515
Participants
Start Date
November 24, 2020
Primary Completion Date
August 3, 2021
Study Completion Date
August 3, 2021
Standard of care
Standard of care (SoC) treatment for COVID-19 infection in line with institutional practice. The SoC may change as new information becomes available about treating COVID-19.
Apremilast
Apremilast administered orally as a tablet.
Apremilast placebo
Matching apremilast placebo administered orally as a tablet.
Lanadelumab
Lanadelumab administered as an intravenous (IV) infusion.
Lanadelumab placebo
Matching lanadelumab placebo (normal saline) administered as an intravenous (IV) infusion.
Zilucoplan
Zilucoplan administered as a subcutaneous (sc) injection in the abdomen, thigh, or upper arm.
Zilucoplan placebo
Matching zilucoplan placebo administered as a subcutaneous (sc) injection in the abdomen, thigh, or upper arm.
Hospital San Juan de Dios, Ramos Mejía
Hospital Italiano de Rosario, Rosario
MERC SiReN, Johannesburg
Drs Sarvan and Moodley, Durban
Nelson Mandela Academic Clinical Research Unit (NeMACRU), Mthatha
Clinical Projects Research SA (PTY) LTD, Worcester
Dr JM Engelbrecht Trial Site, Somerset West
Tread Research, Cape Town
Tiervlei Trial Centre, Cape Town
2 Military Hospital Internal Medicine, Cape Town
CCH #1 Vinnytsia M.I.Pyrogov NMU Ch of Infectious Diseases, Vinnytsia
Hospital General de Tijuana, Tijuana
Grady Health System, Atlanta
Memorial Hospital Jacksonville, Jacksonville
UF Health Shands Hospital, Gainesville
Municipal Non-Profit Enterprise Central City Hospital Of Rivne City Council, Rivne
Pinnacle Research Group LLC, Anniston
University of Tennessee Health Sciences Center, Memphis
"Communal Non-Commercial Medical Enterprise O.T.Bohayevskyi Kremenchuk City Hospital #1", Kremenchuk
Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Guadalajara
Detroit Receiving Hospital, Royal Oak
Sinai Grace Hospital, Detroit
"Communal Noncommercial Profit Clinical City Hospital 16 of Dnipro Regional Council", Dnipro
The University of Iowa, Iowa City
Great Lakes Clinical Trials, Chicago
CNE of Kharkov RC Reg Cl Infectious Hospital, Kharkiv
Universidad Autonoma de Nuevo Leon, Hospital Universitario Dr. Jose Eleuterio Gonzalez, Monterrey
City Clinical infectious Hospital, Odesa
Texoma Medical Center, Sherman
Medical City Ft. Worth, Fort Worth
University of Texas Health Science Center at Houston, Houston
Hospital Civil de Culiacan, Culiacán
National Institute of Clinical Research, South El Monte
Sharp Chula Vista Medical Center, Chula Vista
El Centro Regional Medical Center, El Centro
University of California Irvine Medical Center, Orange
Good Samaritan Hospital, Bakersfield
University of California Davis Health System, Sacramento
MultiCare Health System Institute for Research and Innovation, Tacoma
"SBIH of Moscow Infectious Clinical Hospital # 1 of Department of Healthcare of Moscow", Moscow
"SPb SBIH Alexandrovskaya City Hospital", Saint Petersburg
St-George Hospital, Saint Petersburg
"SPb SBIH City Hospital # 40 of Kurortnyi region", Sestroretsk
"SPb SBIH Nikolaevskaya Hospital", Saint Petersburg
"SPb SBIH City Pokrovskaya Hospital", Saint Petersburg
"TSBIH Krasnoyarsk Interdistrict Clinical Hospital of Emergency Medical Care n.a. N.S. Karpovich", Krasnoyarsk
Hospital Base Osorno, Osorno
Riverside Community Hospital, Riverside
Harper University Hospital, Detroit
Hospital General de Agudos Dr. J. M. Ramos Mejia, Ciudad Autonoma Buenos Aires
Hospital General de Agudos Dr. Ignacio Pirovano, Ciudad Autonoma Buenos Aires
Clinica Adventista Belgrano, Ciudad Autonoma Buenos Aires
Chronos Pesquisa Clinica, Brasília
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás, Goiânia
Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte
Hospital de Clínicas de Porto Alegre, Porto Alegre
UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu, Botucatu
Praxis Pesquisa Médica, Santo André
Johese Clinical Research: Unitas, Centurion
Lead Sponsor
Amgen
INDUSTRY