A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment

PHASE3RecruitingINTERVENTIONAL
Enrollment

320

Participants

Timeline

Start Date

April 12, 2021

Primary Completion Date

June 30, 2028

Study Completion Date

June 30, 2028

Conditions
Myelofibrosis
Interventions
DRUG

Imetelstat

Imetelstat sodium will be given intravenously at 9.4 mg/kg every 21 days, until disease progression or unacceptable toxicity, treatment discontinuation or study end.

DRUG

Best Available Therapy (BAT)

Non-JAK-inhibitor treatment will be given, which may include but is not limited to hydroxyurea, thalidomide or an analog of thalidomide, interferon, danazol, hypomethylating agents, chemotherapy or radiotherapy.

Trial Locations (220)

186

TERMINATED

"Ltd Medinvest - Institute of Hematology and Trans", Tbilisi

404

RECRUITING

China Medical University Hospital - Hematology/Onc, Taichung

613

RECRUITING

Chang Gung Medical Foundation, Chiayi City

1088

WITHDRAWN

Semmelweis Egyetem - III. sz., Budapest

1130

RECRUITING

Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel, Wein

1307

RECRUITING

Universitätsklinikum Carl Gust, Dresden

1756

TERMINATED

Specialized Hospital for Active Therapy of Hematological dis, Sofia

2020

WITHDRAWN

Zna - Campus Middelheim, Antwerp

2060

WITHDRAWN

ZNA Stuyvenberg Antwerpen, Antwerp

2065

RECRUITING

Royal North Shore Hospital, St Leonards

2650

TERMINATED

UZ Antwerpen, Edegem

2930

RECRUITING

AZ Klina, Antwerp

3121

RECRUITING

Epworth Healthcare, Richmond

3722

TERMINATED

Severance Hospital, Yonsei Uni, Seoul

4002

TERMINATED

UMBAL Sveti Georgi, Plovdiv

4011

RECRUITING

Royal Brisbane and Women's Hospital, Herston

4020

RECRUITING

Krankenhaus der Elisabethinen, Linz

4021

RECRUITING

Kepler Universitätsklinikum Gm, Linz

4400

RECRUITING

Szabolcs-Szatmár-Bereg Megyei Önkormányzat Jósa András, Nyíregyháza

4600

RECRUITING

Klinikum Wels-Grieskirchen GmbH, Wels

5800

WITHDRAWN

"UMHAT Dr. Georgi Stranski", Pleven

6120

RECRUITING

Martin-Luther-Universität Halle-Wittenberg, Halle

6351

RECRUITING

Samsung Medical Center, Seoul

6590

RECRUITING

Ankara University Medical Facu, Ankara

6591

RECRUITING

The Catholic University of Korea, Seongdong

7000

RECRUITING

Royal Hobart Hospital, Hobart

7100

RECRUITING

Centre Hospitalier de Jolimont, Haine-Saint-Paul

8000

WITHDRAWN

Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz -, Székesfehérvár

9000

RECRUITING

Universitair Ziekenhuis Gent, Ghent

10003

RECRUITING

H. San Pedro de Alcántara, Cáceres

10029

RECRUITING

Icahn School of Medicine at Mount Sinai, New York

10043

RECRUITING

AOU San Luigi Gonzaga, Orbassano

10126

RECRUITING

AOU Città della Salute e della Scienza di Torino, Torino

10408

RECRUITING

National Cancer Institute Center for Cancer Research, Goyang-si

10990

RECRUITING

Hospital Pulau Pinang, Pulau Pinang

11490

RECRUITING

Tri-Service General Hospital, Taipei

13057

WITHDRAWN

Hematology-Oncology Associates of Central New York (HOACNY), East Syracuse

15121

RECRUITING

PO Civile SS.Antonio e Biagio, Alessandria

15586

RECRUITING

Hospital Raja Perempuan Zainab II, Kota Bharu

16132

RECRUITING

IRCCS Ospedale Policlinico San Martino, Genova

17007

RECRUITING

ICO-Hospital Universitari de G, Girona

17403

WITHDRAWN

Cancer Care Associates of York, York

18014

RECRUITING

Hospital Universitario Virgen, Granada

20089

RECRUITING

Istituto Clinico Humanitas Roz, Rozzano

20122

RECRUITING

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan

20132

RECRUITING

Ospedale San Raffaele, Milan

20162

RECRUITING

ASST Grande Ospedale Metropoli, Milan

20850

TERMINATED

Maryland Oncology Hematology, Rockville

20900

RECRUITING

Azienda Ospedaliera San Gerard, Monza

21100

RECRUITING

Ospedale di Circolo, PO Varese, Varese

21565

RECRUITING

Gachon University Gil Medical Center, Incheon

22100

RECRUITING

Western Galilee Hospital - Nahariya, Nahariya

22408

TERMINATED

Hematology Oncology Associates of Fredericksburg, Fredericksburg

24105

WITHDRAWN

Universitätsklinikum Schleswig, Kiel

27710

RECRUITING

Duke University Medical Center, Durham

28040

RECRUITING

Hospital Universitario Fundaci, Madrid

28041

RECRUITING

Hospital U. 12 Octubre, Madrid

28046

RECRUITING

H.U. La Paz, Madrid

29010

RECRUITING

H.U.V. de la Victoria, Málaga

29603

WITHDRAWN

H. Comarcal Costa del Sol, Málaga

29609

RECRUITING

CHRU Brest - Hôpital Morvan, Brest

30029

RECRUITING

Institut de cancérologie du Gard - Hematologie clinique, Nîmes

31048

RECRUITING

Bnai Zion Medical Center, Haifa

33110

WITHDRAWN

Mersin University Medical Faculty, Yenisehir/Mersin

33326

RECRUITING

BRCR Medical Center Inc, Plantation

33612

RECRUITING

University of South Florida, Tampa

34098

RECRUITING

Istanbul üniversitesi cerrahpaşa, Istanbul

34214

RECRUITING

Medipol Bagcilar Mega Hospital, Istanbul

34711

WITHDRAWN

Clermont Oncology, Clermont

34899

RECRUITING

Marmara university pendik training and research hospital, Istanbul

35019

RECRUITING

Hospital Universitario de Gran, Las Palmas de Gran Canaria

35100

RECRUITING

Ege Universitesi Tip Fakultesi, Izmir

36100

RECRUITING

Ospedale S.Bortolo, AULSS n.6, Vicenza

37007

RECRUITING

Hospital Universitario de Salamanco, Salamanca

37044

RECRUITING

CHU Bretonneau, Tours

40138

RECRUITING

A.O.di Bologna Policl.S.Orsola, Bologna

40207

RECRUITING

Norton Cancer Institute, Louisville

41944

WITHDRAWN

Kyungpook National University Hospital - Hematolog, Daegu

42123

RECRUITING

Arcispedale S Maria Nuova, AO di Reggio Emilia, Reggio Calabria

42271

RECRUITING

CHU de Saint Etienne, Loiré

43214

WITHDRAWN

Ohio Health, Columbus

43537

WITHDRAWN

Taylor Cancer Research Center, Maumee

44093

RECRUITING

CHU De Nantes - Hématologie C, Nantes

44124

RECRUITING

Arcispedale S.Anna - Ematologi, Cona

44718

RECRUITING

Gabrail Cancer Center, Canton

46017

WITHDRAWN

Hospital Universitario Doctor Peset, Valencia

46526

WITHDRAWN

Goshen Center for Cancer Care, Goshen

46600

RECRUITING

H.U. Ribera de Alzira, Alzira

46804

WITHDRAWN

Fort Wayne Medical Oncology and Hematology, Fort Wayne

47014

RECRUITING

Irccs Irst, Meldola

47392

RECRUITING

Inje University Busan Paik Hos, Busan

47900

RECRUITING

AUSL di Rimini Ospedale Infermi di Rimini, Rimini

48108

RECRUITING

Inje University Haeundae Paik Hospital, Busan

48121

RECRUITING

Ospedale Civile S.Maria delle Croci, AUSL Ravenna, Ravenna

49241

RECRUITING

Pusan National University Hospital - Hematology and Oncology, Busan

49372

WITHDRAWN

Tel Aviv Sourasky Medical Cent, Tel Aviv

50012

RECRUITING

H. Quirón Zaragoza, Zaragoza

50134

RECRUITING

AOU Careggi, Florence

54100

RECRUITING

Sakarya Research and Training Hospital - Medical Oncology, Adapazarı

57104

WITHDRAWN

Sanford Health, Sioux Falls

57105

WITHDRAWN

Avera Cancer Institute, Sioux Falls

57201

RECRUITING

Prairie Lakes Health Care System, Inc., Watertown

63141

WITHDRAWN

Mercy Health, St Louis

64506

WITHDRAWN

Mosaic Life Care, Saint Joseph

65807

WITHDRAWN

Oncology Hematology Associates, Springfield

68000

RECRUITING

Hospital Ampang, Ampang

68130

WITHDRAWN

Nebraska Cancer Specialists, Omaha

68167

RECRUITING

Universitätsklinikum Mannheim - University of Heidelberg, Mannheim

69310

RECRUITING

Centre Hospitalier Lyon, Pierre-Bénite

70124

TERMINATED

Ochsner Clinic Foundation, New Orleans

70433

WITHDRAWN

ONCare Alliance - Pontchartrain, Covington

70808

WITHDRAWN

Our Lady of the Lake Cancer Institute, Baton Rouge

72037

RECRUITING

Centre Hospitalier Du Mans - Cancérologie Médicale, Le Mans

72076

RECRUITING

Universitätsklinikum Tübingen, Tübingen

74605

RECRUITING

Hospital das Clínicas UFG, Goiânia

75010

RECRUITING

CHU - Hôpital Saint Louis - Centre D'Investigations Cliniq, Paris

75679

RECRUITING

Hopital Cochin - Aphp Hôpitaux Universitaires Paris Centre, Paris

77024

TERMINATED

Oncology Consultants, Houston

78278

RECRUITING

Barzilai Medical Center, Ashkelon

80000

RECRUITING

Hospital Sultanah Aminah Johor Bahru, Johor Bahru

80122

RECRUITING

AOU Federico II, Napoli

84101

RECRUITING

Soroka Medical Center - Hematology Institute, Beersheba

84106

TERMINATED

Utah Cancer Specialists, Salt Lake City

84405

TERMINATED

Community Cancer Trials of Utah, Ogden

84902

RECRUITING

Hospital CENTRE HOSPITALIER AVIGNON, Avignon

87042

RECRUITING

CHU de Limoges Dupuytren, Haute-Vienne

87439

RECRUITING

Klinikum Kempten-Oberallgaeu GmbH, Kempten

89124

RECRUITING

Azienda Ospedaliera Bianchi-Me, Reggio Calabria

89511

WITHDRAWN

Cancer Care Specialists of Reno, Reno

90096

RECRUITING

UCLA David Geffen School of Medicine, Los Angeles

90720

WITHDRAWN

Cancer and Blood Research Center, Los Alamitos

90806

WITHDRAWN

Memorial Care, Long Beach

93009

RECRUITING

Hopital Avicenne - Hématologie Clinique, Bobigny

93586

RECRUITING

Sarawak General Hospital, Kuching

94270

RECRUITING

Hopital Bicetre, Paris

95122

RECRUITING

Presidio Ospedaliero Garibaldi, Catania

96701

WITHDRAWN

Hawaii Cancer Care, ‘Aiea

97301

WITHDRAWN

Oregon Oncology Specialists, Salem

98405

WITHDRAWN

Northwest Medical Specialties PLLC, Tacoma

110029

SUSPENDED

All India Institute of Medical Sciences, Dept. of Hematology, New Delhi (All India Institute Of Medical Sciences), New Delhi

110060

RECRUITING

Sir Ganga Ram Hospital, New Delhi

119074

RECRUITING

National University Cancer Institute (NCIS), Singapore

122002

RECRUITING

Fortis Memorial Research Institute, Gūrgaon

129110

TERMINATED

MONIKI - Oncology, Moscow

169608

RECRUITING

Singapore General Hospital, Singapore

197022

WITHDRAWN

First Saint-Petersburg State Medical University n., Saint Petersburg

197341

WITHDRAWN

V.A. Almazov National Medical Research Center, Saint Petersburg

300053

WITHDRAWN

Tula Regional Clinical Hospital, Tula

395002

RECRUITING

Nirmal Hospital - Hematology, Surat

410012

ACTIVE_NOT_RECRUITING

GOU VPO Saratov State Medical University n.a. V.I., Saratov

411004

RECRUITING

Deenanath Mangeshkar Hospital & Research Center, Pune

420076

RECRUITING

Centro Medico Imbanaco de Cali S.A., Santiago de Cali

560076

RECRUITING

Fortis Hospital 154/9, Bengaluru

560099

RECRUITING

Narayana Hrudayalaya Hospital, Hyderabad

630091

ACTIVE_NOT_RECRUITING

MUZ City Clinical Hospital # 2, Novosibirsk

644013

ACTIVE_NOT_RECRUITING

Budgetary Healthcare Institution of Omsk Region, Omsk

660000

RECRUITING

Oncologos del Occidente S.A, Pereira

700014

SUSPENDED

Nilratan Sircar Medical College, Kolkata

751019

RECRUITING

All India Institute of Medical Sciences, Bhubaneswar

3436212

RECRUITING

Carmel MC, Haifa

7030000

RECRUITING

Shamir Medical Center (Assaf Harofeh), Ẕerifin

7610001

RECRUITING

Kaplan Medical Center, Rehovot

7747629

RECRUITING

Assuta Ashdod University Hospi, Ashdod

9112001

RECRUITING

Hadassah Medical Organization, Jerusalem

60135285

RECRUITING

Centro de oncologia Leonardo da Vinci, Fortaleza

90470340

RECRUITING

Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa LTDA, Porto Alegre

92093-1503

RECRUITING

University of California-San Diego/Moores UCSD Cancer Center, La Jolla

06511

RECRUITING

Smilow Cancer Center at YNHH, New Haven

77030-4000

RECRUITING

The University of Texas MD, Houston

C118AAT

RECRUITING

Hospital Aleman, Ciudad de Buenos Aires

S2000ORE

RECRUITING

Sanatorio de la Mujer, Rosario

X5000JHQ

RECRUITING

Sanatorio Allende, Córdoba

04000

WITHDRAWN

CHU De Liège, Liège

Unknown

RECRUITING

Universitair Ziekenhuis Brussel - Myeloom Centrum Brussel (MCB), Jette

RECRUITING

Hospital A.C.Camargo Cancer Center - Clinical Oncology, São Paulo

RECRUITING

Hospital Pablo Tobon Uribe, Antioquia

RECRUITING

FOSCAL, Floridablanca

RECRUITING

Sahyadri Specialty Hospital, Pune

RECRUITING

Medical Park Mersin Hastanesi, Mersin

81520-060

RECRUITING

Hospital Erasto Gaertner, Curitiba

90035-903

RECRUITING

Hospital de Clinicas de Porto Alegre - UFRGS, Porto Alegre

88034-000

RECRUITING

CEPON Centro de Pesquisas Oncologicas SC, Florianópolis

01323000

RECRUITING

Instituto de Educação, Pesquisa e Gestão em Saúde, São Paulo

05651-901

RECRUITING

Hospital Israelita Albert Einstein, São Paulo

17210-120

RECRUITING

Fundacao Doutor Amaral Carvalho / Hospital Amaral Carvalho, São Paulo

DK-5000 C

RECRUITING

Odense University Hospital - Hematology, Odense

06202

RECRUITING

CHU de Nice - Hopital de l'Archet II - Pharmacie, Nice

0112

RECRUITING

LTD Israeli-Georgian Medical R, Tbilisi

TERMINATED

M.Zodelava Hematology Center L, Tbilisi

0159

RECRUITING

"J.S.C.K.Eristavi National Cen", Tbilisi

0179

RECRUITING

Multi Profile Clinic Consilium, Tbilisi

04103

RECRUITING

Universitätsklinikum Leipzig AöR, Leipzig

H-1097

WITHDRAWN

Dél-pesti Centrumkórház Ország, Budapest

560 034

RECRUITING

St. John's Medical College Hospital, Bangalore

6- 16132

RECRUITING

Clinica Ematologica, Univ. Deg, Genova

00144

RECRUITING

"ASL Roma 2 - PO S. Eugenio", Roma

00168

RECRUITING

Policlinico Universitario Agostino Gemelli, Roma

64-920

TERMINATED

Ars Medical Sp. z o.o., Piła

60-185

RECRUITING

Centrum Medyczne Pratia Poznan, Skórzewo

76-200

WITHDRAWN

Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Sl, Słupsk

40-519

RECRUITING

Pratia Onkologia Katowice, Katowice

21-500

RECRUITING

Wojewodzki Szpital Specjalistyczny, Biała Podlaska

4710-243

RECRUITING

CCA-Braga. Centro Clínico Académico - Hospital Braga, Braga

3000-075

WITHDRAWN

CHUC - Centro Hospitalar e Universitário de Coimbr, Coimbra

1099-023

RECRUITING

Instituto Português de Oncologia de Lisboa, Lisbon

1400-038

RECRUITING

Centro Clinico Fundacao Champalimaud, Lisbon

1495-005

RECRUITING

H. São Francisco Xavier-Centro, Lisbon

1649-035

RECRUITING

H. Santa Maria. Centro Hospita, Lisbon

02841

RECRUITING

Korea University Anam Hospital, Seoul

06273

WITHDRAWN

Gangnam Severance Hospital, Yonsei University Health System, Seoul

08308

RECRUITING

Korea University Guro Hospital, Seoul

03080

RECRUITING

Seoul National University Hospital - Department of Internal, Seoul

08916

RECRUITING

Institut Català d'Oncologia-Ho, Badalona

08208

RECRUITING

C.S. Parc Tauli, Sabadell

03010

RECRUITING

H.G.U. Alicante, Alicante

06560

RECRUITING

Gazi University Medical Faculty, Ankara

ME16 9QQ

WITHDRAWN

Maidstone Hospital, Maidstone

EC1A 7BE

RECRUITING

St Bartholomew's Hospital, London

SE1 9RT

RECRUITING

Guys and St Thomas' Hospital, London

OX3 9DS

TERMINATED

Oxford University Hospitals, Oxford

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Geron Corporation

INDUSTRY

NCT04576156 - A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment | Biotech Hunter | Biotech Hunter