Linearity and Non-linearity of Cerebral Autoregulation

RecruitingOBSERVATIONAL
Enrollment

580

Participants

Timeline

Start Date

October 11, 2020

Primary Completion Date

December 31, 2023

Study Completion Date

December 31, 2025

Conditions
Stroke, Acute
Interventions
DIAGNOSTIC_TEST

Assessment of CA

As part of our routine stroke work up, each patient receives an initial CT scan with CT perfusion to indicate thrombolysis therapy (intravenous, mechanical, or both, depending on the time since first stroke symptoms and perfusion-mismatch), an MRI within 2 days, extracranial and transcranial Duplex ultrasound, echocardiography, continuous Monitoring of BP, O2, body temperature, NIHSS and Glagow Coma Scale (GCS) every 6 hours. Assessing CA by continuous recording of blood pressure, cerebral blood flow velocity, end-tidal CO2. Analysis via Transfer function estimates

DIAGNOSTIC_TEST

Assesment of CA only

Assessing CA by continuous recording of blood pressure, cerebral blood flow velocity, end-tidal CO2. Analysis via Transfer function estimates

Trial Locations (1)

6000

RECRUITING

Kantonsspital Luzern, Lucerne

All Listed Sponsors
lead

Luzerner Kantonsspital

OTHER