A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis Bronchiectasis

PHASE3CompletedINTERVENTIONAL
Enrollment

1,767

Participants

Timeline

Start Date

December 1, 2020

Primary Completion Date

October 28, 2024

Study Completion Date

October 28, 2024

Conditions
Non-Cystic Fibrosis Bronchiectasis
Interventions
DRUG

Brensocatib 10 mg

Oral tablet.

DRUG

Brensocatib 25 mg

Oral tablet.

DRUG

Placebo

Brensocatib-matching oral tablet.

Trial Locations (373)

15

IRL003, Dublin

833

TWN001, Kaohsiung City

1051

NZL003, Auckland

NZL008, Auckland

1233

BGR010, Sofia

1336

BGR011, Sofia

1510

BGR009, Sofia

1640

NZL006, Otahuhu

1680

BGR002, Sofia

2100

DNK008, Copenhagen O

2145

AUS007, Westmead

2217

AUS013, Kogarah

2305

AUS008, New Lambton Heights

2700

BGR005, Blagoevgrad

2800

BEL003, Mechelen

HUN005, Tatabánya

2900

DNK004, Hellerup

3000

ARG019, Santa Fe

BEL001, Leuven

BGR016, Vratsa

3110

NZL007, Tauranga

3128

AUS002, Box Hill

3168

AUS014, Clayton

3204

NZL002, Hamilton

3320

BGR014, Kozloduy

3400

BGR007, Montana

3700

BGR013, Vidin

4000

BEL007, Liège

DNK002, Roskilde

4021

AUT002, Linz

4023

BGR004, Plovdiv

4032

AUS001, Chermside

4101

AUS006, South Brisbane

AUS019, South Brisbane

4120

AUS010, Greenslopes

4122

NZL009, Hastings

4400

BGR018, Pazardzhik

4870

AUS012, Cairns North

5000

AUS011, Adelaide

BGR012, Veliko Tarnovo

DNK005, Odense C

5006

AUS022, North Adelaide

5011

AUS009, Woodville South

5032

NZL011, Paraparaumu

5042

AUS017, Bedford Park

5300

BGR006, Gabrovo

5500

BGR015, Lovech

5800

ARG023, Río Cuarto

BGR019, Pleven

6002

FRA009, Nice

6009

AUS005, Nedlands

6010

TUR010, Ankara

6021

NZL010, Wellington

6150

AUS018, Murdoch

6163

AUS015, Spearwood

6340

TUR011, Ankara

7002

BGR008, Rousse

7100

DNK006, Vejle

8000

ARG027, Bahía Blanca

8011

NZL005, Christchurch

8036

ESP016, Barcelona

8800

BEL004, Roeselare

BGR017, Sliven

9000

BEL002, Ghent

BEL009, Ghent

DNK003, Aalborg

9001

NZL001, Dunedin

9100

BEL008, Sint-Niklaas

10002

TWN007, Taipei

10717

DEU002, Berlin

10961

DEU019, Berlin

11000

SRB001, Belgrade

SRB003, Belgrade

THA002, Muang

11217

TWN004, Taipei

11490

TWN006, Taipei

13125

DEU006, Berlin

13353

DEU011, Berlin

13620

KOR007, Seongnam-si

14467

DEU027, Potsdam

14584

KOR008, Bucheon-si

15001

PER001, Lima

15036

PER003, Lima

15084

PER002, Lima

15131

PER005, Chancay

15355

KOR015, Ansan-si

15706

ESP009, Santiago de Compostela

15801

USA038, DuBois

16150

MYS003, Kota Bharu

17007

ESP001, Girona

17110

TUR003, Çanakkale

18000

SRB007, Niš

19104

USA046, Philadelphia

20001

PER006, Piura

20007

USA001, Washington D.C.

20089

ITA011, Rozzano

20122

ITA006, Milan

ITA012, Milan

20157

ITA003, Milan

21018

UKR010, Vinnytsia

21431

KOR004, Incheon

21502

DEU020, Geesthacht

22060

TWN005, New Taipei City

23188

USA034, Williamsburg

25000

SRB014, Sombor

25100

MYS004, Kuantan

26120

THA004, Nakhonnayok

27100

ITA007, Pavia

27103

USA026, Winston-Salem

28007

ESP007, Madrid

28054

USA033, Gastonia

28223

ESP015, Pozuelo de Alarcón

29425

USA005, Charleston

29732

USA036, Rock Hill

30342

USA012, Atlanta

30625

DEU031, Hanover

DEU015, Hanover

30912

USA053, Augusta

31000

SRB010, Užice

31008

ESP011, Pamplona

31400

FRA006, Toulouse

32825

USA052, Orlando

33011

ESP008, Oviedo

33014

USA019, Miami Lakes

33079

TUR001, Mersin

33126

USA037, Miami

33324

USA103, Plantation

33606

USA120, Tampa

33704

USA089, St. Petersburg

33707

USA074, St. Petersburg

33765

USA015, Clearwater

34080

MEX006, Durango

34295

FRA005, Montpellier

34362

ISR008, Haifa

34746

USA039, Kissimmee

35037

DEU005, Marburg

35100

TUR008, Izmir

35110

TUR004, Izmir

36010

UKR005, Poltava

37067

USA041, Franklin

39008

ESP012, Santander

40002

THA003, Khon Kaen

40138

ITA010, Bologna

41380

TUR009, Kocaeli

42075

TUR005, Konya

42100

ITA002, Reggio Emilia

44093

FRA003, Nantes

44124

ITA008, Ferrara

44160

MEX007, Guadalajara

MEX008, Guadalajara

44195

USA093, Cleveland

44220

MEX005, Guadalajara

44281

ISR009, Kefar Sava

44700

MEX004, Guadalajara

45239

DEU013, Essen

45267

USA067, Cincinnati

48149

DEU029, Münster

49100

ISR011, Petah Tikva

49102

UKR012, Dnipro

50590

MYS005, Kuala Lumpur

50603

MYS001, Kuala Lumpur

52242

USA063, Iowa City

52621

ISR007, Ramat Gan

53100

ITA004, Siena

55128

DEU023, Mainz

55270

TUR006, Atakum

55905

USA010, Rochester

57010

GRC006, Thessaloniki

60153

USA061, Maywood

60389

DEU021, Frankfurt

60590

DEU008, Frankfurt am Main

61124

UKR001, Kharkiv

63017

USA006, Chesterfield

63110

USA059, St Louis

64460

MEX003, Monterrey

64718

MEX001, Monterrey

65025

UKR003, Odesa

66160

USA031, Kansas City

67091

FRA002, Strasbourg

68000

MEX002, Oaxaca City

68510

USA110, Lincoln

69126

DEU009, Heidelberg

70112

USA020, New Orleans

USA051, New Orleans

70300

ISR004, Ẕerifin

71110

GRC007, Heraklion

72032

USA080, Conway

72205

USA044, Little Rock

73003

UKR007, Kherson

75014

FRA010, Paris

75708

USA002, Tyler

76018

UKR009, Ivano-Frankivsk

76100

ISR003, Rehovot

78258

USA011, San Antonio

78278

ISR001, Ashkelon

80054

FRA004, Amiens

80336

DEU025, München

80756

TWN003, Kaohsiung City

82544

TWN002, Kaohsiung City

84101

ISR010, Beersheba

90048

USA055, Los Angeles

90127

ITA001, Palermo

91031

ISR006, Jerusalem

91120

ISR002, Jerusalem

92120

USA035, San Diego

92262

USA022, Palm Springs

92663

USA029, Newport Beach

93003

USA027, Ventura

93702

USA104, Fresno

94010

FRA011, Créteil

97239

USA023, Portland

110131

COL002, Bogota DC

111211

COL001, Bogotá

250252

COL006, Zipaquirá

681004

COL005, Floridablanca

760026

COL003, Santiago de Cali

1628655

JPN032, Shinjuku-ku

2260000

CHL004, Quillota

3440000

CHL005, Curicó

3481349

CHL010, Talca

5110683

CHL007, Valdivia

7500000

CHL001, Providencia

CHL002, Providencia

7500587

CHL008, Providencia

8408571

JPN030, Fukuoka

35233-1711

USA013, Birmingham

91324-3138

USA102, Northridge

95817-1460

USA024, Sacramento

93105-4353

USA078, Santa Barbara

80206-2761

USA075, Denver

06030

USA017, Farmington

32610-0001

USA076, Gainesville

32224-1865

USA082, Jacksonville

34748-5077

USA072, Leesburg

34102-5444

USA049, Naples

34239-3502

USA084, Sarasota

60611-2951

USA073, Chicago

46324-2213

USA115, Hammond

21224-3057

USA003, Baltimore

02114

USA079, Boston

01199

USA064, Springfield

08755

USA065, Toms River

11042-1102

USA066, New Hyde Park

10017-6739

USA021, New York

10032-3729

USA085, New York

28078-5082

USA096, Huntersville

37232-0028

USA109, Nashville

75246-2081

USA097, Dallas

75069-8085

USA050, McKinney

98664-1913

USA088, Vancouver

C1121ABE

ARG021, Ciudad Autónoma de Buenos Aires

C1122AAK

ARG022, Ciudad Autónoma de Buenos Aires

C1414AIF

ARG002, Ciudad Autónoma de Buenos Aires

C1425AZB

ARG001, Ciudad Autónoma de Buenos Aires

C1425BEN

ARG003, Ciudad Autónoma de BuenosAires

C1426ABP

ARG004, Ciudad Autónoma de BuenosAires

B1902COS

ARG006, La Plata

B7600FYK

ARG013, Mar del Plata

CP 7600

ARG017, Mar del Plata

B1853AIK

ARG009, Villa Vatteone

C10227AAP

ARG012, Buenos Aires

C1060

ARG018, Buenos Aires

C1425EFD

ARG026, Recoleta

M5544

ARG014, Vistalba

S2000DTC

ARG010, Rosario

T4000IFL

ARG015, San Miguel de Tucumán

T4000IHE

ARG025, San Miguel de Tucumán

X5003DCE

ARG005, Córdoba

M5500CCG

ARG007, Mendoza

S2000JKR

ARG011, Rosario

NSW 2139

AUS003, Concord

99010-120

BRA009, Passo Fundo

90035-074

BRA005, Porto Alegre

89030-240

BRA001, Blumenau

09090-790

BRA006, Santo André

18618-686

BRA003, Botucatu

09715-090

BRA004, São Bernardo do Campo

05403-000

BRA011, São Paulo

M5T 3A9

CAN004, Toronto

H2X 0A9

CAN002, Montreal

076001

COL004, Santiago de Cali

DK-2650

DNK001, Hvidovre

DK-8200

DNK007, Aarhus

04347

DEU003, Leipzig

06120

DEU016, Halle

01307

DEU014, Dresden

681 00

GRC003, Alexandroupoli

Dublin 8

IRL002, Dublin

V94 F858

IRL001, Limerick

00168

ITA009, Roma

470-1192

JPN029, Toyoake

791-0203

JPN031, Toon-Shi

815-0032

JPN027, Fukuoka

820-0018

JPN023, Iizuka-Shi

650-0047

JPN009, Kobe

309-1703

JPN020, Kasama-Shi

319-1113

JPN001, Naka-gun

761-8073

JPN022, Takamatsu

234-0054

JPN028, Yokohama-Shi Konan-Ku

861-1196

JPN005, Koshi Shi

515-8544

JPN008, Matsusaka-shi

514-1101

JPN011, Tsu

981-0914

JPN034, Sendai

852-8501

JPN013, Nagasaki

951-8510

JPN012, Chuo-ku

690-8556

JPN015, Matsue

204-8522

JPN007, Kiyose

143-8541

JPN014, Ōta-ku

140-8522

JPN006, Shinagawa-ku

141-8625

JPN017, Shinagawa-ku

160-8582

JPN002, Shinjuku-ku

750-0041

JPN019, Shimonoseki-Shi

434-8511

JPN003, Hamamatsu

807-8556

JPN004, Kita Kyushu-shi

690-8504

JPN016, Matsue

152-0021

JPN010, Meguro-ku

560-8552

JPN018, Toyonaka-shi

LV-5401

LVA002, Daugavpils

LV-2015

LVA005, Jūrmala

6815 AD

NLD003, Arnhem

1815 JD

NLD001, Alkmaar

1105 AZ

NLD002, Amsterdam

3015 GD

NLD006, Rotterdam

15-044

POL005, Bialystok

43-300

POL006, Bielsko-Biala

40-081

POL016, Katowice

25-751

POL015, Kielce

30-510

POL017, Krakow

95-054

POL018, Ksawerów

34-700

POL008, Rabka-Zdrój

35-051

POL011, Rzeszów

08-110

POL010, Siedlce

41-208

POL007, Sosnowiec

34-200

POL001, Sucha Beskidzka

70-111

POL014, Szczecin

33-100

POL009, Tarnów

27-400

POL012, Ostrowiec Świętokrzyski

3814-501

PRT005, Aveiro

4710-243

PRT009, Braga

6300-858

PRT006, Guarda

4835-044

PRT002, Guimarães

1649-035

PRT003, Lisbon

085 01

SVK002, Bardejov

052 01

SVK003, Spisská Nová Ves

05030

KOR003, Seoul

02447

KOR012, Seoul

02841

KOR011, Seoul

03312

KOR009, Seoul

03722

KOR013, Seoul

06273

KOR010, Seoul

06591

KOR005, Seoul

08036

ESP013, Badalona

08035

ESP003, Barcelona

08907

ESP006, L'Hospitalet de Llobregat

Unknown

ESP002, Madrid

01033

UKR008, Kyiv

03038

UKR004, Kyiv

CB23 3RE

GBR001, Cambridge

EX2 5DW

GBR015, Exeter

NR4 7UY

GBR017, Norwich

CF64 2XX

GBR013, Llandough, Penarth

BD9 6RJ

GBR016, Bradford

B9 5SS

GBR006, Birmingham

KT16 0PZ

GBR002, Chertsey

DDI 9SY

GBR007, Dundee

L14 3PE

GBR004, Liverpool

SW3 6NP

GBR009, London

M23 9LT

GBR008, Manchester

M8 5RB

GBR011, Manchester

NE7 7DN

GBR003, Newcastle upon Tyne

M6 8HD

GBR012, Salford

SO16 6YD

GBR018, Southampton

SA6 6NL

GBR010, Swansea

All Listed Sponsors
lead

Insmed Incorporated

INDUSTRY

NCT04594369 - A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis Bronchiectasis | Biotech Hunter | Biotech Hunter