Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma

PHASE1RecruitingINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

May 24, 2021

Primary Completion Date

May 31, 2026

Study Completion Date

May 31, 2026

Conditions
Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System
Interventions
PROCEDURE

Bone Marrow Aspiration and Biopsy

Undergo bone marrow aspirate and biopsy

PROCEDURE

Computed Tomography

Undergo CT and PET/CT

PROCEDURE

Echocardiography Test

Undergo ECHO

DRUG

Lenalidomide

Given PO

PROCEDURE

Lumbar Puncture

Undergo lumbar puncture

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Methotrexate

Given IV or PO

BIOLOGICAL

Nivolumab

Given IV

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

BIOLOGICAL

Rituximab

Given IV

PROCEDURE

Ultrasound Imaging

Undergo testicular ultrasound

Trial Locations (52)

10032

RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10065

SUSPENDED

NYP/Weill Cornell Medical Center, New York

11030

RECRUITING

North Shore University Hospital, Manhasset

11042

RECRUITING

Northwell Health/Center for Advanced Medicine, Lake Success

13210

ACTIVE_NOT_RECRUITING

State University of New York Upstate Medical University, Syracuse

26506

RECRUITING

West Virginia University Healthcare, Morgantown

27599

RECRUITING

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

29425

RECRUITING

Medical University of South Carolina, Charleston

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

43623

ACTIVE_NOT_RECRUITING

Toledo Clinic Cancer Centers-Toledo, Toledo

48162

ACTIVE_NOT_RECRUITING

Toledo Clinic Cancer Centers-Monroe, Monroe

49221

ACTIVE_NOT_RECRUITING

Hickman Cancer Center, Adrian

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50263

RECRUITING

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50309

RECRUITING

Iowa Methodist Medical Center, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

RECRUITING

Broadlawns Medical Center, Des Moines

RECRUITING

Mercy Medical Center - Des Moines, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50316

SUSPENDED

Iowa Lutheran Hospital, Des Moines

50325

RECRUITING

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

50501

SUSPENDED

UI Healthcare Mission Cancer and Blood - Fort Dodge, Fort Dodge

54449

RECRUITING

Marshfield Medical Center-Marshfield, Marshfield

54476

RECRUITING

Marshfield Medical Center - Weston, Weston

54482

RECRUITING

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

RECRUITING

Marshfield Medical Center - Minocqua, Minocqua

54601

RECRUITING

Gundersen Lutheran Medical Center, La Crosse

54701

RECRUITING

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

RECRUITING

Marshfield Medical Center-Rice Lake, Rice Lake

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

70805

RECRUITING

LSU Health Baton Rouge-North Clinic, Baton Rouge

70808

RECRUITING

Our Lady of the Lake Physician Group, Baton Rouge

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

84112

ACTIVE_NOT_RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

94143

RECRUITING

UCSF Medical Center-Parnassus, San Francisco

50266-7700

SUSPENDED

Methodist West Hospital, West Des Moines

04102

RECRUITING

MaineHealth Maine Medical Center - Portland, Portland

04074

RECRUITING

MaineHealth Maine Medical Center- Scarborough, Scarborough

04106

RECRUITING

MaineHealth Cancer Care and IV Therapy - South Portland, South Portland

07902

RECRUITING

Overlook Hospital, Summit

02903

RECRUITING

Rhode Island Hospital, Providence

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT04609046 - Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma | Biotech Hunter | Biotech Hunter