A Trial to Compare the Efficacy and Safety of Once-weekly Lonapegsomatropin With Placebo and a Daily Somatropin Product in Adults With Growth Hormone Deficiency

PHASE3CompletedINTERVENTIONAL
Enrollment

264

Participants

Timeline

Start Date

December 3, 2020

Primary Completion Date

November 2, 2023

Study Completion Date

December 1, 2023

Conditions
Growth Hormone DeficiencyEndocrine System DiseasesHormone Deficiency
Interventions
DRUG

Lonapegsomatropin

Due to the different human growth hormone (hGH) dose requirements, depending on participant's age and concomitant use of oral estrogen, this trial has 3 dosing groups per arm, followed by gradual increasing dose titration to a target maintenance dose.

OTHER

Placebo

The placebo for lonapegsomatropin drug product contained the same excipients as lonapegsomatropin drug product but does not contain lonapegsomatropin itself. The placebo solution was administered by subcutaneous (SC) injection via syringe and needle. Due to the different hGH dose requirements, depending on participant's age and concomitant use of oral estrogen, this trial has 3 dosing groups and the placebo received the same dose volume as if they were randomized to once-weekly lonapegsomatropin.

DRUG

Somatropin

Somatropin solution is provided in a pre-filled pen intended for daily subcutaneous injection. Due to the different hGH dose requirements, depending on participant's age and concomitant use of oral estrogen, this trial has 3 dosing groups per arm, followed by gradual increasing dose titration to a target maintenance dose.

Trial Locations (113)

2065

Ascendis Pharma Investigational Site, Saint Leonards

2100

Ascendis Pharma Investigational Site, Copenhagen

2109

Ascendis Pharma Investigational Site, Sydney

2300

Ascendis Pharma Investigational Site, Leiden

3010

Ascendis Pharma Investigational Site, Alicante

3050

Ascendis Pharma Investigational Site, Parkville

3065

Ascendis Pharma Investigational Site, Fitzroy

3128

Ascendis Pharma Investigational Site, Box Hill

3491

Ascendis Pharma Investigational Site, Ľubochňa

4440

Ascendis Pharma Investigational Site, Palmerston North

6009

Ascendis Pharma Investigational Site, Perth

6021

Ascendis Pharma Investigational Site, Wellington

8035

Ascendis Pharma Investigational Site, Barcelona

8041

Ascendis Pharma Investigational Site, Barcelona

10017

Ascendis Pharma Investigational Site, New York

10021

Ascendis Pharma Investigational Site, New York

10450

Ascendis Pharma Investigational Site, George Town

10676

Ascendis Pharma Investigational Site, Athens

11000

Ascendis Pharma Investigational Site, Belgrade

11527

Ascendis Pharma Investigational Site, Athens

11868

Ascendis Pharma Investigational Site, Bucharest

13385

Ascendis Pharma Investigational Site, Marseille

15212

Ascendis Pharma Investigational Site, Pittsburgh

15706

Ascendis Pharma Investigational Site, Santiago de Compostela

16132

Ascendis Pharma Investigational Site, Genova

16150

Ascendis Pharma Investigational Site, Kota Bharu

20089

Ascendis Pharma Investigational Site, Rozzano

21010

Ascendis Pharma Investigational Site, Vinnytsia

28006

Ascendis Pharma Investigational Site, Madrid

28557

Ascendis Pharma Investigational Site, Morehead City

31048

Ascendis Pharma Investigational Site, Haifa

34000

Ascendis Pharma Investigational Site, Kragujevac

35100

Ascendis Pharma Investigational Site, Izmir

35205

Ascendis Pharma Investigational Site, Birmingham

38039

Ascendis Pharma Investigational Site, Kayseri

41001

Ascendis Pharma Investigational Site, İzmit

41013

Ascendis Pharma Investigational Site, Seville

44093

Ascendis Pharma Investigational Site, Nantes

46202

Ascendis Pharma Investigational Site, Indianapolis

48126

Ascendis Pharma Investigational Site, Dearborn

54636

Ascendis Pharma Investigational Site, Thessaloniki

55905

Ascendis Pharma Investigational Site, Rochester

60611

Ascendis Pharma Investigational Site, Chicago

61103

Ascendis Pharma Investigational Site, Kharkiv

62250

Ascendis Pharma Investigational Site, Putrajaya

63110

Ascendis Pharma Investigational Site, St Louis

69677

Ascendis Pharma Investigational Site, Lyon

75013

Ascendis Pharma Investigational Site, Paris

75390

Ascendis Pharma Investigational Site, Dallas

75400

Ascendis Pharma Investigational Site, Malacca

76008

Ascendis Pharma Investigational Site, Ivano-Frankivsk

78232

Ascendis Pharma Investigational Site, San Antonio

80336

Ascendis Pharma Investigational Site, München

82606

Ascendis Pharma Investigational Site, Bratislava

85048

Ascendis Pharma Investigational Site, Phoenix

89148

Ascendis Pharma Investigational Site, Las Vegas

89511

Ascendis Pharma Investigational Site, Reno

90048

Ascendis Pharma Investigational Site, Los Angeles

90095

Ascendis Pharma Investigational Site, Los Angeles

90509

Ascendis Pharma Investigational Site, Torrance

93720

Ascendis Pharma Investigational Site, Fresno

94304

Ascendis Pharma Investigational Site, Palo Alto

97239

Ascendis Pharma Investigational Site, Portland

98108

Ascendis Pharma Investigational Site, Seattle

300723

Ascendis Pharma Investigational Site, Timișoara

700106

Ascendis Pharma Investigational Site, Iași

4941480

Ascendis Pharma Investigational Site, Petah Tikva

6423906

Ascendis Pharma Investigational Site, Tel Aviv

8410100

Ascendis Pharma Investigational Site, Beersheba

02114

Ascendis Pharma Investigational Site, Boston

0075

Ascendis Pharma Investigational Site, Yerevan

V6Z 1Y6

Ascendis Pharma Investigational Site, Vancouver

B3H 1V7

Ascendis Pharma Investigational Site, Halifax

0144

Ascendis Pharma Investigational Site, Tbilisi

0159

Ascendis Pharma Investigational Site, Tbilisi

546 42

Ascendis Pharma Investigational Site, Thessaloniki

00161

Ascendis Pharma Investigational Site, Rome

00168

Ascendis Pharma Investigational Site, Rome

650-0047

Ascendis Pharma Investigational Site, Kobe

211-8533

Ascendis Pharma Investigational Site, Kawasaki

222-0036

Ascendis Pharma Investigational Site, Yokohama

236-004

Ascendis Pharma Investigational Site, Yokohama

Japan

Ascendis Pharma Investigational Site, Matsumoto

634-8522

Ascendis Pharma Investigational Site, Kashihara

920-0293

Ascendis Pharma Investigational Site, Ishikawa

565-0871

Ascendis Pharma Investigational Site, Suita

260-8677

Ascendis Pharma Investigational Site, Chiba

812-8582

Ascendis Pharma Investigational Site, Fukuoka

890-8520

Ascendis Pharma Investigational Site, Kagoshima

216-8511

Ascendis Pharma Investigational Site, Kawasaki

480-1195

Ascendis Pharma Investigational Site, Nagakute

700-8558

Ascendis Pharma Investigational Site, Okayama

550-0006

Ascendis Pharma Investigational Site, Osaka

108-8329

Ascendis Pharma Investigational Site, Tokyo

990-9585

Ascendis Pharma Investigational Site, Yamagata

31-501

Ascendis Pharma Investigational Site, Krakow

93-338

Ascendis Pharma Investigational Site, Lodz

60-355

Ascendis Pharma Investigational Site, Poznan

03-242

Ascendis Pharma Investigational Site, Warsaw

50-367

Ascendis Pharma Investigational Site, Wroclaw

03722

Ascendis Pharma Investigational Site, Seoul

05278

Ascendis Pharma Investigational Site, Seoul

06591

Ascendis Pharma Investigational Site, Seoul

443-721

Ascendis Pharma Investigational Site, Suwon

06560

Ascendis Pharma Investigational Site, Ankara

07070

Ascendis Pharma Investigational Site, Antalya

09010

Ascendis Pharma Investigational Site, Aydin

03115

Ascendis Pharma Investigational Site, Kyiv

04001

Ascendis Pharma Investigational Site, Kyiv

04114

Ascendis Pharma Investigational Site, Kyiv

CF14 4XW

Ascendis Pharma Investigational Site, Cardiff

CV2 2DX

Ascendis Pharma Investigational Site, Coventry

LS9 7TF

Ascendis Pharma Investigational Site, Leeds

All Listed Sponsors
lead

Ascendis Pharma Endocrinology Division A/S

INDUSTRY

NCT04615273 - A Trial to Compare the Efficacy and Safety of Once-weekly Lonapegsomatropin With Placebo and a Daily Somatropin Product in Adults With Growth Hormone Deficiency | Biotech Hunter | Biotech Hunter