Pilot Study of Chemotherapy for HPV-Associated Oropharyngeal Cancer

Participants assigned to this group will receive transoral robotic surgery (TORs) or radiotherapy. Radiotherapy is given once a day for 5 weeks. A percentage of subjects who undergo surgery may need further radiotherapy with or without chemotherapy based on the results of the surgery. TORs is surgery in which a robot with arms is used to remove cancer from hard-to-reach areas of the mouth and throat.

Participants assigned to this group will receive 5 weeks of chemotherapy combined with low- dose radiotherapy.

Participants assigned to this group will receive 7 weeks of chemotherapy combined with high- dose radiotherapy.

This drug will be combined with carboplatin during induction therapy for 9 weeks.

This drug will be combined with paclitaxel during induction therapy for 9 weeks.