A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

708

Participants

Timeline

Start Date

February 25, 2021

Primary Completion Date

February 11, 2026

Study Completion Date

February 11, 2027

Conditions
Carcinoma, Renal Cell
Interventions
DRUG

Belzutifan

Immediate-release 40 mg tablet

DRUG

Lenvatinib

Capsule available in 4 mg and 10 mg dosages

DRUG

Cabozantinib

Tablet available in 20 mg, 40 mg and 60 mg dosages

Trial Locations (184)

1020

Krankenhaus der Barmherzigen Brüder Wien ( Site 1041), Vienna

1070

Institut Jules Bordet ( Site 1103), Anderlecht

1090

Medizinische Universität Wien ( Site 1021), Vienna

1160

Klinik Ottakring-1.Medizinische Abteilung - Zentrum für Onkologie und Hämatologie ( Site 1031), Vienna

1200

Cliniques Universitaires Saint Luc - Bruxelles ( Site 1105), Brussels

1211

Hopitaux Universitaires de Geneve HUG ( Site 1602), Geneva

1280

Hospital Británico de Buenos Aires-Oncology ( Site 0801), Ciudad Autónoma de Buenos Aires

2000

Sanatorio Británico-Clinical Oncology Department ( Site 0802), Rosario

2065

GenesisCare North Shore ( Site 4011), St Leonards

3000

Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 4010), Melbourne

UZ Leuven ( Site 1101), Leuven

3199

Peninsula Health Frankston Hospital ( Site 4001), Frankston

4000

CHU de Liege ( Site 1102), Liège

4020

Ordensklinikum Linz GmbH Elisabethinen-Urologie ( Site 1001), Linz

5112

Lyell McEwin Hospital ( Site 4004), Elizabeth Vale

6000

Grand Hopital de Charleroi ( Site 1104), Charleroi

6500

Istituto Oncologica della Svizzera Italiana (IOSI) ( Site 1604), Bellinzona

7000

Kantonsspital Graubuenden ( Site 1600), Chur

8001

Universitaetsspital Zuerich ( Site 1601), Zurich

8036

Medizinische Universitätsklinik Graz ( Site 1051), Graz

9000

UZ Gent ( Site 1100), Ghent

10043

Ospedale San Luigi Gonzaga ( Site 1405), Orbassano

10065

Memorial Sloan Kettering Cancer Center ( Site 0055), New York

10117

Charite Universitaetsmedizin Berlin ( Site 1321), Berlin

11042

R.J. Zuckerberg Cancer Center-Medical Oncology ( Site 0013), Lake Success

13125

HELIOS Klinikum Berlin-Buch ( Site 1311), Berlin

15006

Complejo Hospitalario Universitario A Coruna ( Site 1502), A Coruña

18103

Lehigh Valley Hospital- Cedar Crest-Oncology Clinical Trials ( Site 0056), Allentown

20007

Georgetown University Medical Center ( Site 0006), Washington D.C.

20089

Istituto Clinico Humanitas Research Hospital ( Site 1406), Rozzano

20132

IRCCS Ospedale San Raffaele ( Site 1409), Milan

20133

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1400), Milan

20520

TYKS ( Site 1802), Turku

24014

Blue Ridge Cancer Care - Roanoke ( Site 0043), Roanoke

26504

UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 3302), Pátrai

27100

Istituti Clinici Scientifici Maugeri Spa ( Site 1403), Pavia

27710

Duke Cancer Institute ( Site 0096), Durham

28009

Hospital General Universitario Gregorio Maranon ( Site 1505), Madrid

28040

Hospital Clinico San Carlos ( Site 1504), Madrid

28041

Hospital Universitario 12 de Octubre-Medical Oncology ( Site 1508), Madrid

28204

Levine Cancer Institute ( Site 0004), Charlotte

30322

Emory University Hospital ( Site 0012), Atlanta

30607

University Cancer & Blood Center, LLC ( Site 0057), Athens

31059

Institut Claudius Regaud ( Site 1215), Toulouse

32804

AdventHealth Orlando-AdventHealth Medical Group Hematology & Oncology at Orlando ( Site 0003), Orlando

32806

Orlando Health, Inc. ( Site 0035), Orlando

33075

CHU de Bordeaux- Hopital Saint Andre ( Site 1209), Bordeaux

33520

Tampereen yliopistollinen sairaala ( Site 1801), Tampere

37126

Ospedale Maggiore Borgo Trento ( Site 1408), Verona

39213

University of Mississippi Medical Ctr ( Site 0037), Jackson

40207

Norton Cancer Institute - St. Matthews ( Site 0065), Louisville

41013

Hospital Virgen del Rocio ( Site 1503), Seville

44805

Institut de Cancerologie de l Ouest Centre Rene Gauducheau ( Site 1201), Saint-Herblain

46845

Parkview Cancer Institute ( Site 0088), Fort Wayne

47014

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori ( Site 1407), Meldola

49055

Institut de Cancerologie de l Ouest Site Paul Papin ( Site 1200), Angers

49503

Cancer & Hematology Centers of Western Michigan ( Site 0018), Grand Rapids

51726

Institut Jean Godinot ( Site 1216), Reims

52074

Universitaetsklinikum Aachen AOER ( Site 1317), Aachen

52100

Medical Oncology Ospedale San Donato ( Site 1404), Arezzo

55426

HealthPartners Cancer Research Center-HealthPartners Frauenshuh Cancer Center ( Site 0005), Saint Louis Park

58128

Chonnam National University Hwasun Hospital-Oncology ( Site 4203), Hwasun

60590

Universitaetsklinikum Frankfurt ( Site 1301), Frankfurt am Main

60607

Rush University Medical Center ( Site 0040), Chicago

61615

Illinois Cancer Care, PC ( Site 0008), Peoria

66421

Universitaetsklinikum des Saarlandes ( Site 1305), Homburg/ Saar

67200

Institut de cancérologie Strasbourg Europe (ICANS) ( Site 1218), Strasbourg

68510

Cancer Partners of Nebraska ( Site 0086), Lincoln

69120

NCT-Department of Medical Oncology ( Site 1320), Heidelberg

70112

Tulane University School of Medicine ( Site 0098), New Orleans

70124

Azienda Ospedaliera Policlinico di Bari ( Site 1402), Bari

75020

Hopital Tenon ( Site 1213), Paris

79106

Klinik fuer Urologie ( Site 1303), Freiburg im Breisgau

85224

Ironwood Cancer & Research Centers ( Site 0077), Chandler

87039

Clinique Francois Chenieux ( Site 1210), Limoges

90048

Cedars Sinai Medical Center ( Site 0027), Los Angeles

90404

UCLA Hematology/Oncology - Santa Monica ( Site 0048), Los Angeles

Providence Saint John's Health Center ( Site 0083), Santa Monica

90419

Klinikum Nuernberg Nord ( Site 1300), Nuremberg

92868

St. Joseph Hospital-The Center for Cancer Prevention and Treatment ( Site 0095), Orange

UC Irvine Health ( Site 0029), Orange

98109

Seattle Cancer Care Alliance-Renal/Melanoma/MCC ( Site 0093), Seattle

99089

Helios Klinikum Erfurt GmbH ( Site 1315), Erfurt

111511

Instituto Nacional de Cancerología-Clinical Oncology ( Site 0500), Bogotá

119285

FSBI United Hospital with Polyclinic ( Site 2613), Moscow

121205

Hadassah Medical-Oncology department ( Site 2609), Moscow

125130

SHI of Moscow City Oncology Clinical Hospital - 62 ( Site 2614), Moscow

143442

MEDSI Clinical Hospital on Pyatnitsky Highway-Departmentof Antitumor Drug therapy ( Site 2618), Krasnogorsk

150054

Yaroslavl Regional Cancer Hospital-Oncology ( Site 2619), Yaroslavl

153040

Ivanovo Regional Oncology Dispensary ( Site 2616), Ivanovo

200001

Sociedad De Oncologia Y Hematologia Del Cesar-Oncology ( Site 0508), Valledupar

200542

"Centrul de Oncologie Sfântul Nectarie ( Site 2502)", Craiova

400015

Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 2500), Cluj-Napoca

Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 2501), Cluj-Napoca

404120

Volgograd Regional Uronephrological Center ( Site 2615), Volzhsky

681017

Fundación Cardiovascular de Colombia ( Site 0501), Piedecuesta

1138519

Tokyo Medical and Dental University Hospital ( Site 5009), Bunkyo-ku

2360004

Yokohama City University Hospital ( Site 5007), Yokohama

2778577

National Cancer Center Hospital East ( Site 5000), Kashiwa

4780000

James Lind Centro de Investigación del Cáncer ( Site 0402), Temuco

8420383

Bradfordhill-Clinical Area ( Site 0400), Santiago

59151600

Liga Norte Riograndense Contra o Cancer ( Site 0313), Natal

01805

Lahey Hospital & Medical Center ( Site 0090), Burlington

08901

Rutgers Cancer Institute of New Jersey ( Site 0078), New Brunswick

75390-7208

University of Texas, Southwestern Medical Center ( Site 0015), Dallas

84112-5500

Huntsman Cancer Institute-HCI Clinical Trials Office ( Site 7001), Salt Lake City

05401

University of Vermont Medical Center ( Site 0001), Burlington

Washington

"Confluence Health , Wenatchee Valley Hospital & Clinics ( Site 0061)"

C1120AAT

Centro de Urología (CDU) ( Site 0803), CABA

C1426ANZ

Instituto Alexander Fleming ( Site 0800), Ciudad Autónoma de Buenos Aires

S2000DSV

Sanatorio Parque ( Site 0806), Rosario

C1419AHN

Asociación de Beneficencia Hospital Sirio Libanés ( Site 0804), Buenos Aires

90110-270

Centro Gaucho Integrado de Oncologia ( Site 0304), Porto Alegre

01321-001

BP - A Beneficencia Portuguesa de São Paulo-Medical Oncology ( Site 0311), São Paulo

Hospital Paulistano - Amil Clinical Research ( Site 0308), São Paulo

T2N 4N2

Tom Baker Cancer Centre ( Site 0109), Calgary

T6G 1Z2

Cross Cancer Institute ( Site 0111), Edmonton

V5Z 4E6

BC Cancer Vancouver-Clinical Trials Unit ( Site 0110), Vancouver

E1C 6Z8

The Moncton Hospital ( Site 0101), Moncton

L8V 5C2

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0114), Hamilton

K7L 2V7

Kingston Health Sciences Centre ( Site 0105), Kingston

K1H 8L6

The Ottawa Hospital - General Campus-The Ottawa Hospital Cancer Centre ( Site 0116), Ottawa

M4N 3M5

Sunnybrook Health Sciences - Odette Cancer Centre ( Site 0113), Toronto

J4V 2H1

CISSS de la Monteregie-Centre ( Site 0103), Greenfield Park

G1J 1Z4

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0, Québec

J1H 5N4

CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0102), Sherbrooke

050030

Fundación Colombiana de Cancerología Clínica Vida ( Site 0505), Medellín

656 53

Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 2203), Brno

370 01

Nemocnice České Budějovice-Onkologicke oddeleni ( Site 2204), České Budějovice

140 59

Fakultni Thomayerova nemocnice-Onkologicka klinika 1. LF UK ( Site 2200), Prague

150 06

Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 2205), Prague

500 05

Fakultni nemocnice Hradec Kralove-Klinika onkologie a radioterapie ( Site 2201), Hradec Králové

00290

HYKS ( Site 1800), Helsinki

06189

Centre Antoine Lacassagne ( Site 1217), Nice

06120

Krankenhaus Martha Maria Halle-Doelau ( Site 1314), Halle

115 28

Alexandra General Hospital of Athens-ONCOLOGY DEPT. ( Site 3304), Athens

151 25

Athens Medical Center ( Site 3303), Athens

124 62

ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 3301), Chaïdári

570 01

European Interbalkan Medical Center-Oncology Department ( Site 3300), Thessaloniki

D07 R2WY

Mater Misericordiae University Hospital ( Site 3201), Dublin

D24NR0A

Tallaght University Hospital ( Site 3200), Dublin

Dublin 7

Mater Private Hospital - Dublin ( Site 3202), Dublin

00168

Fondazione Policlinico Universitario Agostino Gemelli-Medical Oncology ( Site 1410), Roma

05100

Azienda Ospedaliera S. Maria di Terni ( Site 1401), Terni

470-1192

Fujita Health University ( Site 5003), Toyoake

285-8741

Toho University Sakura Medical Center ( Site 5014), Sakura

060-8543

Sapporo Medical University Hospital ( Site 5008), Sapporo

650-0047

Kobe City Medical Center General Hospital ( Site 5017), Kobe

634-8522

Nara Medical University Hospital ( Site 5002), Kashihara

589-8511

Kindai University Hospital- Osakasayama Campus-Urology ( Site 5010), Sayama

565-0871

Osaka University Hospital ( Site 5012), Suita

431-3192

Hamamatsu University School of Medicine University Hospital ( Site 5004), Hamamatsu

105-8470

Toranomon Hospital ( Site 5001), Minato-ku

812-8582

Kyushu University Hospital ( Site 5005), Fukuoka

951-8520

Niigata University Medical & Dental Hospital ( Site 5013), Niigata

541-8567

Osaka International Cancer Institute ( Site 5016), Osaka

113-8603

Nippon Medical School Hospital ( Site 5006), Tokyo

123-8558

Tokyo Women's Medical University Adachi Medical Center ( Site 5015), Tokyo

160-8582

Keio university hospital ( Site 5011), Tokyo

6162 BG

Zuyderland Medical Centre-Trialbureau Interne Geneeskunde ( Site 1904), Sittard-Geleen

4818 CK

Amphia Hospital Location Molengracht ( Site 1912), Breda

1066 CX

Antoni van Leeuwenhoek Ziekenhuis ( Site 1901), Amsterdam

8934 AD

Medisch Centrum Leeuwarden ( Site 1905), Leeuwarden

GD 3015

Erasmus MC ( Site 1913), Rotterdam

3118 JH

Franciscus Gasthuis & Vlietland, Locatie Vlietland ( Site 1909), Schiedam

2545 AA

Haga Ziekenhuis locatie Leyweg-Oncology ( Site 1917), The Hague

3584CX

Universitair Medisch Centrum Utrecht ( Site 1910), Utrecht

60-569

Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 2401), Poznan

85-796

Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 2402), Bydgoszcz

31-115

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - O-Klinika Onkologii Klinicznej ( Site 240, Krakow

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 2400), Warsaw

05505

Asan Medical Center ( Site 4200), Seoul

06351

Samsung Medical Center ( Site 4201), Seoul

08035

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1507), Barcelona

08036

Hospital Clinic i Provincial ( Site 1500), Barcelona

08041

Hospital Santa Creu i Sant Pau ( Site 1501), Barcelona

AB25 2ZN

Aberdeen Royal Infirmary-Department of Oncology ( Site 3105), Aberdeen

BA1 3NG

Royal United Hospital Bath England ( Site 3108), Bath

NG5 1PF

Nottingham University Hospitals NHS Trust. City Hospital Campus ( Site 3106), Nottingham

SS0 0RY

Southend University Hospital ( Site 3112), Southend

W6 8RF

Imperial Healthcare NHS Trust Charing Cross Hospital ( Site 3107), London

HA6 2RN

Mount Vernon Cancer Centre ( Site 3101), Northwood

TA1 5DA

Musgrove Park Hospital ( Site 3103), Taunton

SA2 8QA

Singleton Hospital ( Site 3111), Swansea

All Listed Sponsors
collaborator

Eisai Inc.

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT04586231 - A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011) | Biotech Hunter | Biotech Hunter