Dexmedetomidine Supplemented Analgesia in Patients at High-risk of Obstructive Sleep Apnea

PHASE4CompletedINTERVENTIONAL
Enrollment

152

Participants

Timeline

Start Date

January 29, 2021

Primary Completion Date

August 17, 2022

Study Completion Date

September 20, 2022

Conditions
Obstructive Sleep ApneaAnalgesiaDexmedetomidineHigh-flow Nasal CannulaSleep Quality
Interventions
DRUG

Dexmedetomidine

Patient-controlled analgesia is provided for at least 24 hours but no more than 48 hours. The pump is established with morphine (0.5 mg/ml) and dexmedetomidine (1.25 microgram/ml), in a total volume of 160 ml normal saline, and programmed to deliver 2-ml boluses at 6 to 8-minute lockout intervals with a background infusion rate of 1 ml/h.

DRUG

Placebo

Patient-controlled analgesia is provided for at least 24 hours but no more than 48 hours. The pump is established with morphine (0.5 mg/ml), in a total volume of 160 ml normal saline, and programmed to deliver 2-ml boluses at 6 to 8-minute lockout intervals with a background infusion rate of 1 ml/h.

Trial Locations (1)

100034

Dong-Xin Wang, Beijing

All Listed Sponsors
lead

Peking University First Hospital

OTHER

NCT04608331 - Dexmedetomidine Supplemented Analgesia in Patients at High-risk of Obstructive Sleep Apnea | Biotech Hunter | Biotech Hunter