Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery

PHASE3TerminatedINTERVENTIONAL
Enrollment

19

Participants

Timeline

Start Date

August 5, 2021

Primary Completion Date

August 6, 2024

Study Completion Date

August 6, 2024

Conditions
Anatomic Stage IV Breast Cancer AJCC v8Metastatic Lung Non-Small Cell CarcinomaMetastatic Lung Small Cell CarcinomaMetastatic Malignant Breast NeoplasmMetastatic Malignant Digestive System NeoplasmMetastatic Malignant Neoplasm in the BrainMetastatic Malignant Solid NeoplasmMetastatic MelanomaMetastatic Renal Cell CarcinomaRecurrent Brain NeoplasmStage IV Lung Cancer AJCC v8Stage IV Renal Cell Cancer AJCC v8
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Memantine

Given PO

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Ancillary studies

RADIATION

Stereotactic Radiosurgery

Undergo SRS/fSRS

RADIATION

Whole-Brain Radiotherapy

Undergo HA-WBRT

Trial Locations (81)

11042

Northwell Health/Center for Advanced Medicine, Lake Success

13210

State University of New York Upstate Medical University, Syracuse

13478

Upstate Cancer Center at Verona, Verona

14642

University of Rochester, Rochester

15232

UPMC-Shadyside Hospital, Pittsburgh

15601

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

17408

UPMC Memorial, York

17822

Geisinger Medical Center, Danville

17837

Geisinger Medical Oncology-Lewisburg, Lewisburg

17901

Geisinger Cancer Services-Pottsville, Pottsville

19063

Riddle Memorial Hospital, Media

19096

Lankenau Medical Center, Wynnewood

19317

Christiana Care Health System-Concord Health Center, Chadds Ford

19713

Delaware Clinical and Laboratory Physicians PA, Newark

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

21014

UM Upper Chesapeake Medical Center, Bel Air

21044

Central Maryland Radiation Oncology in Howard County, Columbia

21061

UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

21237

MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

26506

West Virginia University Healthcare, Morgantown

27157

Wake Forest University Health Sciences, Winston-Salem

29425

Medical University of South Carolina, Charleston

29605

Prisma Health Cancer Institute - Faris, Greenville

33028

Memorial Hospital West, Pembroke Pines

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

39216

University of Mississippi Medical Center, Jackson

43210

Ohio State University Comprehensive Cancer Center, Columbus

48106

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48114

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

48118

Chelsea Hospital, Chelsea

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48197

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

53051

Froedtert Menomonee Falls Hospital, Menomonee Falls

53095

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend

53154

Drexel Town Square Health Center, Oak Creek

53226

Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62401

Carle Physician Group-Effingham, Effingham

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

73104

University of Oklahoma Health Sciences Center, Oklahoma City

79410

Covenant Medical Center-Lakeside, Lubbock

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

90503

City of Hope South Bay, Torrance

91010

City of Hope Comprehensive Cancer Center, Duarte

91030

City of Hope South Pasadena, South Pasadena

91786

City of Hope Upland, Upland

92618

City of Hope at Irvine Lennar, Irvine

92882

City of Hope Corona, Corona

93534

City of Hope Antelope Valley, Lancaster

94115

California Pacific Medical Center-Pacific Campus, San Francisco

95661

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

Sutter Roseville Medical Center, Roseville

95816

Sutter Medical Center Sacramento, Sacramento

32224-9980

Mayo Clinic in Florida, Jacksonville

02111

Tufts Medical Center, Boston

H2X 3E4

CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal

Unknown

Pamela Youde Nethersole Eastern Hospital, Chai Wan

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NRG Oncology

OTHER