920
Participants
Start Date
January 18, 2021
Primary Completion Date
September 25, 2032
Study Completion Date
September 25, 2032
Entrectinib
Adults and pediatric participants with a BSA ≥1.51 m\^2: entrectinib will be self-administered by participants orally at home at a dose of 600 mg/day (three 200-mg capsules per day). Pediatric participants with a BSA \< 1.51 m\^2: entrectinib will be administered orally at home in mini-tablet formulation at a dose of 400 mg/day (BSA=1.11-1.50 m\^2) or 300 mg/day (BSA=0.81-1.10 m\^2) or 200 mg/day (BSA=0.51-0.80 m\^2) or 300 milligrams per square meter (mg/m\^2) (BSA=0.43-0.50 m\^2).
Entrectinib
Adults and pediatric participants with a BSA ≥ 1.51 m\^2: entrectinib will be self-administered by participants orally at home at a dose of 600 mg/day (three 200-mg capsules per day). Pediatric participants with a BSA \< 1.51 m\^2: entrectinib will be administered orally at home in mini-tablet formulation at a dose of 400 mg/day (BSA=1.11-1.50 m\^2) or 300 mg/day (BSA=0.81-1.10 m\^2) or 200 mg/day (BSA=0.51-0.80 m\^2) or 300 mg/m\^2 (BSA=≤0.50 m\^2).
Alectinib
Alectinib will be administered orally BID with food at a dosage of 600 mg (four 150-mg capsules).
Atezolizumab
Atezolizumab will be administered by IV infusion at a fixed dose of 1200 mg for participants aged ≥18 years, and 15 mg/kg (maximum 1200 mg) for participants aged \<18 years on Day 1 of each 21-day cycle.
Ipatasertib
For participants 12-17 years of age, ipatasertib will be administered at the starting dose of 200 mg for participants \< 35 kg, 300 mg for participants ≥35 and \< 45 kg, 400 mg for those ≥ 45 kg orally QD, beginning of Cycle 1, on Days 1-21 of each 28-day cycle until the participant experiences disease progression, intolerable toxicity, or withdraws consent.
Trastuzumab emtansine
Trastuzumab emtansine will be administered at 3.6 mg/kg by IV infusion every 21 days until disease progression or unacceptable toxicity. The dosage and administration method also applies for pediatric participants 12-17 years of age.
Inavolisib
GDC-077 will be administered QD at a starting dose of 9 mg PO in repeated 28-day cycles. The dosage and administration method also applies for pediatric participants 12-17 years of age.
Belvarafenib
Belvarafenib will be administered at a dose 400 mg, PO, BID with adequate water (more than 200 mL). One cycle consists of 28 days. Administration of belvarafenib should occur BID on every day of each 28-day cycle.
Pralsetinib
Pralsetinib will be self-administered by participants orally at home (except on clinic days) on a continuous daily dosing regimen at a dose of 400 mg/day (four 100-mg capsules per day) for adult and pediatric participants ≥ 12 and \< 18 years of age. A treatment cycle consists of 4 weeks (28 days).
Divarasib
Divarasib will be self-administered by participants orally at home (except on clinic days) on a continuous daily dosing regimen for both adult and pediatric participants. A treatment cycle consists of 3 weeks (21 days).
Camonsertib
Camonsertib will be self-administered by participants orally at home (except on clinic days). A treatment cycle consists of 3 weeks and will be given on days 1-3 and days 8-10 of every 21-day cycle.
RECRUITING
Chang Gung Memorial Hospital-Linkou, Taoyuan
RECRUITING
Auckland City Hospital, Cancer and Blood Research, Auckland
RECRUITING
Cliniques Universitaires St-Luc, Brussels
COMPLETED
Kinghorn Cancer Centre, Darlinghurst
WITHDRAWN
Sydney Children's Hospital, Randwick
ACTIVE_NOT_RECRUITING
Rigshospitalet, København Ø
WITHDRAWN
Medical Oncology Centre of Rosebank, Johannesburg
WITHDRAWN
UZ Antwerpen, Edegem
COMPLETED
Peter MacCallum Cancer Centre, Melbourne
ACTIVE_NOT_RECRUITING
UZ Leuven Gasthuisberg, Leuven
ACTIVE_NOT_RECRUITING
Inselspital, Klinik und Poliklinik für Medizinische Onkologie, Bern
RECRUITING
Royal Children's Hospital, Parkville
WITHDRAWN
Universitätsspital Basel (USB), Basel
RECRUITING
Princess Alexandra Hospital, Woolloongabba
COMPLETED
GHdC Site Les Viviers, Charleroi
WITHDRAWN
Ospedale Regionale di Bellinzona Medizin Onkologie, Bellinzona
WITHDRAWN
Unversitätsspital Zürich, Zurich
WITHDRAWN
Aarhus Universitetshospital, Aarhus N
RECRUITING
UZ Gent, Ghent
WITHDRAWN
National Translational Research Group, New York
COMPLETED
Icahn School of Medicine at Mount Sinai, New York
ACTIVE_NOT_RECRUITING
National Taiwan University Hospital, Zhongzheng Dist.
RECRUITING
Dipartimento di Scienze Pediatriche Adolescenza, Turin
TERMINATED
Montefiore Einstein Center for Cancer Care, The Bronx
WITHDRAWN
Eastchester Center for Cancer Care, The Bronx
TERMINATED
Memorial Sloan Kettering Cancer Center, New York
WITHDRAWN
New York Cancer and Blood Specialists - Setauket Medical Oncology, Port Jefferson Station
ACTIVE_NOT_RECRUITING
Hopital de la Timone, Marseille
ACTIVE_NOT_RECRUITING
Seoul National University Bundang Hospital, Gyeonggi-do
COMPLETED
Consultants in Medical Oncology and Hematology, Broomall
RECRUITING
Alliance Cancer Specialists, Horsham
COMPLETED
Cancer Treatment Centers of America, Philadelphia
WITHDRAWN
The Children's Hospital of Philadelphia, Philadelphia
WITHDRAWN
Christiana Care Health Srvcs, Newark
RECRUITING
Irccs Istituto Nazionale Dei Tumori (Int), Milan
RECRUITING
Istituto Nazionale Tumori di Milano, Milan
COMPLETED
Virginia Cancer Specialists - Leesburg, Leesburg
WITHDRAWN
Universitätsklinikum Hamburg-Eppendorf Onkologisches Zentrum Medizinische Klinik II, Hamburg
TERMINATED
Maryland Hematology & Oncology. P.A., Silver Spring
ACTIVE_NOT_RECRUITING
Asst Degli Spedali Civili Di Brescia, Brescia
RECRUITING
Hospital Infantil Universitario Nino Jesus, Madrid
RECRUITING
Clinica Universidad de Navarra Madrid, Madrid
RECRUITING
START Madrid-FJD, Hospital Fundacion Jimenez Diaz, Madrid
RECRUITING
Hospital Universitario 12 de Octubre, Madrid
RECRUITING
Hospital Universitario La Paz, Madrid
RECRUITING
START Madrid. Centro Integral Oncologico Clara Campal, Madrid
WITHDRAWN
PRISMA Health - Greenville, Greenville
COMPLETED
University Cancer & Blood Center, LLC, Athens
WITHDRAWN
Medizinische Hochschule Zentrum Innere Medizin Abt.Gastroenterologie, Endokrinologie und Hepatologie, Hanover
ACTIVE_NOT_RECRUITING
Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse
WITHDRAWN
University of Florida, Gainesville
ACTIVE_NOT_RECRUITING
Institut Bergonie, Bordeaux
WITHDRAWN
Miami Cancer Institute of Baptist Health, Inc., Miami
WITHDRAWN
Ocala Oncology Center, Ocala
WITHDRAWN
Southern Cancer Center, Daphne
COMPLETED
Georg-August-Uniklinik, Göttingen
ACTIVE_NOT_RECRUITING
St. Jude Children'S Research Hospital, Memphis
COMPLETED
The West Clinic, Germantown
WITHDRAWN
Taichung Veterans General Hospital, Taichung
COMPLETED
Praxis für Hämatologie, Onkologie und Palliativmedizin, Mönchengladbach
COMPLETED
Uniklinik Essen, Essen
COMPLETED
Barrett Cancer Center, Cincinnati
COMPLETED
Oncology Hematology Care Inc, Cincinnati
RECRUITING
Hospital Universitario la Fe, Valencia
COMPLETED
Horizon Oncology Research, Inc., Lafayette
WITHDRAWN
St. Joseph Mercy Hospital, Ann Arbor
TERMINATED
Henry Ford Health System, Detroit
WITHDRAWN
Azienda Ospedaliera Meyer, Florence
RECRUITING
Azienda Ospedaliera Universitaria Senese, U.O.C. Immunoterapia Oncologica, Siena
RECRUITING
Froedtert and The Medical College of Wisconsin, Milwaukee
RECRUITING
Metro-Minnesota Community Oncology Research Consortium, Saint Louis Park
WITHDRAWN
University of Minnesota, Minneapolis
ACTIVE_NOT_RECRUITING
Centre Oscar Lambret, Lille
TERMINATED
Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana, Billings
TERMINATED
Midwestern Regional Med Center, Zion
WITHDRAWN
Washington University, St Louis
WITHDRAWN
Nebraska Methodist Hospital, Omaha
ACTIVE_NOT_RECRUITING
Centre Leon Berard, Lyon
ACTIVE_NOT_RECRUITING
SLK-Kliniken Heilbronn GmbH;Klinik für Innere Medizin III, Heilbronn
RECRUITING
Mary Crowley Medical Research Center, Dallas
TERMINATED
Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas
COMPLETED
Texas Oncology- Northeast Texas, Tyler
WITHDRAWN
Cook Childrens Medical Center, Fort Worth
RECRUITING
Texas Oncology - Central South, Austin
WITHDRAWN
Children's Hospital Colorado, Aurora
WITHDRAWN
Istituto Nazionale Tumori Fondazione G. Pascale, Napoli
WITHDRAWN
Klinikum der Universität München, Campus Großhadern, München
COMPLETED
St. Alphonsus, Boise
COMPLETED
Western Regional Medical Center at Cancer Treatment Centers of America, Goodyear
TERMINATED
University of New Mexico, Albuquerque
WITHDRAWN
Universtitätsklinikum Ulm, Ulm
WITHDRAWN
Comprehensive Cancer Centers of Nevada - Eastern Avenue, Las Vegas
ACTIVE_NOT_RECRUITING
Kaiser Permanente Los Angeles, Los Angeles
COMPLETED
USC Norris Cancer Center, Los Angeles
WITHDRAWN
Sarcoma Oncology Center, Santa Monica
WITHDRAWN
City of Hope National Medical Center, Duarte
COMPLETED
Hoag Memorial Hospital, Newport Beach
WITHDRAWN
University of California at San Francisco, San Francisco
ACTIVE_NOT_RECRUITING
Institut de Cancerologie Gustave-Roussy (IGR), Villejuif
COMPLETED
UC Davis Comprehensive Cancer Center, Sacramento
WITHDRAWN
Uniklinikum, Comprehensive Cancer Center Mainfranken, Würzburg
WITHDRAWN
Providence Portland Medical Center, Portland
COMPLETED
Northwest Medical Specialties, PLLC, Tacoma
RECRUITING
Beijing Cancer Hospital, Beijing
RECRUITING
Taipei Veterans General Hospital, Taipei
RECRUITING
National University Hospital, Singapore
WITHDRAWN
The First Hospital of Jilin University, Changchun
WITHDRAWN
Jilin Cancer Hospital, Changchun
ACTIVE_NOT_RECRUITING
National Cancer Centre, Singapore
RECRUITING
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai
WITHDRAWN
Shanghai East Hospital, Shanghai
RECRUITING
Tianjin Cancer Hospital, Tianjin
RECRUITING
West China Hospital - Sichuan University, Chengdu
RECRUITING
First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an
RECRUITING
Rambam Health Care Campus, Haifa
RECRUITING
Rabin MC, Petah Tikva
RECRUITING
Sheba Medical Center, Ramat Gan
RECRUITING
Sourasky / Ichilov Hospital, Tel Aviv
RECRUITING
Hadassah University Hospital - Ein Kerem, Jerusalem
WITHDRAWN
New England Cancer Specialists, Scarborough
WITHDRAWN
Dartmouth Hitchcock Medical Center, Lebanon
TERMINATED
Rutgers Cancer Institute of New Jersey, New Brunswick
RECRUITING
The University of Texas MD Anderson Cancer Center, Houston
WITHDRAWN
Royal Darwin Hospital, Tiwi
WITHDRAWN
Hospital Moinhos de Vento, Porto Alegre
WITHDRAWN
Hospital Sírio-Libanês, São Paulo
RECRUITING
Hospital Sírio-Libanês, São Paulo
ACTIVE_NOT_RECRUITING
Hospital A. C. Camargo, São Paulo
RECRUITING
Clínica Onco Star - Rede D'Or, São Paulo
RECRUITING
BC Cancer ? Vancouver, Vancouver
WITHDRAWN
London Health Sciences Centre · Victoria Hospital, London
RECRUITING
The Ottawa Hospital - General Campus, Ottawa
RECRUITING
The Hospital for Sick Children, Toronto
WITHDRAWN
Princess Margaret Cancer Center, Toronto
WITHDRAWN
McGill University Health Center, Montreal
RECRUITING
Beijing Children's Hospital, Capital Medical University, Beijing
RECRUITING
Zhongshan Hospital Fudan Unvierstiy, Shanghai
RECRUITING
Hong Kong Children's Hospital, Hong Kong
RECRUITING
Prince of Wales Hospital, Shatin
RECRUITING
Ospedale Pediatrico Bambino Gesù - IRCCS, Rome
ACTIVE_NOT_RECRUITING
Policlinico Universitario Agostino Gemelli IRCCS, Rome
WITHDRAWN
National Cancer Center Hospital East, Chiba
COMPLETED
Kindai University Hospital, Osaka
COMPLETED
National Cancer Center Hospital, Tokyo
ACTIVE_NOT_RECRUITING
Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii, Gda?sk
RECRUITING
Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad, Warsaw
RECRUITING
IPO do Porto, Porto
COMPLETED
PanOncology Trials, San Juan
RECRUITING
Seoul National University Hospital- Adult Site, Seoul
RECRUITING
Seoul National University Hospital- Pediatric Site, Seoul
COMPLETED
Severance Hospital, Yonsei University Health System, Seoul
ACTIVE_NOT_RECRUITING
Asan Medical Center, Seoul
ACTIVE_NOT_RECRUITING
Samsung Medical Center- Adult Site, Seoul
RECRUITING
Samsung Medical Center- Pediatric Site, Seoul
RECRUITING
Hospital Sant Joan De Deu, Esplugues de Llobregas
RECRUITING
Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Barcelona
RECRUITING
Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona
RECRUITING
National Cheng Kung University Hospital, Tainan City
COMPLETED
Beatson West of Scotland Cancer Centre, Glasgow
COMPLETED
University College London Hospital, London
WITHDRAWN
Guys and St Thomas NHS Foundation Trust, Guys Hospital, London
WITHDRAWN
Royal Manchester Children?s Hospital, Manchester
COMPLETED
The Christie NHS Foundation Trust, Manchester
Hoffmann-La Roche
INDUSTRY