Comparison of Chemotherapy Before and After Surgery Versus After Surgery Alone for the Treatment of Gallbladder Cancer

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

186

Participants

Timeline

Start Date

February 24, 2021

Primary Completion Date

June 30, 2029

Study Completion Date

June 30, 2029

Conditions
Stage II Gallbladder Cancer AJCC v8Stage IIA Gallbladder Cancer AJCC v8Stage IIB Gallbladder Cancer AJCC v8Stage III Gallbladder Cancer AJCC v8Stage IIIA Gallbladder Cancer AJCC v8Stage IIIB Gallbladder Cancer AJCC v8
Interventions
DRUG

Cisplatin

Given IV

DRUG

Gemcitabine Hydrochloride

Given IV

PROCEDURE

Lymphadenectomy

Undergo portal lymphadenectomy

PROCEDURE

Partial Hepatectomy

Undergo partial hepatectomy

Trial Locations (367)

10065

Memorial Sloan Kettering Cancer Center, New York

10604

Memorial Sloan Kettering Westchester, East White Plains

11030

North Shore University Hospital, Manhasset

11040

Long Island Jewish Medical Center, New Hyde Park

11042

Northwell Health/Center for Advanced Medicine, Lake Success

11374

Queens Cancer Center, Rego Park

11501

NYU Langone Hospital - Long Island, Mineola

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

11794

Stony Brook University Medical Center, Stony Brook

12208

Albany Medical Center, Albany

14620

Highland Hospital, Rochester

14642

University of Rochester, Rochester

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

Thomas Jefferson University Hospital, Philadelphia

22031

Inova Schar Cancer Institute, Fairfax

22042

Inova Fairfax Hospital, Falls Church

25401

WVUH-Berkely Medical Center, Martinsburg

26101

Camden Clark Medical Center, Parkersburg

26330

United Hospital Center, Bridgeport

26506

West Virginia University Healthcare, Morgantown

27157

Wake Forest University Health Sciences, Winston-Salem

27518

Duke Cancer Institute Cary, Cary

27609

Duke Raleigh Hospital, Raleigh

27710

Duke University Medical Center, Durham

27834

East Carolina University, Greenville

29401

Roper Hospital, Charleston

29403

Charleston Oncology - Roper, Charleston

29414

Bon Secours Saint Francis Hospital, Charleston

Charleston Oncology - Saint Francis, Charleston

29425

Medical University of South Carolina, Charleston

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Emory Saint Joseph's Hospital, Atlanta

30501

Northeast Georgia Medical Center-Gainesville, Gainesville

30517

Northeast Georgia Medical Center Braselton, Braselton

31404

Low Country Cancer Care, Savannah

Memorial Health University Medical Center, Savannah

Summit Cancer Care-Memorial, Savannah

32610

University of Florida Health Science Center - Gainesville, Gainesville

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33905

Regional Cancer Center-Lee Memorial Health System, Fort Myers

35233

University of Alabama at Birmingham Cancer Center, Birmingham

37067

Vanderbilt-Ingram Cancer Center at Franklin, Franklin

Vanderbilt-Ingram Cancer Center Cool Springs, Franklin

37204

Vanderbilt Breast Center at One Hundred Oaks, Nashville

37232

Vanderbilt University/Ingram Cancer Center, Nashville

37920

University of Tennessee - Knoxville, Knoxville

38017

Baptist Memorial Hospital and Cancer Center-Collierville, Collierville

38120

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

38652

Baptist Memorial Hospital and Cancer Center-Union County, New Albany

38655

Baptist Memorial Hospital and Cancer Center-Oxford, Oxford

38671

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven

38901

Baptist Cancer Center-Grenada, Grenada

40004

Flaget Memorial Hospital, Bardstown

40165

Jewish Hospital Medical Center South, Shepherdsville

40202

Jewish Hospital, Louisville

The James Graham Brown Cancer Center at University of Louisville, Louisville

40215

Saints Mary and Elizabeth Hospital, Louisville

40245

UofL Health Medical Center Northeast, Louisville

40353

Saint Joseph Mount Sterling, Mount Sterling

40504

Saint Joseph Hospital, Lexington

Saint Joseph Radiation Oncology Resource Center, Lexington

40509

Saint Joseph Hospital East, Lexington

40536

University of Kentucky/Markey Cancer Center, Lexington

40701

Commonwealth Cancer Center-Corbin, Corbin

40741

Saint Joseph London, London

43210

Ohio State University Comprehensive Cancer Center, Columbus

44109

MetroHealth Medical Center, Cleveland

44484

Saint Joseph Warren Hospital, Warren

44501

Saint Elizabeth Youngstown Hospital, Youngstown

44512

Saint Elizabeth Boardman Hospital, Boardman

45005

Dayton Physicians LLC-Atrium, Franklin

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45236

Oncology Hematology Care Inc-Kenwood, Cincinnati

45242

Bethesda North Hospital, Cincinnati

45247

TriHealth Cancer Institute-Westside, Cincinnati

45255

TriHealth Cancer Institute-Anderson, Cincinnati

45331

Dayton Physicians LLC-Wayne, Greenville

Miami Valley Cancer Care and Infusion, Greenville

Wayne Hospital, Greenville

45373

Dayton Physicians LLC - Troy, Troy

Upper Valley Medical Center, Troy

45409

Miami Valley Hospital, Dayton

Premier Blood and Cancer Center, Dayton

Greater Dayton Cancer Center, Kettering

45415

Dayton Physician LLC - Englewood, Dayton

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45431

Indu and Raj Soin Medical Center, Beavercreek

45459

Dayton Physicians LLC-Miami Valley South, Centerville

Miami Valley Hospital South, Centerville

45504

Springfield Regional Cancer Center, Springfield

Springfield Regional Medical Center, Springfield

45840

Armes Family Cancer Center, Findlay

Blanchard Valley Hospital, Findlay

Orion Cancer Care, Findlay

47374

Reid Health, Richmond

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48116

University of Michigan - Brighton Center for Specialty Care, Brighton

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49009

Ascension Borgess Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49048

Borgess Medical Center, Kalamazoo

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49120

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49444

Trinity Health Muskegon Hospital, Muskegon

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

University of Michigan Health - West, Wyoming

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

50023

Mission Cancer and Blood - Ankeny, Ankeny

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

Mission Cancer and Blood - Des Moines, Des Moines

50314

Broadlawns Medical Center, Des Moines

Mercy Medical Center - Des Moines, Des Moines

Mission Cancer and Blood - Laurel, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50325

Mercy Cancer Center-West Lakes, Clive

Mission Cancer and Blood - West Des Moines, Clive

50501

Trinity Regional Medical Center, Fort Dodge

50801

Greater Regional Medical Center, Creston

51401

Saint Anthony Regional Hospital, Carroll

51503

Alegent Health Mercy Hospital, Council Bluffs

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

Marshfield Clinic-Minocqua Center, Minocqua

54601

Gundersen Lutheran Medical Center, La Crosse

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55905

Mayo Clinic in Rochester, Rochester

56187

Sanford Cancer Center Worthington, Worthington

56601

Sanford Joe Lueken Cancer Center, Bemidji

56701

Sanford Thief River Falls Medical Center, Thief River Falls

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58103

Sanford South University Medical Center, Fargo

Southpointe-Sanford Medical Center Fargo, Fargo

58104

Sanford Medical Center Fargo, Fargo

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59802

Saint Patrick Hospital - Community Hospital, Missoula

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60126

Elmhurst Memorial Hospital, Elmhurst

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

University of Chicago Medicine-Orland Park, Orland Park

60504

Rush - Copley Medical Center, Aurora

60540

Edward Hospital/Cancer Center, Naperville

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60560

Rush-Copley Healthcare Center, Yorkville

60585

Edward Hospital/Cancer Center?Plainfield, Plainfield

60611

Northwestern University, Chicago

60612

University of Illinois, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

OSF Saint Francis Radiation Oncology at Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62002

Saint Anthony's Health, Alton

62269

Cancer Care Center of O'Fallon, O'Fallon

HSHS Saint Elizabeth's Hospital, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Memorial Medical Center, Springfield

62801

Centralia Oncology Clinic, Centralia

Saint Mary's Hospital, Centralia

62864

Good Samaritan Regional Health Center, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63011

Saint Louis Cancer and Breast Institute-Ballwin, Ballwin

63080

Missouri Baptist Sullivan Hospital, Sullivan

63090

Mercy Hospital Washington, Washington

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63110

Washington University School of Medicine, St Louis

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63128

Mercy Hospital South, St Louis

63129

Siteman Cancer Center-South County, St Louis

63131

Missouri Baptist Medical Center, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

Southeast Cancer Center, Cape Girardeau

64506

Heartland Regional Medical Center, Saint Joseph

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65065

Lake Regional Hospital, Osage Beach

65109

MU Health Care Goldschmidt Cancer Center, Jefferson City

65401

Delbert Day Cancer Institute at PCRMC, Rolla

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

65613

Central Care Cancer Center - Bolivar, Bolivar

65616

Cox Cancer Center Branson, Branson

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

67530

Central Care Cancer Center - Great Bend, Great Bend

67846

Central Care Cancer Center - Garden City, Garden City

68046

Midlands Community Hospital, Papillion

68122

Alegent Health Immanuel Medical Center, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68131

Creighton University Medical Center, Omaha

68510

Saint Elizabeth Regional Medical Center, Lincoln

68803

Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island

68847

CHI Health Good Samaritan, Kearney

71913

CHI Saint Vincent Cancer Center Hot Springs, Hot Springs

72205

CARTI Cancer Center, Little Rock

University of Arkansas for Medical Sciences, Little Rock

72401

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro

72903

Mercy Hospital Fort Smith, Fort Smith

73120

Mercy Hospital Oklahoma City, Oklahoma City

75080

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75235

Parkland Memorial Hospital, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77802

Saint Joseph Regional Cancer Center, Bryan

78229

University of Texas Health Science Center at San Antonio, San Antonio

80122

Littleton Adventist Hospital, Littleton

80138

Parker Adventist Hospital, Parker

80210

Porter Adventist Hospital, Denver

80228

Saint Anthony Hospital, Lakewood

80501

Longmont United Hospital, Longmont

Rocky Mountain Cancer Centers-Longmont, Longmont

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

80923

Saint Francis Cancer Center, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81301

Mercy Medical Center, Durango

Southwest Oncology PC, Durango

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83686

Saint Luke's Cancer Institute - Nampa, Nampa

83712

Saint Luke's Cancer Institute - Boise, Boise

85004

Cancer Center at Saint Joseph's, Phoenix

87102

Lovelace Medical Center-Saint Joseph Square, Albuquerque

87106

University of New Mexico Cancer Center, Albuquerque

87110

Presbyterian Kaseman Hospital, Albuquerque

87124

Presbyterian Rust Medical Center/Jorgensen Cancer Center, Rio Rancho

90048

Cedars Sinai Medical Center, Los Angeles

90505

Torrance Memorial Physician Network - Cancer Care, Torrance

90509

Torrance Memorial Medical Center, Torrance

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

93401

Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo

93420

Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande

93444

Mission Hope Medical Oncology - Santa Maria, Santa Maria

94304

Stanford Cancer Institute Palo Alto, Palo Alto

94558

Providence Queen of The Valley, Napa

95403

Providence Medical Foundation - Santa Rosa, Santa Rosa

95405

Providence Santa Rosa Memorial Hospital, Santa Rosa

95608

Mercy Cancer Center - Carmichael, Carmichael

Mercy San Juan Medical Center, Carmichael

95695

Woodland Memorial Hospital, Woodland

95758

Mercy Cancer Center - Elk Grove, Elk Grove

95765

Mercy Cancer Center - Rocklin, Rocklin

95816

Mercy Cancer Center - Sacramento, Sacramento

95817

University of California Davis Comprehensive Cancer Center, Sacramento

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Cancer Institute Clackamas Clinic, Clackamas

97030

Legacy Mount Hood Medical Center, Gresham

97045

Providence Willamette Falls Medical Center, Oregon City

97062

Legacy Meridian Park Hospital, Tualatin

97132

Providence Newberg Medical Center, Newberg

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97239

Oregon Health and Science University, Portland

97420

Bay Area Hospital, Coos Bay

97701

Saint Charles Health System, Bend

97756

Saint Charles Health System-Redmond, Redmond

98003

Saint Francis Hospital, Federal Way

98022

Saint Elizabeth Hospital, Enumclaw

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98101

Virginia Mason Medical Center, Seattle

98104

Pacific Gynecology Specialists, Seattle

98107

Swedish Medical Center-Ballard Campus, Seattle

98122

Swedish Medical Center-First Hill, Seattle

98166

Highline Medical Center-Main Campus, Burien

98201

Providence Regional Cancer Partnership, Everett

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98284

PeaceHealth United General Medical Center, Sedro-Woolley

98310

Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton

98370

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo

98383

Saint Michael Cancer Center, Silverdale

98405

Franciscan Research Center-Northwest Medical Plaza, Tacoma

Northwest Medical Specialties PLLC, Tacoma

98499

Saint Clare Hospital, Lakewood

98503

Providence Regional Cancer System-Lacey, Lacey

98508

Anchorage Associates in Radiation Medicine, Anchorage

98520

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

Providence Regional Cancer System-Centralia, Centralia

98584

Providence Regional Cancer System-Shelton, Shelton

98597

Providence Regional Cancer System-Yelm, Yelm

98632

PeaceHealth Saint John Medical Center, Longview

98664

PeaceHealth Southwest Medical Center, Vancouver

98684

Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver

98686

Legacy Salmon Creek Hospital, Vancouver

99336

Kadlec Clinic Hematology and Oncology, Kennewick

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

99504

Anchorage Radiation Therapy Center, Anchorage

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

50266-7700

Methodist West Hospital, West Des Moines

01854

Lowell General Hospital, Lowell

01655

UMass Memorial Medical Center - University Campus, Worcester

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07207

Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus, Elizabeth

08690

The Cancer Institute of New Jersey Hamilton, Hamilton

07302

Jersey City Medical Center, Jersey City

08701

Monmouth Medical Center Southern Campus, Lakewood

07039

Saint Barnabas Medical Center, Livingston

07740

Monmouth Medical Center, Long Branch

07748

Memorial Sloan Kettering Monmouth, Middletown

07645

Memorial Sloan Kettering Bergen, Montvale

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

07101

Rutgers New Jersey Medical School, Newark

07112

Newark Beth Israel Medical Center, Newark

08876

Robert Wood Johnson University Hospital Somerset, Somerville

08755

Community Medical Center, Toms River

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

98122-5711

Swedish Medical Center-Cherry Hill, Seattle

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

ECOG-ACRIN Cancer Research Group

NETWORK