Imaging of the Neural Correlates of Arousal and Awareness

NANot yet recruitingINTERVENTIONAL
Enrollment

85

Participants

Timeline

Start Date

November 15, 2020

Primary Completion Date

November 15, 2020

Study Completion Date

November 15, 2025

Conditions
Lesional Coma
Interventions
OTHER

Multimodal evaluation of brain function : PET-MRI, electrophysiology, eye-tracking

"After 2 days of sedation withdrawal, each data should be collected within 3 days for organisation purposes :~1. After installation and movement management with standardized routine care protocol: 18Fluoro-Desoxy-Glucose's infusion for PET~2. Starting PET continuous acquisition~3. Morphological MRI sequences~4. MRI in Resting state N°1~5. MRI DTI acquisition~6. IRM in 2D-Arterial Spin Labelling~7. IRM in Resting state 2~8. End of PET continuous acquisition The day before or the day after PET-MR: standard 20 min EEG, somaesthetic evoked potentials, auditory evoked potentials, mismatch negativity, P300 oddball paradigm, local-global paradigm, P300 after music stimulation, EEG resting state for 10 min, CRS-R repeated before each examination (and at least 5 times for chronic patients), eye-tracking study of the environmental exploration."

Trial Locations (1)

69500

Hôpital Neurologique Pierre Wertheimer, Bron

All Listed Sponsors
lead

Hospices Civils de Lyon

OTHER

NCT04575454 - Imaging of the Neural Correlates of Arousal and Awareness | Biotech Hunter | Biotech Hunter