Pre-operative RadiothErapy for Soft Tissue SarcOmas

NAActive, not recruitingINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

June 5, 2020

Primary Completion Date

May 31, 2027

Study Completion Date

December 31, 2027

Conditions
Soft Tissue Sarcoma Adult
Interventions
RADIATION

Hypofractionation

"Shorter radiation therapy means that a higher dose will be given on a daily basis. The goal is to target microscopic disease and decrease the chances of local recurrence.~Organs at risk (OAR) will receive doses following the constraints from the Timmerman tables used for reference when using 5 or more fractions of EBRT.~Treatment will be delivered every 2nd day, for a maximum of 3 fractions per week. Daily pretreatment Image Guided Radiotherapy Images (IGRT) (Cone-Beam CT - CBCT) will be co-registered with the CT simulation dataset to adjust patient position before each treatment by matching the bone adjacent to the planned tumour volume (PTV). Treatment will be administered if there is \<3 mm in any dimension, or rotation is \<3 degrees. If the isocentre set-up exceeds 3 mm at any given treatment session, the treatment couch will be translated to restore its planned position."

Trial Locations (1)

H4A 3J1

McGill University Health Centre-Cedars Cancer Centre, Montreal

All Listed Sponsors
lead

McGill University Health Centre/Research Institute of the McGill University Health Centre

OTHER