47
Participants
Start Date
October 6, 2020
Primary Completion Date
November 21, 2022
Study Completion Date
November 21, 2022
Derazantinib
Derazantinib was administered orally at a dose of 300 mg once daily as monotherapy in the Substudy 1 (Cohort 1.1).
Derazantinib-paclitaxel-ramucirumab combination
"Derazantinib was administered orally at a dose of 200 mg once daily in combination with paclitaxel and ramucirumab.~Paclitaxel was administered intravenously at a dose of 80 mg/m² on days 1, 8, and 15 of a 28-day cycle in combination with ramucirumab.~Ramucirumab was administered intravenously at a dose of 8 mg/kg every 2 weeks in combination with paclitaxel."
Derazantinib-paclitaxel-ramucirumab combination
"Derazantinib was administered orally at a dose of 300 mg once daily in combination with paclitaxel and ramucirumab.~Paclitaxel was administered intravenously at a dose of 80 mg/m² on days 1, 8, and 15 of a 28-day cycle in combination with ramucirumab.~Ramucirumab was administered intravenously at a dose of 8 mg/kg every 2 weeks in combination with paclitaxel."
Derazantinib
Derazantinib was administered orally at a dose of 200 mg twice daily as monotherapy in the Substudy 1 (Cohort 1.3).
Derazantinib
Derazantinib was administered orally at a dose of 300 mg once daily as monotherapy in the Substudy 1 (Cohort 1.2).
UZA, Edegem
Peter MacCallum Cancer Centre, Melbourne
UZ Leuven, Leuven
Monash Medical Centre Clayton, Clayton
The Alfred Hospital, Prahran
AZ Delta, Menen
Memorial Sloan Kettering Cancer Center, New York
National Cancer Center, Goyang-si
Seoul National University Bundang Hospital, Seongnam
Ajou University Hospital, Suwon
Istituto Clinico Humanitas, Rozzano
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
IEO Istituto Europeo di Oncologia, Milan
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda), Milan
Centre Georges François Leclerc, Dijon
CHU Besançon - Hôpital Jean Minjoz, Besançon
MD Anderson Cancer Centre, Madrid
Hospital Universitario Ramon y Cajal, Madrid
Centro Integral Oncologico Clara Campal, Madrid
Medizinische Hochschule Hannover, Hanover
Clinica Universidad de Navarra, Pamplona
AdventHealth Cancer Institute, Orlando
Istanbul University Cerrahpasa - Cerrahpasa Medical Faculty, Istanbul
Istanbul Medeniyet Uni Goztepe Training&Res Hosp, Istanbul
IOV - Istituto Oncologico Veneto IRCCS, Padua
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi, Bologna
Kocaeli Universitesi Tip Fakultesi, Kocaeli
A.O.U. Senese Policlinico Santa Maria alle Scotte, Siena
Uniklinik Mainz, Mainz
Chonnam National University Hwasun Hospital, Hwasun
Krankenhaus Nordwest GmbH, Frankfurt
Hôpital Saint-Louis, Paris
Hôpital Saint-Antoine, Paris
Institut Sainte Catherine, Avignon
Azienda Ospedaliero Universitaria Mater Domini, Catanzaro
Universitaetsklinikum Ulm, Ulm
Institut Gustave Roussy, Villejuif
"FSBSI Russian Oncological Scientific Center n.a. N.N. Blokhin", Moscow
"VitaMed LLC", Moscow
Pavlov First Saint Petersburg State Medical University, Saint Petersburg
"FSBI Clinical Research and Practical Center for specialized medical care (oncology)", Pesochnyy
"FBI Scientific Research Institute of Oncology n. a. N. N. Petrov", Saint Petersburg
"SAIH Republican Clinical Oncological Dispensary of the Ministry of Healthcare of Republic Tatarstan", Kazan'
SBIH Republican Clinical Oncological Dispensary of the MoH of Republic Bashkortostan, Ufa
Tomsk Research Instutite of Oncology, Tomsk
"BHI of Omsk region Clinical Oncology Dispensary", Omsk
Instituto Clinico Oncologico, Temuco
Centro de Estudios Clínicos SAGA, Santiago
CeCim Biocinetic, Santiago
Fundación Favaloro para la Docencia e Investigación Médica, Buenos Aires
Hospital de Gastroenterologia Dr. Carlos Bonorino Udaondo, Ciudad Autonoma Buenos Aires
Liga Norte-Rio-Grandense Contra o Câncer, Natal
Fundação Doutor Amaral Carvalho, Jaú
Instituto Nacional de Câncer José Alencar Gomes da Silva, Rio de Janeiro
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia, Santo André
Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto
Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden
Staedtisches Klinikum Dresden Standort Dresden-Friedrichstadt, Dresden
Centrum Terapii Wspolczesnej J.M. Jasnorzewska sp. komandytowo-akcyjna, Lodz
Examen sp. z o.o., Skórzewo
Centrum Zdrowia MDM, Warsaw
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Warsaw
Seoul National University Hospital, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul
Hospital del Mar, Barcelona
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clinic de Barcelona, Barcelona
ICO l'Hospitalet - Hospital Duran i Reynals, L'Hospitalet de Llobregat
Baskent University Adana Application and Research Center, Adana
Hacettepe University Medical Faculty, Ankara
Dr. Abdurrahman Yurtaslan Oncology Teaching and Research Hospital, Ankara
Ankara City Hospital, Ankara
Akdeniz University Medical Faculty, Antalya
Addenbrooke's Hospital, Cambridge
Ninewells Hospital, Dundee
Beatson West of Scotland Cancer Centre, Glasgow
University College London Hospitals, London
The Christie, Manchester
Royal Marsden Hospital- Sutton, Sutton
Lead Sponsor
Basilea Pharmaceutica
INDUSTRY