Quantifying Body Composition and Liver Disease in Children Using Free-Breathing MRI and MRE

Enrolling by invitationOBSERVATIONAL
Enrollment

190

Participants

Timeline

Start Date

February 17, 2021

Primary Completion Date

January 31, 2026

Study Completion Date

January 31, 2026

Conditions
NAFLDNASH - Nonalcoholic Steatohepatitis
Interventions
DIAGNOSTIC_TEST

Magnetic resonance imaging (MRI)

Magnetic resonance imaging (MRI) is a non-invasive imaging technique that uses a magnetic field and radio waves to create detailed images of the organs and tissues within the body.

DIAGNOSTIC_TEST

Magnetic resonance elastography (MRE)

Magnetic resonance elastography (MRE) is a non-invasive imaging technique that uses a gently vibrating transducer in combination with MRI to create detailed images and maps of the mechanical properties, such as stiffness, of tissues within the body.

DEVICE

Prototype MRE soft flexible passive transducer paddle

The prototype device is provided to the investigators by Mayo Clinic under a Materials Transfer Agreement (MTA). The device is being used to promote comfort in the pediatric population; no formal data collection for regulatory submission is planned. The prototype device is smaller, softer, and more flexible than the commercial device and will be used where indicated by the subjects' size.

Trial Locations (1)

90095

UCLA Medical Center, Los Angeles

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

collaborator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

lead

University of California, Los Angeles

OTHER