Study of Zifibancimig in Participants With Neovascular Age-related Macular Degeneration

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

251

Participants

Timeline

Start Date

October 28, 2020

Primary Completion Date

February 11, 2027

Study Completion Date

December 30, 2028

Conditions
Macular Degeneration
Interventions
DRUG

Zifibancimig

"Part 1: multiple ascending doses by IVT injection. Each participant will receive zifibancimig at a constant volume of 50 microliter in the study eye.~Part 2: participants will be randomized to one of two dose levels of zifibancimig in the PD implant.~Part 3: Participants will receive one of the two dose levels of zifibancimig in the PD implant."

DRUG

Ranibizumab

Participants will receive ranibizumab 100 mg/mL through the PD implant

DEVICE

Port Delivery Platform

Participants will receive intraocular refillable device that is surgically inserted into the eye for continuous delivery of drugs into the vitreous.

Trial Locations (53)

11590

RECRUITING

Long Is. Vitreoretinal Consult, Westbury

13088

RECRUITING

Retina Vit Surgeons/Central NY, Liverpool

19107

RECRUITING

Mid Atlantic Retina - Wills Eye Hospital, Philadelphia

20815

RECRUITING

Retina Group of Washington, Chevy Chase

21209

RECRUITING

The Retina Care Center, Baltimore

21287

RECRUITING

Johns Hopkins Med, Baltimore

21740

RECRUITING

Cumberland Valley Retina Consultants, Hagerstown

23502

RECRUITING

Wagner Kapoor Institute, Norfolk

24502

RECRUITING

Piedmont Eye Center, Lynchburg

27705

RECRUITING

Duke Eye Center, Durham

28602

RECRUITING

Graystone Eye, Hickory

29464

RECRUITING

Carolina Eyecare Physicians, Mt. Pleasant

30909

RECRUITING

Southeast Retina Center, Augusta

32308

RECRUITING

Southern Vitreoretinal Assoc, Tallahassee

32503

RECRUITING

Retina Specialty Institute, Pensacola

33609

RECRUITING

Retina Associates of Florida, LLC, Tampa

33711

RECRUITING

Retina Vitreous Assoc of FL, St. Petersburg

37203

RECRUITING

Tennessee Retina PC., Nashville

37922

RECRUITING

Southeastern Retina Associates, Knoxville

38138

RECRUITING

Charles Retina Institute, Germantown

39456

RECRUITING

Charleston Neuroscience Inst, Ladson

43212

RECRUITING

OSU Eye Physicians & Surgeons, Columbus

44195

RECRUITING

The Cleveland Clinic Foundation, Cleveland

48073

RECRUITING

Associated Retinal Consultants, Royal Oak

49546

RECRUITING

Foundation for Vision Research, Grand Rapids

55416

RECRUITING

VitreoRetinal Surgery, PLLC., Saint Louis Park

60452

RECRUITING

University Retina and Macula Associates, PC, Oak Forest

63017

RECRUITING

Midwest Vision Research Foundation, Chesterfield

63128

RECRUITING

The Retina Institute, St Louis

75231

RECRUITING

Texas Retina Associates, Dallas

76092

RECRUITING

Retina Center of Texas, Southlake

77030

ACTIVE_NOT_RECRUITING

Retina Consultants of Texas, Houston

77401

RECRUITING

Retina & Vitreous of Texas, Bellaire

ACTIVE_NOT_RECRUITING

Retina Consultants of Texas, Bellaire

78705

RECRUITING

Austin Research Center for Retina, Austin

78750

RECRUITING

Austin Clinical Research LLC, Austin

79606

RECRUITING

Retina Res Institute of Texas, Abilene

81303

RECRUITING

Southwest Retina Consultants, Durango

84107

RECRUITING

Retina Associates of Utah, PLLC, Salt Lake City

85020

ACTIVE_NOT_RECRUITING

Associated Retina Consultants, Phoenix

85206

RECRUITING

Barnet Dulaney Perkins Eye Center, Mesa

89502

ACTIVE_NOT_RECRUITING

Sierra Eye Associates, Reno

91436

RECRUITING

The Retina Partners, Encino

92705

RECRUITING

Orange County Retina Med Group, Santa Ana

94109

WITHDRAWN

West Coast Retina Medical Group, San Francisco

95841

RECRUITING

Retinal Consultants Med Group, Sacramento

99204

RECRUITING

Spokane Eye Clinical Research, Spokane

90503-3270

RECRUITING

Macula Retina Vitreous Research Institute, Torrance

04101

RECRUITING

Maine Eye Center, Portland

07003

ACTIVE_NOT_RECRUITING

Envision Ocular, LLC, Bloomfield

07666-1704

RECRUITING

NJ Retina - Teaneck, Teaneck

78251-4551

RECRUITING

Brown Retina Institute, San Antonio

00612

RECRUITING

Emanuelli Research and Development Center LLC, Arecibo

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY