PreOperative Endocrine Therapy for Individualised Care With Abemaciclib

PHASE3RecruitingINTERVENTIONAL
Enrollment

2,032

Participants

Timeline

Start Date

December 23, 2020

Primary Completion Date

September 30, 2030

Study Completion Date

March 31, 2032

Conditions
Breast Cancer Female
Interventions
DRUG

Abemaciclib

Abemaciclib used in combination with standard Endocrine Therapy for 2 years from randomisation

DRUG

Endocrine therapy (letrozole, anastrozole, exemestane or tamoxifen)

Standard of care endocrine therapy for a minimum of 5 years from randomisation

Trial Locations (62)

Unknown

RECRUITING

Royal Cornwall Hospital, Truro

RECRUITING

Royal Devon & Exeter Hospital, Exeter

RECRUITING

Northampton General Hospital, Northampton

RECRUITING

Belfast City Hospital, Belfast

RECRUITING

Aberdeen Royal Infirmary, Aberdeen

RECRUITING

Wansbeck General Hospital, Ashington

RECRUITING

Ysbyty Gwynedd, Bangor

RECRUITING

Royal United Hospital Bath, Bath

RECRUITING

Blackpool Victoria Hospital, Blackpool

RECRUITING

Pilgrim Hospital, Boston

RECRUITING

Royal Bournemouth Hospital, Bournemouth

RECRUITING

Royal Sussex County Hospital, Brighton

ACTIVE_NOT_RECRUITING

Doncaster Royal Infirmary, Doncaster

RECRUITING

Dumfries and Galloway Royal Infirmary, Dumfries

RECRUITING

Ninewells Hospital, Dundee

RECRUITING

Western General Hospital, Edinburgh

RECRUITING

The Beatson West of Scotland Cancer Centre, Glasgow

RECRUITING

Calderdale Royal Hospital, Halifax

RECRUITING

Harrogate District Hospital, Harrogate

RECRUITING

Huddersfield Royal Infirmary, Huddersfield

RECRUITING

Kettering General Hospital, Kettering

RECRUITING

Kingston Hospital, Kingston upon Thames

RECRUITING

University Hospitals of Morecambe Bay, Lancaster

RECRUITING

St James's University Hospital, Leeds

RECRUITING

Lincoln County Hospital, Lincoln

RECRUITING

St John's Hospital, Livingston

RECRUITING

Barnet and Chase Farm Hospitals, London

RECRUITING

Charing Cross Hospital, London

RECRUITING

Royal Free Hospital, London

RECRUITING

Royal Marsden NHS Foundation Trust, London

RECRUITING

St George's Hospital, London

RECRUITING

University College London, London

RECRUITING

Maidstone and Tunbridge Wells NHS Trust, Maidstone

RECRUITING

North Manchester General Hospital, Manchester

RECRUITING

The Christie Hospital, Manchester

RECRUITING

Wythenshawe Hospital, Manchester

RECRUITING

Borders General Hospital, Melrose

RECRUITING

Milton Keynes University Hospital, Milton Keynes

RECRUITING

North Tyneside General Hospital, North Shields

RECRUITING

George Eliot Hospital NHS Trust, Nuneaton

RECRUITING

University Hospital Llandough, Penarth

RECRUITING

Poole General Hospital, Poole

RECRUITING

Royal Berkshire Hospital, Reading

RECRUITING

East Surrey Hospital, Redhill

RECRUITING

Glan Clwyd, Rhyl

RECRUITING

Royal Shrewsbury Hospital, Shrewsbury

RECRUITING

University Hospitals of North Tees and Hartlepool, Stockton-on-Tees

RECRUITING

Royal Stoke University Hospital, Stoke-on-Trent

RECRUITING

Royal Marsden Hospital, Sutton

RECRUITING

Musgrove Park Hospital, Taunton

RECRUITING

Warwick Hospital, Warwick

RECRUITING

Royal Albert Edward Infirmary, Wigan

RECRUITING

Worcestershire Acute Hospitals NHS Trust, Worcester

PE30 4ET

RECRUITING

Queen Elizabeth Hospital, Kings Lynn

SN3 6BB

RECRUITING

Great Western Hospital, Swindon

FK5 4WR

RECRUITING

Forth Valley Royal Hospital, Larbert

GU2 7XX

RECRUITING

Royal Surrey County Hospital, Guildford

BB2 3HH

RECRUITING

Royal Blackburn Hospital, Blackburn

BB10 2PQ

RECRUITING

Burnley General Hospital, Burnley

IP4 5PD

RECRUITING

Ipswich Hospital, Ipswich

SO166YD

RECRUITING

Southampton General Hospital, Southampton

WF1 4DG

RECRUITING

Mid Yorkshire -Pinderfields Hospital, Wakefield

All Listed Sponsors
lead

Institute of Cancer Research, United Kingdom

OTHER

NCT04584853 - PreOperative Endocrine Therapy for Individualised Care With Abemaciclib | Biotech Hunter | Biotech Hunter