461
Participants
Start Date
December 17, 2020
Primary Completion Date
June 30, 2028
Study Completion Date
June 30, 2028
3-Dimensional Conformal Radiation Therapy
Undergo 3D-CRT
Biospecimen Collection
Undergo blood, urine and cerebrospinal fluid collection
Blinatumomab
Given IV
Bone Marrow Aspiration
Undergo bone marrow aspiration
Bone Marrow Biopsy
Undergo bone marrow biopsy
Calaspargase Pegol
Given IV
Cytarabine
Given IT
Dexamethasone
Given PO or IV
Hydrocortisone Sodium Succinate
Given IT
Lumbar Puncture
Undergo lumbar puncture
Mercaptopurine
Given PO
Methotrexate
Given IT, PO, and IV
Nivolumab
Given IV
Pegaspargase
Given IM or IV
Pegcrisantaspase
Given IM or IV
Vincristine Sulfate
Given IV push or via infusion
SUSPENDED
Sydney Children's Hospital, Randwick
SUSPENDED
The Children's Hospital at Westmead, Westmead
SUSPENDED
John Hunter Children's Hospital, Hunter Regional Mail Centre
SUSPENDED
Queensland Children's Hospital, South Brisbane
SUSPENDED
Perth Children's Hospital, Perth
RECRUITING
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
RECRUITING
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
RECRUITING
Montefiore Medical Center - Moses Campus, The Bronx
RECRUITING
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
RECRUITING
Maimonides Medical Center, Brooklyn
RECRUITING
NYU Langone Hospital - Long Island, Mineola
RECRUITING
Stony Brook University Medical Center, Stony Brook
RECRUITING
Albany Medical Center, Albany
RECRUITING
State University of New York Upstate Medical University, Syracuse
ACTIVE_NOT_RECRUITING
University of Rochester, Rochester
RECRUITING
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
RECRUITING
Geisinger Medical Center, Danville
RECRUITING
Lehigh Valley Hospital-Cedar Crest, Allentown
RECRUITING
Children's Hospital of Philadelphia, Philadelphia
RECRUITING
Saint Christopher's Hospital for Children, Philadelphia
RECRUITING
Alfred I duPont Hospital for Children, Wilmington
RECRUITING
Children's National Medical Center, Washington D.C.
RECRUITING
Sinai Hospital of Baltimore, Baltimore
RECRUITING
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
RECRUITING
Inova Fairfax Hospital, Falls Church
RECRUITING
Children's Hospital of The King's Daughters, Norfolk
SUSPENDED
WVUH-Berkely Medical Center, Martinsburg
SUSPENDED
Camden Clark Medical Center, Parkersburg
SUSPENDED
United Hospital Center, Bridgeport
SUSPENDED
West Virginia University Healthcare, Morgantown
RECRUITING
Wake Forest University Health Sciences, Winston-Salem
RECRUITING
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
RECRUITING
Duke University Medical Center, Durham
RECRUITING
East Carolina University, Greenville
RECRUITING
Carolinas Medical Center/Levine Cancer Institute, Charlotte
RECRUITING
Prisma Health Richland Hospital, Columbia
RECRUITING
BI-LO Charities Children's Cancer Center, Greenville
RECRUITING
Prisma Health Cancer Institute - Eastside, Greenville
RECRUITING
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
RECRUITING
Memorial Health University Medical Center, Savannah
RECRUITING
Nemours Children's Clinic-Jacksonville, Jacksonville
RECRUITING
Nemours Children's Clinic - Pensacola, Pensacola
SUSPENDED
Sacred Heart Hospital, Pensacola
RECRUITING
University of Florida Health Science Center - Gainesville, Gainesville
RECRUITING
AdventHealth Orlando, Orlando
RECRUITING
Arnold Palmer Hospital for Children, Orlando
RECRUITING
Nemours Children's Hospital, Orlando
RECRUITING
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
RECRUITING
Saint Mary's Medical Center, West Palm Beach
RECRUITING
Tampa General Hospital, Tampa
RECRUITING
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
RECRUITING
Johns Hopkins All Children's Hospital, St. Petersburg
RECRUITING
Golisano Children's Hospital of Southwest Florida, Fort Myers
RECRUITING
Children's Hospital of Alabama, Birmingham
RECRUITING
USA Health Strada Patient Care Center, Mobile
RECRUITING
The Children's Hospital at TriStar Centennial, Nashville
RECRUITING
Vanderbilt University/Ingram Cancer Center, Nashville
RECRUITING
East Tennessee Childrens Hospital, Knoxville
RECRUITING
University of Mississippi Medical Center, Jackson
RECRUITING
Norton Children's Hospital, Louisville
RECRUITING
University of Kentucky/Markey Cancer Center, Lexington
RECRUITING
Nationwide Children's Hospital, Columbus
SUSPENDED
ProMedica Flower Hospital, Sylvania
RECRUITING
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
RECRUITING
Rainbow Babies and Childrens Hospital, Cleveland
SUSPENDED
Cleveland Clinic Foundation, Cleveland
RECRUITING
Children's Hospital Medical Center of Akron, Akron
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
RECRUITING
Dayton Children's Hospital, Dayton
RECRUITING
Riley Hospital for Children, Indianapolis
RECRUITING
Corewell Health Children's, Royal Oak
SUSPENDED
Corewell Health William Beaumont University Hospital, Royal Oak
SUSPENDED
Corewell Health Beaumont Troy Hospital, Troy
RECRUITING
C S Mott Children's Hospital, Ann Arbor
SUSPENDED
Corewell Health Dearborn Hospital, Dearborn
RECRUITING
Children's Hospital of Michigan, Detroit
ACTIVE_NOT_RECRUITING
Michigan State University, East Lansing
SUSPENDED
Bronson Methodist Hospital, Kalamazoo
SUSPENDED
West Michigan Cancer Center, Kalamazoo
SUSPENDED
Bronson Battle Creek, Battle Creek
SUSPENDED
Beacon Kalamazoo, Kalamazoo
SUSPENDED
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph
SUSPENDED
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
SUSPENDED
Corewell Health Lakeland Hospitals - Niles Hospital, Niles
SUSPENDED
Trinity Health Muskegon Hospital, Muskegon
SUSPENDED
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores
SUSPENDED
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
RECRUITING
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
SUSPENDED
Trinity Health Grand Rapids Hospital, Grand Rapids
SUSPENDED
University of Michigan Health - West, Wyoming
SUSPENDED
Corewell Health Reed City Hospital, Reed City
SUSPENDED
Munson Medical Center, Traverse City
RECRUITING
Blank Children's Hospital, Des Moines
RECRUITING
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
RECRUITING
Children's Hospital of Wisconsin, Milwaukee
ACTIVE_NOT_RECRUITING
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
RECRUITING
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
RECRUITING
University of Minnesota/Masonic Cancer Center, Minneapolis
RECRUITING
Sanford Broadway Medical Center, Fargo
RECRUITING
Loyola University Medical Center, Maywood
RECRUITING
Lurie Children's Hospital-Chicago, Chicago
RECRUITING
University of Illinois, Chicago
RECRUITING
University of Chicago Comprehensive Cancer Center, Chicago
RECRUITING
Saint Jude Midwest Affiliate, Peoria
RECRUITING
Cardinal Glennon Children's Medical Center, St Louis
RECRUITING
Washington University School of Medicine, St Louis
RECRUITING
Mercy Hospital Saint Louis, St Louis
RECRUITING
Children's Mercy Hospitals and Clinics, Kansas City
RECRUITING
Children's Hospital and Medical Center of Omaha, Omaha
RECRUITING
University of Nebraska Medical Center, Omaha
RECRUITING
Children's Hospital New Orleans, New Orleans
ACTIVE_NOT_RECRUITING
Ochsner Medical Center Jefferson, New Orleans
RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
Medical City Dallas Hospital, Dallas
RECRUITING
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
RECRUITING
Cook Children's Medical Center, Fort Worth
RECRUITING
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
RECRUITING
M D Anderson Cancer Center, Houston
RECRUITING
Children's Hospital of San Antonio, San Antonio
RECRUITING
Methodist Children's Hospital of South Texas, San Antonio
RECRUITING
University of Texas Health Science Center at San Antonio, San Antonio
RECRUITING
Driscoll Children's Hospital, Corpus Christi
RECRUITING
Dell Children's Medical Center of Central Texas, Austin
RECRUITING
Covenant Children's Hospital, Lubbock
RECRUITING
UMC Cancer Center / UMC Health System, Lubbock
RECRUITING
El Paso Children's Hospital, El Paso
RECRUITING
Children's Hospital Colorado, Aurora
RECRUITING
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
RECRUITING
Saint Luke's Cancer Institute - Boise, Boise
RECRUITING
Primary Children's Hospital, Salt Lake City
RECRUITING
Phoenix Childrens Hospital, Phoenix
RECRUITING
Banner Children's at Desert, Mesa
RECRUITING
Banner University Medical Center - Tucson, Tucson
SUSPENDED
Kingman Regional Medical Center, Kingman
SUSPENDED
Hope Cancer Care of Nevada-Pahrump, Pahrump
SUSPENDED
Comprehensive Cancer Centers of Nevada - Henderson, Henderson
SUSPENDED
Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson
SUSPENDED
Las Vegas Cancer Center-Henderson, Henderson
SUSPENDED
OptumCare Cancer Care at Seven Hills, Henderson
SUSPENDED
Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson
SUSPENDED
OptumCare Cancer Care at Charleston, Las Vegas
SUSPENDED
Hope Cancer Care of Nevada, Las Vegas
SUSPENDED
Sunrise Hospital and Medical Center, Las Vegas
SUSPENDED
Ann M Wierman MD LTD, Las Vegas
SUSPENDED
Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas
SUSPENDED
OptumCare Cancer Care at MountainView, Las Vegas
RECRUITING
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
SUSPENDED
Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas
SUSPENDED
Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas
RECRUITING
Summerlin Hospital Medical Center, Las Vegas
SUSPENDED
Comprehensive Cancer Centers of Nevada, Las Vegas
SUSPENDED
OptumCare Cancer Care at Fort Apache, Las Vegas
SUSPENDED
Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas
RECRUITING
Renown Regional Medical Center, Reno
SUSPENDED
Saint Mary's Regional Medical Center, Reno
SUSPENDED
Cancer Care Specialists - Reno, Reno
SUSPENDED
Carson Tahoe Regional Medical Center, Carson City
RECRUITING
Children's Hospital Los Angeles, Los Angeles
SUSPENDED
Kaiser Permanente Los Angeles Medical Center, Los Angeles
RECRUITING
Cedars Sinai Medical Center, Los Angeles
RECRUITING
Mattel Children's Hospital UCLA, Los Angeles
RECRUITING
Kaiser Permanente Downey Medical Center, Downey
ACTIVE_NOT_RECRUITING
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance
SUSPENDED
Kaiser Permanente-Bellflower, Bellflower
ACTIVE_NOT_RECRUITING
City of Hope Comprehensive Cancer Center, Duarte
RECRUITING
Kaiser Permanente-San Diego Zion, San Diego
RECRUITING
Rady Children's Hospital - San Diego, San Diego
RECRUITING
Kaiser Permanente-Fontana, Fontana
RECRUITING
Loma Linda University Medical Center, Loma Linda
RECRUITING
Kaiser Permanente-Anaheim, Anaheim
RECRUITING
Children's Hospital of Orange County, Orange
SUSPENDED
PCR Oncology, Arroyo Grande
RECRUITING
Valley Children's Hospital, Madera
RECRUITING
UCSF Medical Center-Mission Bay, San Francisco
RECRUITING
Lucile Packard Children's Hospital Stanford University, Palo Alto
RECRUITING
Kaiser Permanente-Oakland, Oakland
RECRUITING
Sutter Medical Center Sacramento, Sacramento
RECRUITING
University of California Davis Comprehensive Cancer Center, Sacramento
RECRUITING
Kapiolani Medical Center for Women and Children, Honolulu
RECRUITING
Legacy Emanuel Children's Hospital, Portland
RECRUITING
Oregon Health and Science University, Portland
SUSPENDED
Overlake Medical Center, Bellevue
SUSPENDED
Valley Medical Center, Renton
RECRUITING
Seattle Children's Hospital, Seattle
RECRUITING
Mary Bridge Children's Hospital and Health Center, Tacoma
RECRUITING
Madigan Army Medical Center, Tacoma
SUSPENDED
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima
RECRUITING
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
SUSPENDED
Providence Alaska Medical Center, Anchorage
RECRUITING
Arkansas Children's Hospital, Little Rock
RECRUITING
Connecticut Children's Medical Center, Hartford
RECRUITING
Yale University, New Haven
RECRUITING
Maine Children's Cancer Program, Scarborough
ACTIVE_NOT_RECRUITING
Walter Reed National Military Medical Center, Bethesda
ACTIVE_NOT_RECRUITING
Tufts Children's Hospital, Boston
SUSPENDED
Las Vegas Cancer Center-Medical Center, Las Vegas
RECRUITING
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
RECRUITING
Hackensack University Medical Center, Hackensack
RECRUITING
Morristown Medical Center, Morristown
RECRUITING
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
RECRUITING
Rutgers Cancer Institute of New Jersey, New Brunswick
RECRUITING
Newark Beth Israel Medical Center, Newark
RECRUITING
Saint Joseph's Regional Medical Center, Paterson
RECRUITING
Rhode Island Hospital, Providence
RECRUITING
Sanford USD Medical Center - Sioux Falls, Sioux Falls
RECRUITING
University of Vermont and State Agricultural College, Burlington
SUSPENDED
CancerCare Manitoba, Winnipeg
SUSPENDED
Janeway Child Health Centre, St. John's
SUSPENDED
IWK Health Centre, Halifax
RECRUITING
The Montreal Children's Hospital of the MUHC, Montreal
RECRUITING
Centre Hospitalier Universitaire Sainte-Justine, Montreal
RECRUITING
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke
RECRUITING
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec
RECRUITING
University Pediatric Hospital, San Juan
National Cancer Institute (NCI)
NIH