A Study to Assess Intrahepatic and Peripheral Changes of Immunologic and Virologic Markers in Chronic Hepatitis B Virus Infection

PHASE2CompletedINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

March 11, 2021

Primary Completion Date

February 8, 2023

Study Completion Date

January 9, 2024

Conditions
Hepatitis B
Interventions
DRUG

JNJ-73763989

JNJ-73763989 will be administered subcutaneously once every 4 weeks up to Week 44.

DRUG

JNJ-56136379

JNJ-56136379 tablets will be administered orally once daily up to 48 weeks.

DRUG

Entecavir (ETV)

ETV tablet will be administered orally once daily up to 48 weeks as NA treatment.

DRUG

Tenofovir disoproxil

Tenofovir disoproxil will be administered orally once daily up to 48 weeks as NA treatment.

DRUG

Tenofovir alafenamide (TAF)

TAF will be administered orally once daily up to 48 weeks as NA treatment.

DRUG

PegIFN-alpha-2a (Optional)

PegIFN-alpha-2a injection will be administered subcutaneously once weekly after Week 40 for either 12 or 24 weeks.

Trial Locations (10)

1010

New Zealand Clinical Research, Auckland

2650

UZ Antwerpen, Edegem

20122

Irccs Ospedale Maggiore Di Milano, Milan

21287

Johns Hopkins University, Baltimore

92110

Hopital Beaujon, Clichy

ON M5G 2C4

Toronto General Hospital, Toronto

D-20246

University Medical Center, Hamburg

41-400

ID Clinic, Mysłowice

E1 1BB

Grahame Hayton Unit, London

SE5 9RF

Kings College Hospital, London

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY

NCT04585789 - A Study to Assess Intrahepatic and Peripheral Changes of Immunologic and Virologic Markers in Chronic Hepatitis B Virus Infection | Biotech Hunter | Biotech Hunter