ABemaciclib, ET ± paclItaxel in aGgressive HR+/HER2- MBC trIaL

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

162

Participants

Timeline

Start Date

June 2, 2021

Primary Completion Date

June 30, 2024

Study Completion Date

September 12, 2025

Conditions
Breast Cancer Metastatic
Interventions
DRUG

Abemaciclib

Patients will receive abemaciclib 150 mg orally twice daily (BID) (300 mg daily, administered as six 50 mg tablets) during each 28 day cycle combined with either letrozole or fulvestrant.

DRUG

Paclitaxel

Paclitaxel 90 mg/m² infused over 1 hour on Days 1, 8, and 15 of the 28 day cycle, with at least a 6-day time span between separated doses.

DRUG

Letrozole

Patients will receive 2.5 mg letrozole, orally administered and taken daily during each 28-day cycle combined with abemaciclib.

DRUG

Fulvestrant

Patients will receive 500 mg fulvestrant, by intramuscular \[IM\] administration on Days 1 and 15 (±3 days) of the first treatment cycle and Day 1 of each cycle thereafter combined with abemaciclib.

Trial Locations (31)

10126

Azienda Ospedaliero-Universitaria Cittá de la Salute e della Scienza, Torino

12002

Consorcio Hospitalario Provincial de Castellon, Castellon

14004

Hospital Universitario Reina Sofia, Córdoba

15009

Centro Oncoloxico de Galicia, A Coruña

17007

Institut Catala D'Oncologia Girona - Hospital Josep Trueta, Girona

18016

Hospital Universitario San Cecilio, Granada

20141

Instituto Europeo di Oncologia, Milan

20900

Ospedale San Gerardo, Monza

24073

Complejo Asistencial Universitario De León, León

25198

Hospital Universitario Arnau de Vilanova, Lleida

28006

Hospital Ruber Juan Bravo, Madrid

28007

Hospital Beata María Ana, Madrid

28034

Hospital Universitario Ramón y Cajal, Madrid

28040

Hospital Universitario Clinico San Carlos, Madrid

28046

Hospital Universitario La Paz, Madrid

29121

Ospedale Guglielmo da Saliceto, Piacenza

31008

Complejo Hospitalario de Navarra, Pamplona

41013

Hospital Quirónsalud Sagrado Corazón, Seville

43204

Hospital Universitari de Sant Joan de Reus, Reus

46010

Hospital Clinico Universitario de Valencia, Valencia

46014

Consorcio Hospital General Universitario de Valencia, Valencia

46015

Hospital Arnau de Vilanova, Valencia

48013

Hospital Universitario Basurto, Bilbao

50009

Hospital Universitario Miguel Servet, Zaragoza

460137

Hospital Quironsalud Valencia, Valencia

2720-276

Hospital Fernando da Fonseca, Amadora

1600-190

Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Lisbon

Unknown

Hospital Universitario Virgen del Rocio, Seville

Hospital Quiron Salud Dexeus, Barcelona

08243

Fundación Althaia Manresa, Manresa

03010

Hospital General Universitario de Alicante, Alicante

All Listed Sponsors
collaborator

Eli Lilly and Company

INDUSTRY

lead

MedSIR

OTHER