831
Participants
Start Date
December 21, 2020
Primary Completion Date
December 8, 2025
Study Completion Date
December 28, 2027
Encorafenib
75 mg capsules
Cetuximab
Injection for intravenous use 100 mg/vial, 200 mg/vial, or 500 mg/vial
Oxaliplatin
Powder for solution for intravenous use 50 mg/vial, 100 mg/vial, or 200 mg/vial
Irinotecan
Solution for intravenous infusion 40 mg/vial, 100 mg/vial, or 300 mg/vial
Leucovorin
Injection 50 mg/vial, 100 mg/vial, 200 mg/vial, or 350 mg/vial
5-FU
Injection for intravenous use 250 mg/vial, 500 mg/vial, or 1000 mg/vial
Capecitabine
150 mg or 500 mg Tablet
Bevacizumab
Optional Injection for intravenous use 100 mg/vial or 400 mg/vial
National Taiwan University Hospital, Taipei
Taipei Veterans General Hospital, Taipei
Chang Gung Medical Foundation-Linkou Branch, Taoyuan District
China Medical University Hospital, Taichung
National Cheng-Kung University Hospital, Tainan City
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City
Auckland City Hospital, Auckland
Université Libre de Bruxelles - Hôpital Erasme, Brussels
Cliniques universitaires Saint-Luc, Brussels
Medical Center Nadezhda Clinical EOOD, Sofia
Acibadem City Clinic MHAT Tokuda, Sofia
Instituto Médico Especializado Alexander Fleming, Buenos Aires
University Multiprofile Hospital for Active Treatment Sofiamed, Sofia
ZNA Middelheim, Antwerp
Chris O'Brien Lifehouse, Camperdown
GenesisCare - North Shore, St Leonards
GenesisCare North Shore, St Leonards
Rigshospitalet, Copenhagen
Liverpool Hospital, Liverpool
Wits Health Consortium (Pty) Ltd, Johannesburg
GZA Hospitals Campus Sint Augustinus, Wilrijk
Herlev and Gentofte Hospital, Herlev
Peter MacCallum Cancer Centre, Melbourne
UZ Leuven, Leuven
Alfred Health, Melbourne
Austin Health, Heidelberg
Monash Health, Clayton
Centro Medico San Roque, San Miguel de Tucumán
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège
MHAT Central Onco Hospital OOD, Plovdiv
Complex Oncology Center - Plovdiv EOOD, Plovdiv
Royal Brisbane & Women's Hospital, Herston
Princess Alexandra Hospital, Woolloongabba
MHAT Uni Hospital OOD, Panagyurishte
Odense University Hospital, Odense C
The Queen Elizabeth Hospital, Adelaide
"MHAT Dr. Tota Venkova AD", Gabrovo
Cancercare Langenhoven Drive Oncology Centre, Port Elizabeth
Grand Hôpital de Charleroi, Charleroi
St. Olavs hospital, Trondheim
Vejle Hospital-Sygehus Lillebaelt, Vejle
Vejle Sygehus, Vejle
Cancercare Rondebosch Oncology, Rondebosch
AZ Groeninge Campus Kennedylaan, Kortrijk
Aalborg Universitetshospital, Syd, Aalborg
Memorial Sloan Kettering Cancer Center, New York
Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano
Fondazione del Piemonte per l'Oncologia - Istituto di Candiolo IRCCS, Candiolo
Memorial Sloan Kettering Cancer Center - Main Campus, New York
National Cancer Center, Goyang-si
Memorial Sloan Kettering Cancer Center - Westchester, Harrison
Onkologische Schwerpunktpraxis Kurfuerstendamm, Berlin
Radiologie Berlin, Charlottenburg
Taipei Medical University Hospital, Taipei
Memorial Sloan Kettering Cancer Center- Nassau, Uniondale
Memorial Sloan Kettering Cancer Center Commack, Commack
HELIOS Klinikum Berlin Buch GmbH, Berlin
Fakultni Thomayerova nemocnice, Prague
UPMC Hillman Cancer Center, Pittsburgh
Complejo Hospitalario Universitario Santiago de Compostela, Santiago de Compostela
Istituto Europeo di Oncologia IRCCS, Milan
ASST Grande Ospedale Metropolitano Niguarda, Milan
Facharztzentrum Eppendorf, Hamburg
Turku University Hospital, Turku
Gachon University Gil Medical Center, Incheon
ZytoService Deutschland GmbH, Standort-Hamburg-Jenfeld, Hamburg
Radiologie im Israelitischen Krankenhaus, Hamburg
Virginia Commonwealth University, Richmond
Fondazione Poliambulanza Istituto Ospedaliero, Brescia
Hospital General Universitario Gregorio Marañon, Madrid
Hospital Universitario Ramon Y Cajal, Madrid
Hospital Universitario 12 de octubre, Madrid
Satakunnan Keskussairaala, Pori
Medizinische Hochschule Hannover, Hanover
Mount Sinai Comprehensive Cancer Center, Miami Beach
Mount Sinai Medical Center, Miami Beach
Mount Sinai Comprehensive Cancer Center, Aventura, Aventura
BRCR Global, Plantation
BRCR Medical Center Inc., Plantation
Tampereen yliopistollinen sairaala, Tampere
IRCCS Istituto Oncologico Veneto (IOV), Padua
Henry-Joyce Cancer Center, Nashville
Vanderbilt-Ingram Cancer Center, Nashville
The West Clinic. PLLC. dba West Cancer Center, Germantown
Hospital Universitario Virgen Del Rocio, Seville
Kyungpook National University Hospital, Daegu
Kyungpook National University Chilgok Hospital, Daegu
Azienda USL - IRCCS di Reggio Emilia - Arcispedale Santa Maria Nuova, Reggio Emilia
The Ohio State University James Cancer Hospital and Solove Research Institute, Columbus
Stefanie Spielman Comprehensive Breast Cancer, Columbus
Martha Morehouse Medical Plaza, Columbus
The James Outpatient Care West Campus, Columbus
Cleveland Clinic Taussig Cancer Center Investigational Pharmacy, Cleveland
Cleveland Clinic, Cleveland
Hospital Clinico Universitario de Valencia, Valencia
Hospital General Universitario de Valencia, Valencia
"Municipal Non-profit Enterprise City Clinical Hospital #4 of Dnipro City Council", Dnipro
Dong-A University Hospital, Busan
Hospital Universitario Miguel Servet, Zaragoza
"Communal enterprise Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional Council", Kryvyi Rih
University of Wisconsin Clinical Science Center, Madison
Mayo Clinic Rochester, Rochester
UChicago Medicine at Ingalls - Flossmoor, Flossmoor
UChicago Medicine Ingalls Memorial, Harvey
University of Chicago Comprehensive Cancer Center at Silver Cross Hospital, New Lenox
The University of Chicago Medicine Center for Advanced Care Orland Park, Orland Park
UChicago Medicine at Ingalls - Tinley Park, Tinley Park
Institut für Klinisch Onkologische Forschung, Frankfurt am Main
UChicago Medicine - River East, Chicago
University of Chicago Medical Center, Chicago
Siteman Cancer Center - North County, Florissant
Barnes- Jewish Hospital, St Louis
Washington University School of Medicine, St Louis
Siteman Cancer Center - South County, St Louis
Siteman Cancer Center - West County, Creve Coeur
Siteman Cancer Center - St Peters, City of Saint Peters
Accelerium, S. de R.L. de C.V., Monterrey
Centro de Investigacion Clinica de Oaxaca, Oaxaca City
Oncology Hematology West PC dba Nebraska Cancer Specialists, Papillion
Oncology Hematology West PC dba Nebraska Cancer Specialists, Omaha
Oncology Hematology West PC dba Nebraska Cancer Specialists, Omaha
Oncology Hematology West PC dba Nebraska Cancer Specialists, Omaha
Ochsner Clinic Foundation, New Orleans
IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo
University of Oklahoma Health Sciences Center, OU Health Stephenson Cancer Center, Oklahoma City
Chi Mei Hospital, Liouying, Tainan City
Ivano-Frankivsk National Medical University, Ivano-Frankivsk
"MNPE Prykarpatski Clinical Oncological Center of Ivano-Frankivsk Regional Council", Ivano-Frankivsk
The University of Texas MD Anderson Cancer Center, Houston
"Azienda Ospedaliera Universitaria dell'Università Luigi Vanvitelli di Napoli", Napoli
Muenchen Klinik Neuperlach, Klinik fuer Haematologie und Onkologie, Munich
Mayo Clinic Hospital, Phoenix
Mayo Clinic in Arizona - Scottsdale, Scottsdale
Keck Hospital of USC, Los Angeles
LAC & USC Medical Center, Los Angeles
USC / Norris Comprehensive Cancer Center, Los Angeles
USC/Norris Comprehensive Cancer Center/Investigational Drug Services, Los Angeles
USC/Norris Comprehensive Cancer Center, Los Angeles
Norrlands universitetssjukhus, Umeå
Oulu University Hospital, Oulu
Keck Hospital of USC Pasadena, Pasadena
Providence Cancer Institute Franz Clinic, Portland
Providence Portland Medical Center, Portland
Providence Onc and Heme Care Clinic - Westside, Portland
Providence St Vincent Medical Center, Portland
Seattle Cancer Care Alliance, Seattle
University of Washington Medical Center, Seattle
Cancer Hospital Chinese Academy of Medical Science, Beijing
Peking University First Hospital, Beijing
Beijing Cancer hospital, Beijing
Beijing Hospital, Beijing
Shengjing Hospital Of China Medical University, Shenyang
Rajiv Gandhi Cancer Institute And Research Centre, New Delhi
FSAEI HE I.M Sechenov First MSMU MoH Russia (Sechenovskiy University),, Moscow
SHI YR Regional Clinical Oncology Hospital, Yaroslavl
"LLC Medicina Severnoy Stolitsy", Saint Petersburg
"LLC Severo-Zapadny Medical Center", Saint Petersburg
"Private Healthcare Institution Clinical Hospital RZD-Medicine of St. Petersburg", Saint Petersburg
"Private Medical Institution Euromedservice", Pushkin
"LLC EuroCityClinic", Saint Petersburg
"FSBI Russian Scientific Center For Radiology and Surgical Technologies n.a. Academician A.M. Granov", Saint Petersburg
Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai
Shanghai General Hospital, Shanghai
Fudan University Shanghai Cancer Center, Shanghai
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing
Kaluga Regional Clinical Oncology Center, Kaluga
Shandong province cancer hospital, Jinan
Tianjin Union Medical Center, Tianjin
R K Birla Cancer Center, SMS Hospital, Jaipur
Sawai Man Singh Medical College Hospital (SMS Hospital), Jaipur
The second Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou
Fujian Medical University Union Hospital, Fuzhou
Tata Memorial Hospital, Mumbai
Chongqing University Cancer Hospital, Chongqing
Bhakti Vedanta Hospital and Research Institute, Thāne
The Second Xiangya Hospital of Central South University, Changsha
The Third Xiangya Hospital of Central South University, Changsha
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan
GBUZ, Chelyabinsk
The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou
Affiliated Tumor Hospital of Guangxi Medical University, Nanning
Affiliated Tumor Hospital of Guangxi Medical University, Nanning
Sichuan Province Cancer Hospital, Chengdu
"BHI of Omsk Region Clinical Oncology Dispensary", Omsk
"BHI of Omsk Region Clinical Oncology Dispensary", Omsk
Yunnan Cancer Hospital(The Third Affiliated Hospital of Kunming Medical University), Kunming
Keio university hospital, Tokyo
Kanagawa cancer center, Yokohama
Osaka Prefectural Hospital Organization Osaka International Cancer Institute, Osaka
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos
Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto
Memorial Sloan Kettering Cancer Center - Basking Ridge, Basking Ridge
Summit Medical Group, Berkeley Heights
Summit Medical Group, Florham Park
Memorial Sloan Kettering Cancer Center- Monmouth, Middletown
Memorial Sloan Kettering Cancer Center- Bergen, Montvale
Clinica Universitaria Reina Fabiola, Córdoba
Hospital Privado Centro Médico de Córdoba, Córdoba
Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA, Rio de Janeiro
Hospital de Clinicas de Porto Alegre, Porto Alegre
Reichow - Centro de Ensino e Pesquisa, Blumenau
Clínica de Neoplasias Litoral, Itajaí
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - Faculdade de Medicina do ABC, Santo André
FUNDAÇÃO DO ABC - Faculdade de Medicina do ABC - Centro de Estudos e Pesquisas de Hematologia e Onco, Santo André
Arthur J.E. Child Comprehensive Cancer Centre, Calgary
Cross Cancer Institute, Edmonton
London Regional Cancer Program, London Health Sciences Centre, London
Sunnybrook Health Sciences Centre, Toronto
Jewish General Hospital, Montreal
Fakultní nemocnice Brno Bohunice, Brno
Fakultni nemocnice Hradec Kralove, Hradec Králové
Fakultni nemocnice Olomouc, Olomouc
Fakultni nemocnice Bulovka, Prague
Docrates Syöpäsairaala, Helsinki
Helsinki University Central Hospital, Helsinki
Universitätsklinikum Leipzig, Leipzig
Technische Universität Dresden, Medizinische Fakultät Carl Gustav Carus, Dresden
Universitätsklinikum Carl Gustav Carus Dresden, Dresden
Deenanath Mangeshkar Hospital & Research Centre, Pune
Sahyadri Speciality Hospital, Pune
"Azienda Ospedaliera Universitaria di Cagliari - Presidio Policlinico Universitario D.Casula", Monserrato (CA)
Chiba cancer center, Chiba
National Cancer Center Hospital East, Kashiwa
Hokkaido University Hospital, Sapporo
Kanazawa University Hospital, Kanazawa
St. Marianna University Hospital, Kawasaki
Aichi Cancer Center Hospital, Nagoya
Kindai University Hospital, Sayama
Osaka University Hospital, Suita
Osaka Medical and Pharmaceutical University Hospital, Takatsuki
Saitama Medical University International Medical Center, Hidaka
Saitama Prefectural Cancer Center, Ina-machi
Shizuoka Cancer Center, Nakatogari
National Cancer Center Hospital, Chuo-ku
The Cancer Institute Hospital of JFCR, Koto-ku
National Hospital Organization Kyushu Cancer Center, Fukuoka
National Hospital Organization - Osaka National Hospital - Institute For Clinical Research, Osaka
Catharina Ziekenhuis, Eindhoven
Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL), Amsterdam
Universitair Medisch Centrum Utrecht, Utrecht
Sørlandet Sykehus Kristiansand, Kristiansand
Oslo universitetssykehus, Radiumhospitalet, Oslo
Oslo Universitetssykehus Ullevål, Oslo
Przychodnia Lekarska KOMED, Konin
Szpital Specjalistyczny W Brzozowie, Podkarpacki Osrodek Onkologiczny Im.Ks.B.Markiewicza, Brzozów
Wojewodzki Szpital Specjalistyczny Nr 4 w Bytomiu Oddzial Onkologii, Bytom
COPERNICUS PL sp. z. o. o. Wojewodzkie Centrum Onkologii w Gdansku Ambulatoryjna, Gdansk
COPERNICUS Podmiot Leczniczy Sp. z o.o. Wojewodzkie Centrum Onkologii, Gdansk
Narodny Onkologicky Ustav, Bratislava
Vychodoslovensky onkologicky ustav, a.s., Košice
Korea University Anam Hospital, Seoul
Seoul National University Hospital, Seoul
Severance Hospital, Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
Hospital General Universitario de Elche, Elche
ICO L'Hospitalet (Hospital Duran i Reynals), L'Hospitalet de Llobregat
Hospital Universitario Vall d'Hebron, Barcelona
Hospital Clinic Barcelona, Barcelona
Karolinska Universitetssjukhuset Solna, Solna
Akademiska sjukhuset, Uppsala
Sahlgrenska Universitetssjukhuset, Gothenburg
Freeman Hospital, Newcastle upon Tyne
Royal Marsden NHS Foundation Trust, Sutton
Heartlands Hospital, Birmingham
Hammersmith Hospital, Imperial College Healthcare NHS Trust, London
Hammersmith Hospital, London
Churchill Hospital - Oncology, Oxford
Lead Sponsor
Collaborators (1)
Ono Pharmaceutical Co. Ltd
INDUSTRY
Merck KGaA, Darmstadt, Germany
INDUSTRY
Eli Lilly and Company
INDUSTRY
Pfizer
INDUSTRY