Post-operative Analgesic Effect of Oral Nefopam

PHASE2RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

June 29, 2021

Primary Completion Date

June 30, 2026

Study Completion Date

November 15, 2026

Conditions
Postoperative Pain After a Total Knee Arthroplasty
Interventions
DRUG

Oral nefopam

Oral administration of nefopam 60mg 2 hours before the surgery following by 60mg each 8h for 24h. Oral nefopam is prepared ex-tempore from the intravenous formulation adding a taste masking compound by a non-caring nurse following detailed instructions.

DRUG

Placebo

Oral administration of a placebo 2 hours before the surgery following by one administration each 8h for 24h. Oral placebo is prepared ex-tempore with a taste masking compound by a non-charge nurse following detailed instructions

Trial Locations (1)

69004

RECRUITING

Département d'Anesthésie Réanimation, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon

All Listed Sponsors
lead

Hospices Civils de Lyon

OTHER