Effect of Epidural Anesthesia and Analgesia on Quality of Recovery After Radical Prostatectomy.

PHASE4CompletedINTERVENTIONAL
Enrollment

61

Participants

Timeline

Start Date

April 1, 2019

Primary Completion Date

April 1, 2021

Study Completion Date

June 1, 2021

Conditions
AnesthesiaAnesthesia Recovery PeriodRadical ProstatectomyPatient SatisfactionPostoperative PeriodQuality of LifeAnalgesiaEpiduralQuality of Recovery
Interventions
PROCEDURE

Epidural anesthesia with light general anesthesia

Epidural anaesthesia: mixture of ropivacaine 6.5 mg/ ml and fentanyl 8.3 μg/ml. Light general anesthesia: isoflurane in mixture of 50/50 of nitrous oxide and oxygen to achieve Minimum alveolar concentration between 0.6 and 0.8.

DRUG

Postoperative epidural analgesia

Before the end of operation was given 4 ml of the mixture of ropivacaine 4.4 mg/ml and morphine 0.8mg/ ml. Epidural analgesia was continued for next 24 hours with a mixture of ropivacaine 2.2 mg/ml and morphine 0.4 mg/ml.

PROCEDURE

General anesthesia

Maintaining general anesthesia: nitrous oxide and oxygen in mixture 50/50 and isoflurane to achieve minimum alveolar concentration between 0.8 and 1. Fentanyl loading dose: 6-8 μg/kg. Additional fentanyl doses were given incrementally.

DRUG

Continuous intravenous analgesia

Tramadol 100 mg in the first hour followed by tramadol 300 mg continuously for the next 24 hours.

Trial Locations (1)

21000

University Hospital Split, Split

All Listed Sponsors
lead

University Hospital of Split

OTHER

NCT04587505 - Effect of Epidural Anesthesia and Analgesia on Quality of Recovery After Radical Prostatectomy. | Biotech Hunter | Biotech Hunter