GLS4/RTV and TAF Drug-drug Interaction

PHASE1CompletedINTERVENTIONAL
Enrollment

28

Participants

Timeline

Start Date

January 10, 2021

Primary Completion Date

March 12, 2021

Study Completion Date

March 12, 2021

Conditions
Chronic Hepatitis B
Interventions
DRUG

GLS4

It is a new dihydropyrimidine antiviral drug that interferes the assembly of HBV core granule.

DRUG

RTV

"1. It is HIV protease inhibitors indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection;~2. It is a CYP3A inhibitor combined with other drug to increase the exposure in human."

DRUG

TAF

It is a hepatitis B virus (HBV) nucleoside analog reverse transcriptase inhibitor and is indicated for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease.

Trial Locations (1)

130000

The First Hospital of Jilin University, Changchun

All Listed Sponsors
lead

Sunshine Lake Pharma Co., Ltd.

INDUSTRY

NCT04551261 - GLS4/RTV and TAF Drug-drug Interaction | Biotech Hunter | Biotech Hunter