Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma

PHASE1RecruitingINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

September 20, 2020

Primary Completion Date

October 30, 2025

Study Completion Date

October 30, 2025

Conditions

GlioblastomaGliosarcoma

Interventions

DRUG

Peposertib

Given PO

RADIATION

Radiation Therapy

Undergo radiation therapy

PROCEDURE

Resection

Undergo surgical resection

DRUG

Temozolomide

Given PO

Trial Locations (1)

RECRUITING

M D Anderson Cancer Center, Houston

All Listed Sponsors

collaborator

National Cancer Institute (NCI)

NIH

lead

M.D. Anderson Cancer Center

OTHER