170
Participants
Start Date
May 7, 2021
Primary Completion Date
December 31, 2030
Study Completion Date
December 31, 2031
LN-145
A tumor sample is resected from each patient and cultured ex vivo to expand the population of tumor infiltrating lymphocytes. After lymphodepleting chemotherapy including cyclophosphamide and fludarabine, patient is infused with autologous TIL (LN-145), followed by IL-2.
LN-145
A tumor sample is obtained by image-guided core biopsy from each patient and cultured ex vivo to expand the population of tumor infiltrating lymphocytes. After lymphodepleting chemotherapy including cyclophosphamide and fludarabine, patient is infused with autologous TIL (LN-145) followed by IL-2.
RECRUITING
Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne
RECRUITING
Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis, Amsterdam
RECRUITING
St. Vincent's Hospital, Darlinghurst
RECRUITING
Westmead Hospital, Westmead
RECRUITING
Severance Hospital, Yonsei University, Seoul
RECRUITING
Hollywood Private Hospital Ramsay, Nedlands
RECRUITING
Samsung Medical Center, Seoul
WITHDRAWN
University Hospital of Zurich/ Universitätsspital Zürich, Zurich
RECRUITING
New York University Langone Medical Center, New York
WITHDRAWN
Icahn School of Medicine at Mount Sinai, New York
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
WITHDRAWN
Roswell Park Cancer Institute, Buffalo
WITHDRAWN
University of Rochester Medical Center, Rochester
RECRUITING
Allegheny General Hospital, Natrona Heights
WITHDRAWN
Fox Chase Cancer Center, Philadelphia
WITHDRAWN
Christiana Care Health System, Newark
RECRUITING
University of Maryland, Baltimore
RECRUITING
Gachon Unversity Gil Medical Center, Incheon
RECRUITING
VCU Medical Center (Virginia Commonwealth University), Richmond
RECRUITING
Novant Health - Winston-Salem, Winston-Salem
RECRUITING
Atrium Health Wake Forest University Health Sciences, Winston-Salem
RECRUITING
University of North Carolina, Chapel Hill
WITHDRAWN
Novant Health - Charlotte, Charlotte
RECRUITING
Augusta University, Augusta
WITHDRAWN
University of Florida Health Cancer Center, Gainesville
WITHDRAWN
AdventHealth Cancer Institute, Orlando
RECRUITING
Sylvester Comprehensive Cancer Center, Miami
RECRUITING
H Lee Moffitt Cancer Center and Research Institute, Tampa
RECRUITING
University of Tennessee Medical Center, Knoxville
RECRUITING
Baptist Cancer Center, Memphis
RECRUITING
University of Louisville, Louisville
RECRUITING
Ohio State University Comprehensive Cancer Center, Columbus
RECRUITING
University of Cincinnati Medical Center, Cincinnati
RECRUITING
Karmanos Cancer Institute, Detroit
WITHDRAWN
Henry Ford Health System, Detroit
RECRUITING
Universitätsklinikum Bonn, Bonn
RECRUITING
University of Minnesota, Minneapolis
RECRUITING
Sanford Cancer Center, Sioux Falls
RECRUITING
Avera Medical Group Cancer Institute, Sioux Falls
RECRUITING
Sanford Roger Maris Cancer Center, Fargo
WITHDRAWN
Advocate Aurora Health, Park Ridge
RECRUITING
Rush University Medical Center, Chicago
RECRUITING
University of Illinois Hospital & Health Sciences System, Chicago
RECRUITING
Universitätsklinikum Mannheim, Mannheim
RECRUITING
University of Nebraska Medical Center, Omaha
WITHDRAWN
University of Oklahoma, Oklahoma City
WITHDRAWN
Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas
RECRUITING
Houston Methodist, Houston
WITHDRAWN
University of Southern California, Los Angeles
WITHDRAWN
City of Hope, Duarte
WITHDRAWN
UC San Diego Moores Cancer Center, La Jolla
RECRUITING
Oregon Health and Science University, Portland
RECRUITING
Seattle Cancer Care Alliance, Seattle
RECRUITING
National Cancer Centre Singapore, Singapore
WITHDRAWN
Dana Farber Cancer Institute, Boston
RECRUITING
MD Anderson Cooper, Camden
RECRUITING
Princess Margaret Cancer Centre, Toronto
RECRUITING
Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal
RECRUITING
Universitätsklinikum Carl Gustav Carus, MK I, Dresden
RECRUITING
Royal Marsden Hospital, Chelsea
RECRUITING
Sarah Cannon Research Institute, London
RECRUITING
University College London, London
RECRUITING
The Christie NHS Foundation Trust, Manchester
RECRUITING
Guy's Hospital, London
Lead Sponsor
Iovance Biotherapeutics, Inc.
INDUSTRY