Cross-neutralization Capacity of Immune Serum From Different Dosage of Sabin Inactivated Poliovirus Vaccine Immunization

NACompletedINTERVENTIONAL
Enrollment

250

Participants

Timeline

Start Date

July 20, 2019

Primary Completion Date

December 10, 2019

Study Completion Date

January 10, 2020

Conditions
Poliomyelitis
Interventions
BIOLOGICAL

Three doses of low-dosage investigational sIPV, vaccinated within one-month interval between doses

Antigen content: 7.5, 22.5, and 22.5 D-antigen unite for type 1, 2, and 3 in 0.5 ml diluent per dose

BIOLOGICAL

Three doses of medium-dosage investigational sIPV, vaccinated within one-month interval between doses

Antigen content: 15, 45, and 45 D-antigen unite for type 1, 2, and 3 in 0.5 ml diluent per dose

BIOLOGICAL

Three doses of high-dosage investigational sIPV, vaccinated within one-month interval between doses

Antigen content: 22.5, 67.5, and 67.5 D-antigen unite for type 1, 2, and 3 in 0.5 ml diluent per dose

BIOLOGICAL

Three doses of control wIPV, vaccinated within one-month interval between doses

Antigen content: 40, 8, and 32 D-antigen unite for type 1, 2, and 3 in 0.5 ml diluent per dose

BIOLOGICAL

Three doses of control sIPV, vaccinated within one-month interval between doses

Antigen content: 30, 32, and 45 D-antigen unite for type 1, 2, and 3 in 0.5 ml diluent per dose

Trial Locations (1)

221300

Pizhou Center for Disease Control and Prevention, Pizhou

All Listed Sponsors
lead

Sinovac Biotech Co., Ltd

INDUSTRY

NCT04618783 - Cross-neutralization Capacity of Immune Serum From Different Dosage of Sabin Inactivated Poliovirus Vaccine Immunization | Biotech Hunter | Biotech Hunter