430
Participants
Start Date
April 9, 2021
Primary Completion Date
August 23, 2023
Study Completion Date
December 31, 2027
Pelabresib
"Double-blind treatment (pelabresib or matching placebo) will be administered daily for 14 consecutive days followed by a 7-day break, which is considered 1 cycle of treatment (1 cycle = 21 days).~Pelabresib is a small molecule inhibitor of BET proteins with a novel mechanism of action and potential for disease-modifying effects in MF."
Ruxolitinib
Ruxolitinib is a JAK inhibitor and a current, approved treatment option for MF.
Placebo
Placebo tablets are designed to match pelabresib tablets. Each placebo tablet contains no active pharmaceutical ingredient and is visibly identical to experimental drug in size, shape, and packaging. Placebo dosing follows the same dosing conventions as pelabresib.
Amsterdam UMC, Amsterdam
Cliniques universitaires Saint-Luc, Brussels
Monash Health, Clayton
Peninsula Private Hospital Clinical Trials Unit, Frankston
Domaine Universitaire du Sart Tilman, Liège
Krankenhaus der Elisabethinen Linz, Linz
Kepler University Hospital, Linz
Icon Cancer Centre, Brisbane
Royal Adelaide Hospital, Adelaide
University Hospital Salzburg, Salzburg
One Clinical Research PTY LTD, Nedlands
Hôpital de Jolimont, La Louvière
: Pecs University, 1st Department of Medicine, Pécs
Erciyes University Faculty of Medicine Hospital, Kayseri
ICO Badalona - Hospital Universitari Germans Trias i Pujol, Badalona
Hospital San Pedro de Alcantara, Cáceres
Icahn School of Medicine at Mount Sinai, New York
Memorial Sloan Kettering Cancer Center, New York
Weill Cornell Medical College- New York Presbyterian Hospital, New York
Hospital Ordine Mauriziano of Turin, Turin
Chulabhorn Hospital, Bangkok
King Chulalongkorn Memorial Hospital, Bangkok
Rajavithi Hospital, Bangkok
Hospital Pulau Pinang, George Town
University Hospital Hamburg-Eppendorf, Hamburg
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo
Regional Hospital Spedali Civili di Brescia, Brescia
University General Hospital of Patras, Rio
University Hospital Maggiore della Carità, Novara
Quirónsalud Madrid University Hospital, Madrid
Morales Meseguer General University Hospital, Murcia
Gard Cancer Institute, Nîmes
Mayo Clinic, Jacksonville
Hospital Universitario Central de Asturias, Oviedo
Moffitt Cancer Center, Tampa
Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria
Chu Pontchaillou - Service Hematologie, Rennes
University Hospital of Padova, Padua
Hospital Universitario de Salamanc, Salamanca
Hôpital Bretonneau, Tours
Srinagarind hospital,Khon Kaen University, Khon Kaen
A.O.U. Policlinico S. Orsola-Malpighi, Bologna
Norton Cancer Institute, St. Matthews Campus, Louisville
Kyungpook National University Hospital, Daegu
Institut de Cancérologie Lucien Neuwirth, Saint-Priest-en-Jarez
Cleveland Clinic Taussig Cancer Center, Cleveland
University Hospital of Toledo, Toledo
Hospital Clínico Universitario de Valencia, Valencia
Franciscan Health/Indiana blood and Marrow Transplantation, Indianapolis
Sunway Medical Centre, Petaling Jaya
Inje University Haeundae Paik Hospital, Busan
University of Michigan Medical Center, Ann Arbor
Rabin Medical Center - Beilinson Campus,, Petah Tikva
Pusan National University Hospital, Busan
Chru Brabois, Vandœuvre-lès-Nancy
Jeonbuk National University Hospital, Jeonju
Decatur Memorial Hospital Cancer Care Center of Decatur/Cancer Care Specialists of IL, Decatur
Washington University, St Louis
:Hospital Ampang, Ampang
Centre Hospitalier Lyon Sud Secteur 1G, Pierre-Bénite
Centre Hospitalier, Le Mans
MD Anderson Cancer Center, Houston
University of Texas Health Science Center - San Antonio, San Antonio
Amiens South Hospital univerisy - Hopital Sud, Amiens
Hospital Sultanah Aminah, Johor Bahru
Soroka Medical Center, Beersheba
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers, Chandler
Hämatologisch-Onkologische Praxis Augsburg, Augsburg
Hospital Queen Elizabeth, Kota Kinabalu
Universitätsklinikum Ulm, Ulm
USC/Norris Comprehensive Cancer Center, Los Angeles
UCLA Medical Center, Los Angeles
Songklanagarind Hospital, Songkhla
University Hospital 'Paolo Giaccone' Polyclinic, Palermo
UC San Diego Moores Cancer Center, La Jolla
Center for Blood Disorders and Cellular Therapy, Swedish Cancer Institute, Seattle
Shaarei Zedek, Nahariya
Rambam Health Corporation, Haifa
Lady Davis Carmel Medical Center, Haifa
Tel Aviv Sourasky Medical Center, Tel Aviv
Hadassah University Hospital-Ein Kerem, Jerusalem
Shamir Medical Center, Be’er Ya‘aqov
University of Alabama at Birmingham, Birmingham
Yale University School of Medicine, New Haven
USC Clinical Trials Centre Sunshine Coast Haematology and Oncology Clinic, Buderim
LKH - Universitätsklinikum Graz; Abteilung für Hämatologie, Graz
ZNA, Antwerp
UZ Leuven, Leuven
Laiko General Hospital, Athens
Princess Margaret Hospital, Hong Kong
Prince of Wales Hospital, Hong Kong
Szabolcs Szatmár Bereg Megyei Kórházak és Egyetemi Oktatókórház; Jósa András Oktatókórház, Hematológia, Nyíregyháza
Wolfson Medical Center, Holon
Azienda Ospedaliera Universitaria Arcispedale Sant'Anna, Ferrara
Azienda Ospedaliera Universitaria Careggi, Florence
"IRCCS Istituto Romagnolo per lo studio dei tumori Dino Amadori", Meldola
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan
Azienda Ospedaliera San Gerardo di Monza, Monza
AOU S.Luigi Gonzaga, Orbassano
Ospedale Sant'Eugenio, Rome
Ospedale di Circolo e Fondazione Macchi - ASST Sette Laghi, Varese
Pratia Onkologia Katowice, Katowice
Gyeongsang National University Hospital, Jinju
Inje University Busan Paik Hospital, Busan
Daegu Catholic University Medical Center, Daegu
The Catholic University Of Korea St. Vincent Hospital, Gyeonggi-do
Gachon University Gil Medical Center, Incheon
Korea University Anam Hospital, Seoul
Seoul National University Hospital, Seoul
The Catholic University of Korea, Seoul
The Catholic University of South Korea Seoul St. Mary's Hospital, Seoul
Ulsan University Hospital, Ulsan
Hospital Clinic de Barcelona, Barcelona
Vall d'Hebron Institute of Oncology, Barcelona
Hospital Virgen Macarena, Seville
Chang Gung Memorial Hospital Chiayi, Chiayi City
China Medical University Hospital, Chiayi City
Taichung Veterans General Hospital, Taichung
National Taiwan University Hospital, Taipei
Ankara University Faculty of Medicine Cebeci Research and Application Hospital, Ankara
Dr. Abdurrahman Yurtaslan Oncology Health Application and Research Center, Ankara
Antalya Medstar Hospital, Antalya
Edirne Trakya University Faculty of Medicine Hospital, Edirne
Gaziantep University Sahinbey Research and Application Center Hospital, Gaziantep
Izmir Ege University Faculty of Medicine Hospital, Izmir
Kocaeli University Application, Kocaeli
Mersin University, Mersin
Samsun 19 Mayıs University Health Application Research Hospital, Samsun
University College London Hospitals, London
Oxford University Hospitals NHS Foundation Trust, Department of Haematology, Cancer and Haematology Centre, Churchill Hospital, Oxford
Tom Baker Cancer Centre, Calgary
University of Alberta Hospital, Edmonton
London Health Sciences Center - Victoria Hospital, London
Princess Margaret Cancer Center, Toronto
Jewish General Hospital, Montreal
Fakultni nemocnice Hradec Kralove, Hradec Králové
University Hospital Olomouc, Olomouc
Hôpital l'Archet 1, Nice
Universitätsklinikum Halle (Saale), Krukenberg-Krebszentrum Halle (KKH), Halle
Universitätsklinikum Jena, Klinik für Innere Medizin II, Jena
UGH of Ioannina, Ioannina
Hospital Sultanah Bahiyah, Alor Star
Maastricht University Medical Center, Maastricht
Wojewódzki Szpital Specjalistyczny w Bialej Podlaskiej, Biała Podlaska
Uniwersyteckie Centrum Kliniczne, Gdansk
Centrum Medyczne Pratia, Skorzewo
Nasz Lekarz Przychodnie Medyczne, Torun
Severance Hospital, Yonsei University Health System, Seoul
Samsung Medical Center, Seoul
Western General Hospital, Edinburgh
University Hospital of Wales, Cardiff
Pilgrim Hospital, Boston
Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge
The Clatterbridge Cancer Centre, Liverpool
Guy's & St Thomas NHS Foundation Trust, London
Imperial College Healthcare NHS Trust, Hammersmith Hospital, London
Lead Sponsor
Constellation Pharmaceuticals
INDUSTRY