosin University Gospel Hospital, Busan

50139

Azienda Ospedaliero-Universitaria Careggi, Florence

50200

Maharaj Nakorn Chiang Mai Hospital, Chiang Mai

51353

Samsung Changwon Hospital, Gyeongsangnam-do

55131

Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Medizinische Klinik, Pneumologie, Mainz

67091

CHU Strasbourg - Nouvel Hopital Civil, Strasbourg

76000

Cuidados oncologicos, Querétaro City

76137

St. Vincentius Kliniken Karlsruhe, Karlsruhe

78209

Oncologico Potosino, San Luis Potosí City

90095

UCLA, Los Angeles

90110

Songklanagarind Hospital, Songkhla

90505

Torrance Memorial Physician Network/Cancer Care, Torrance

90602

PIH Health Whittier Hospital, Whittier

100142

Beijing Cancer Hospital, Beijing

132013

Jilin Cancer Hospital, Changchun

213003

Changzhou First People's Hospital, Changzhou

230088

Anhui Provincial Hospital, Hefei

250013

Jinan Central Hospital, Jinan

261041

Weifang People's Hospital, Weifang

266042

Qingdao Central Hospital, Qingdao

337000

Pingxiang People Hospital, Pingxiang

410008

Xiangya Hospital Central South University, Changsha

430079

Hubei Cancer Hospital, Wuhan

450052

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

453000

The First Affiliated Hospital of Xinxiang Medical University, Xinxiang

610041

Sichuan Cancer Hospital, Chengdu

610047

West China Hospital - Sichuan University, Chengdu

710061

The First Affiliated Hospital of Xian Jiao Tong University, Xi'an

60336-550

Crio - Centro Regional Integrado de Oncologia, Fortaleza

30360-680

Oncocentro Belo Horizonte, Belo Horizonte

98700-000

Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijuí

90035-903

Hospital das Clinicas - UFRGS, Porto Alegre

91350-200

Hospital Nossa Senhora da Conceicao, Porto Alegre

14784-400

Hospital de Cancer de Barretos, Barretos

01246-000

Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo

T6G 1Z2

Cross Cancer Institute, Edmonton

L4M 6M2

Royal Victoria Regional Health Centre, Barrie

P6B 0A8

Sault Area Hospital, Sault Ste. Marie

067020

Affiliated Hospital of Chengde Medical University, Chengde

09116

Klinikum Chemnitz gGmbH, Chemnitz

Unknown

Hong Kong United Oncology Centre, Hong Kong

Queen Mary Hospital, Hong Kong

Tuen Mun Hospital, Hong Kong

Prince of Wales Hospital, Shatin

812-8582

Kyushu University Hospital, Fukuoka

830-0011

Kurume University Hospital, Fukuoka

734-8551

Hiroshima University Hospital, Hiroshima

665-0827

Takarazuka City Hospital, Hyōgo

602-8566

University Hospital Kyoto Prefectural University of Medicine, Kyoto

981-0914

Sendai Kousei Hospital, Miyagi

541-8567

Osaka International Cancer Institute, Osaka

573-1191

Kansai Medical University Hospital, Osaka

589-8511

Kindai University Hospital, Osaka

591-8555

NHO Kinki Chuo Chest Medical Center, Osaka

362-0806

Saitama Cancer Center, Saitama

135-8550

The Cancer Institute Hospital of JFCR, Tokyo

641-8510

Wakayama Medical University Hospital, Wakayama

03100

Health Pharma Professional Research, Mexico City

06700

ARKE Estudios Clínicos S.A. de C.V., Mexico City

90-338

Centrum Terapii Wspolczesnej J.M.Jasnorzewska Spolka Komandytowo-Akcyjna, ?ód?

10-357

Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie, Olsztyn

03080

Seoul National University Hospital, Seoul

03181

Kangbuk Samsung Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06591

Seoul St Mary's Hospital, Seoul

07198

Hospital Son Llatzer, Palma de Mallorca

08908

ICO L'Hospitalet, L'Hospitalet de Llobregat

08003

Hospital del Mar, Barcelona

08036

Hospital Clinic Barcelona, Barcelona

06490

Ankara Bilkent City Hospital, Ankara

06680

Liv Hospital Ankara, Ankara

HU16 5JQ

Castle Hill Hospital, Hull

EC1A 7BE

Barts & London School of Med, London

SE1 9RT

Guy'S Hospital, London

M2O 4BX

Christie Hospital Nhs Trust, Manchester

NG5 1PB

Nottingham City Hospital, Nottingham

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY