HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

277

Participants

Timeline

Start Date

February 2, 2021

Primary Completion Date

November 21, 2022

Study Completion Date

January 30, 2026

Conditions
Non-Small Cell Lung Cancer MetastaticNon-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor
Interventions
DRUG

Patritumab Deruxtecan (Fixed dose)

Patritumab deruxtecan will be dosed at 5.6 mg/kg as an intravenous (IV) infusion administered on Day 1 of each 21-day cycle.

DRUG

Patritumab Deruxtecan (Up-Titration)

Patritumab deruxtecan will be dosed as an intravenous (IV) infusion administered at Cycle 1, 3.2 mg/kg; Cycle 2, 4.8 mg/kg; Cycle 3 and subsequent cycles, 6.4 mg/kg administered on Day 1 of each 21-day cycle.

Trial Locations (123)

100

National Taiwan University Hospital NTUH, Taipei

333

Chang Gung Memorial Hospital - Linkou Branch, Taoyuan District

420

Chung Shan Medical University Hospital, Taichung

704

National Cheng Kung University Hospital, Tainan City

824

E-Da Hospital, Kaohsiung City

1030

Karl Landsteiner Institut für Lungenforschung und pneumologische Onkologie c/o Klinik Floridsdorf, Vienna

1303

MHAT Serdika, Sofia

2050

The Chris O'Brien Lifehouse, Camperdown

2148

Blacktown Hospital, Blacktown

2217

St George Public Hospital, Kogarah

3000

Peter MacCallum Cancer Centre, Melbourne

Universitaire Ziekenhuis Gasthuisberg, Leuven

4102

Princess Alexandra Hospital, Woolloongabba

4500

MHAT Uni Hospital OOD, Panagyurishte

6008

St John of God Subiaco Hospital, Subiaco

7002

Complex Oncological Center - Russe, Rousse

10029

Mount Sinai Hospital, New York

10043

Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano

10065

Memorial Sloan Kettering Cancer Center, New York

10408

National Cancer Center, Goyang-si

10449

MacKay Memorial Hospital, Taipei

10461

Montefiore Medical Center, The Bronx

13620

Seoul National University Bundang Hospital, Seongnam

20089

Humanitas Cancer Center, Rozzano

20133

Fondazione IRCCS Istituto Nazionale Tumori, Milan

21201

University of Maryland - Marlene and Stewart Greenebaum Cancer Center, Baltimore

22031

Virginia Cancer Specialist, PC, Fairfax

22903

University of Virginia Cancer Center - Emily Couric Clinical Cancer Center, Charlottesville

22927

LungenClinic Grosshansdorf, Großhansdorf

28033

MD Anderson Cancer Center, Madrid

28040

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28050

START Madrid - Hospital Universitario HM Sanchinarro, Madrid

28204

Levine Cancer Institute, Charlotte

28222

Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda

28644

Chungbuk National University Hospital, Cheongju-si

29010

Hospital Regional Universitario Carlos Haya, Málaga

29609

Hopital Morvan CHU de Brest, Brest

30338

Emory University, Dunwoody

31059

CHU Toulouse - Hopital Larrey, Toulouse

32308

Florida Cancer Specialists-Panhandle, Tallahassee

32804

AdventHealth Orlando, Orlando

33021

Memorial Healthcare System, Pembroke Pines

33401

Florida Cancer Specialists-East, West Palm Beach

33612

H. Lee Moffitt Cancer Center & Research Institute, Tampa

33770

Florida Cancer Specialist-North, St. Petersburg

33901

Florida Cancer Specialists - South, Fort Myers

35000

Hopital Pontchaillou, Rennes

37203

Sarah Cannon Research Institute, Nashville

37404

Sarah Cannon Research Institute at Tennessee Oncology - Chattanooga, Chattanooga

38043

Centre Hospitalier Universitaire de Grenoble, Grenoble

40705

Taichung Veterans General Hospital, Taichung

41009

Hospital Universitario Virgen Macarena, Seville

41404

Kyungpook National University Chilgok Hospital, Daegu

43126

Azienda Ospedaliero Universitaria di Parma, Parma

44000

University Hospital of Nantes - Thoracic Oncology, Nantes

44195

Cleveland Clinic - Main Campus, Cleveland

47014

IRCCS - Istituto Scientifico Romagnolo per lo Studio e La Cura Dei Tumori ISRT, Meldola

48202

Henry Ford Cancer Institute/Henry Ford Hospital, Detroit

50009

Hospital Clinico Universitario Lozano Bleza, Zaragoza

50931

Universitaet zu Koeln - Uniklinik Koeln, Cologne

50937

Universitaet zu Koeln - Uniklinik Koeln, Cologne

51109

Kliniken der Stadt Koeln gGmbH Lungenklinik Merheim, Cologne

Kliniken der Stadt Koeln gGmbH Lungenklinik Merheim, Cologne

60611

Northwestern University, Chicago

69008

Centre Leon Berard, Lyon

75248

Institut Curie, Paris

80045

University of Colorado Denver - Anschutz Medical Campus, Aurora

83301

Chang Gung Memorial Hospital CGMH - Kaohsiung Branch, Niaosong

85234

Banner MD Anderson Cancer Center, Gilbert

90033

USC Norris Comprehensive Cancer Center, Los Angeles

90048

Cedars Sinai, West Hollywood

90813

Pacific Shores Medical Group, Long Beach

91010

City of Hope, Duarte

92093

Moores Cancer Center at the UC San Diego Health, La Jolla

92868

University of California at Irvine, Orange

94805

Gustave Roussy, Villejuif

97213

Providence Portland Medical Center, Portland

98109

University of Washington/Seattle Cancer Care Alliance, Seattle

100036

Beijing Cancer Hospital, Beijing

110001

The First Hospital of China Medical University, Shenyang

119074

National University Cancer Institute National University Hospital, Singapore

130012

Jilin Cancer Hospital, Changchun

150081

Harbin Medical University - Tumor Hospital (The Third Affiliated Hospital), Harbin

169610

National Cancer Centre Singapore NCCS, Singapore

200032

Fudan University - Shanghai Cancer Center FUSCC, Shanghai

210002

General Hospital of Eastern Theater Command, Nanjing

258499

OncoCare Cancer Centre- Gleneagles Medical Centre, Singapore

310003

The First Affiliated Hospital of College of Medicine Zhejiang University, Hangzhou

430022

Union Hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan

450008

Henan Cancer Hospital, Zhengzhou

510080

Guangdong Academy of Medical Science (GAMS) - Guangdong Provincial Peoples Hospital, Guangzhou

610041

University of Electronic Science & Technology of China (UESTC) - Sichuan Cancer Hospital & Institute (Sichuan Provincial Tumor Hospital, Chengdu

02114

Massachusetts General Hospital (MGH) - Hematology/Oncology, Boston

02215

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston

Dana-Farber Cancer Institute, Boston

01307

University Cancer Center, Dresden

277-0882

National Cancer Center Hospital East, Kashiwa

104-0045

National Cancer Center Hospital, Tokyo

National Cancer Center Hospital, Chuo Ku

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

003-0804

National Hospital Organization Hokkaido Cancer Center, Sapporo

National Hospital Organization Hokkaido Cancer Center, Sapporo

673-8558

Hyogo Cancer Center, Akashi

277-8577

National Cancer Center Hospital East, Chiba

135-8550

The Cancer Institute Hospital of JFCR, Ariake

980-0873

Sendai Kousei Hospital, Sendai

573-1191

Kansai Medical University Hospital, Hirakata

589-8511

Kindai University Hospital, Ōsaka-sayama

411-8777

Shizuoka Cancer Center, Nagaizumi-chō

961-8566

Niigata Cancer Center Hospital, Chūōku

811-1347

National Hospital Organization Kyushu Cancer Center, Fukuoka

1066CX

Netherlands Cancer Institute, Amsterdam

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

06591

The Catholic University of Korea, Seoul St. Marys Hospital, Seoul

08916

Catalan Institute of Badalona Hospital Germans Trias i Pujol ICO, Badalona

08035

Hospital Universitario Vall d'Hebron, Barcelona

B9 5SS

University Hospital Birmingham NHS Trust, Birmingham

E20 1JQ

The Royal Marsden NHS Foundation Trust, London

NW12PG

University College London Hospitals, London

M20 4BX

The Christie Hospital, Manchester

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo Co., Ltd.

INDUSTRY

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Daiichi Sankyo

INDUSTRY