MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS)

PHASE2TerminatedINTERVENTIONAL
Enrollment

249

Participants

Timeline

Start Date

September 30, 2020

Primary Completion Date

March 31, 2023

Study Completion Date

July 13, 2023

Conditions
Amyotrophic Lateral SclerosisMotor Neuron Disease
Interventions
DRUG

Pegcetacoplan (APL-2)

Complement (C3) Inhibitor

OTHER

Placebo

Sterile solution of equal volume to active arm

Trial Locations (60)

2050

Brain and Mind Centre, Camperdown

2250

Central Coast Neurosciences Research, Erina

3084

Nueor-Immunology Clinical Researh Education and Support Service (N-CRESS), Austin Health, Heidelberg

4029

Royal Brisbane and Women's Hospital, Herston

4215

Gold Coast University Hospital, Southport

6300

CHU de Nice Hôpital Pasteur, Nice

10021

Hospital for Special Surgery, New York

10126

Azienda Ospedaliera Universitaria di Torino - Città della Salute e della Scienza di Torino, Torino

18147

Universitätsmedizin Rostock, Klinik und Poliklinik für Neurologie, Rostock

20162

Ospedale Niguarda - Nemo Clinical Center - Fondazione Serena Onlus, Milan

21205

Johns Hopkins, Baltimore

30625

Medizinische Hochschule Hannover Klinik für Neurologie, Hanover

30912

Augusta University, Augusta

33076

Hopital Pellegrin, Bordeaux

33612

University of South Florida, Tampa

41126

Ospedale Civile S. Agostino Estense di Modena, Azienda Ospedaliero Universitaria di Modena, Modena

46026

Hospital Universitari I Politecnic La Fe, Valencia

46202

Indiana University, Indianapolis

55415

The Berman Center, Minneapolis

59037

Hôpital Roger Salengro, Lille

61068

SI Institute of Neurology, Psychiatry and Narcology of NAMSU, Kharkiv

63000

CHU Gabriel Montpied, Clermont-Ferrand

65062

Centre of Reconstructive and Restorative Medicine (University Clinic) Odessa National Medical University, Odesa

69600

Zaporizhzhya Regional Clinical Hospital, Zaporizhzhya

69677

Hôpital Neurologique Pierre Wertheimer, Bron

78756

Austin Neuromuscular Center, Austin

80045

University of Colorado, Aurora

87042

CHU de Limoges Dupuytren 1, Limoges

89081

University of Ulm, Ulm

90048

Cedars-Sinai Medical Center, Los Angeles

90129

"AOUP P. Giaccone", Palermo

05401

University of Vermont Medical Center, Burlington

B-9000

AZ Sint-Lucas & Volkskliniek, Ghent

B-3000

Universitaire Ziekenhuizen Leuven (UZ Leuven), Leuven

128 21

Vseobecna fakultni nemocnice v Praze, Prague

160 00

FORBELI s.r.o., Prague

D-13353

Charité - Universitätsmedizin Berlin, Berlin

07747

Universitätsklinikum Jena, Jena

DO9 V2NO

Beaumont Hospital, Dublin

465-8620

National Hospital Organization Higashinagoya National Hospital, Aichi

837-0911

National Hospital Organization Omuta National Hospital, Fukuoka

070-8644

National Hospital Organization Asahikawa Medical Center, Hokkaido

669-1592

National Hospital Organization Hyogo-Chuo National Hospital, Hyōgo

920-0192

National Hospital Organization Iou National Hospital, Ishikawa

399-8701

National Hospital Organization Matsumoto Medical Center, Matsumoto

945-8585

Niigata National Hospital National Hospital Organization, Niigata

901-2214

National Hospital Organization Okinawa National Hospital, Okinawa

349-0196

National Hospital Organization Higashisaitama National Hospital, Saitama

420-8688

Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka

113-8431

Juntendo University Hospital, Tokyo

160-0023

Tokyo Medical University Hospital, Tokyo

3584 CX

University Medical Center Utrecht, Utrecht

10-082

Uniwersytecki Szpital Kliniczny w Olsztynie Klinika Neurologii, Olsztyn

01-684

Centrum Medyczne NeuroProtect, Warsaw

02-473

City Clinic Sp. z o.o., Warsaw

08035

Hospital Universitari Vall d'Hebron, Barcelona

08907

Bellvitge University Hospital, Barcelona

BN2 5BE

University Hospitals Sussex NHS Foundation Trust, Brighton

SE5 9RX

Maurice Wohl Clinical Neuroscience Institute, King's College London, London

SW17 0WT

St George's University Hospitals NHS Foundation Trust, London

Sponsors
All Listed Sponsors
lead

Apellis Pharmaceuticals, Inc.

INDUSTRY