NCT04595877View on ClinicalTrials.gov

Double-blind, Randomized Controlled Study to Assess the Analgesic Effect of 2 g of Magnesium Dipyrone (Metamizol) and Changes in Plasma Beta-endorphin Immunoreactivity Values in Patients Undergoing Elective Inguinal Herniorrhaphy Under Epidural Anesthesia.

PHASE4CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

January 31, 2006

Primary Completion Date

May 31, 2006

Study Completion Date

May 31, 2006

Conditions
PainBeta-endorphinDipyroneHernia Surgery
Interventions
DRUG

Dipyrone administration

Dipyrone 2 g (Nolotil®, Europharma, Madrid, Spain); one ampoule in 50 mL of 0.9% saline solution as an intravenous infusion over 10 min.

BEHAVIORAL

Pain assessment

"Pain will be evaluated by the patient according to a 100-mm visual analogue scale (VAS) (from point 0 no pain to point 10 unbearable pain)."

BIOLOGICAL

beta-endorphin immunoreactivity

Plasma beta-EPIr levels will be measured by an immunoradiometric assay (Allegro Beta-endorphin, Nichols Institute Diagnostics, SAN JUAN DE CAPISTRANO, CA) (normal values 29-40 pg/mL). It will be obtained by venous blood samples (5 mL) at the same time points at pain will be measured.

OTHER

Placebo administration

Placebo in 50 mL of 0.9% saline solution as an intravenous infusion over 10 min.

Trial Locations (1)

28805

Nursing and Physiotherapy Department, Madrid

All Listed Sponsors
lead

Antonio Martín Duce

OTHER

NCT04595877 - Double-blind, Randomized Controlled Study to Assess the Analgesic Effect of 2 g of Magnesium Dipyrone (Metamizol) and Changes in Plasma Beta-endorphin Immunoreactivity Values in Patients Undergoing Elective Inguinal Herniorrhaphy Under Epidural Anesthesia. | Biotech Hunter | Biotech Hunter