A Study of RO7293583 in Participants With Unresectable Metastatic Tyrosinase Related Protein 1 (TYRP1)-Positive Melanomas

PHASE1CompletedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

October 28, 2020

Primary Completion Date

July 28, 2022

Study Completion Date

July 28, 2022

Conditions
Cutaneous MelanomaUveal MelanomaMucosal Melanoma
Interventions
DRUG

RO7293583

RO7293583 will be administered at a dose and per schedule as specified for the respective cohort.

DRUG

Tocilizumab

Tocilizumab will be administered as required for the management of severe cytokine release syndrome (CRS).

DRUG

Obinutuzumab

If implemented, it will be given either on D-7 or D-7 and D-6.

DRUG

Adalimumab

If implemented, it will be given as a single dose approximately 6 days prior to the first dose of RO7293583.

Trial Locations (14)

2650

UZ Antwerpen, Edegem

2730

Herlev Hospital; Afdeling for Kræftbehandling, Herlev

3000

Peter Maccallum Cancer Institute; Clinical Trial Unit, Melbourne

UZ Leuven Gasthuisberg, Leuven

10065

Memorial Sloan-Kettering Cancer Center, New York

19107

Thomas Jefferson University Hospital;Medical Oncology, Philadelphia

28027

Clinica Universidad de Navarra Madrid; Servicio de Oncología, Madrid

31008

Clinica Universitaria de Navarra, Pamplona

37203

Sarah Cannon Research Institute, Nashville

46010

Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia, Valencia

02215

Dana Farber Cancer Institute, Boston

K1H 8L6

The Ottawa Hospital - General Campus, Ottawa

M5G 1Z5

Princess Margaret Cancer Center, Toronto

08035

Vall d´Hebron Institute of Oncology (VHIO), Barcelona, Barcelona

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT04551352 - A Study of RO7293583 in Participants With Unresectable Metastatic Tyrosinase Related Protein 1 (TYRP1)-Positive Melanomas | Biotech Hunter | Biotech Hunter