NCT04561063 - COVID-19 Prophylaxis South Africa (COVER HCW) | Biotech Hunter

Enrollment

1,950

Participants

Timeline

Start Date

December 8, 2020

Primary Completion Date

February 28, 2022

Study Completion Date

February 28, 2022

Conditions

Covid19SARS-CoV Infection

Interventions

DRUG

Nitazoxanide

Nitozoxanide 1 tablet (500 mg) taken 12-hourly with food for the first week, followed by 2 tablets (1000 mg) taken 12-hourly with food thereafter. (Participants that fail to tolerated the 1000 mg 12-hourly dose may revert back to the lower dose.)

DRUG

Sofosbuvir/Daclatasvir

Sofosbuvir/daclatasvir 400mg/60 mg sofosbuvir/daclatasvir fixed dose combination 1 tablet daily

Trial Locations (2)

2196

Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg

Unknown

Sunnyside Office Park, Johannesburg

All Listed Sponsors

lead

University of Witwatersrand, South Africa

OTHER