A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

760

Participants

Timeline

Start Date

September 28, 2020

Primary Completion Date

March 31, 2027

Study Completion Date

March 31, 2027

Conditions
Esophageal Squamous Cell Carcinoma
Interventions
DRUG

Tiragolumab

Tiragolumab at a fixed dose of 600 milligrams (mg) administered by intravenous (IV) infusion every 3 weeks (Q3W) on Day 1 of each 21-day cycle.

DRUG

Atezolizumab

Atezolizumab at a fixed dose of 1200 mg administered by IV infusion Q3W on Day 1 of each 21-day cycle.

DRUG

Tiragolumab Matching Placebo

Tiragolumab matching placebo administered by IV infusion Q3W on Day 1 of each 21-day cycle.

DRUG

Atezolizumab Matching Placebo

Atezolizumab matching placebo administered by IV infusion Q3W on Day 1 of each 21-day cycle.

Trial Locations (165)

100

National Taiwan University Hospital, Taipei

404

China Medical University Hospital, Taichung

710

Chi-Mei Medical Centre, Tainan City

1090

AKH - Medizinische Universität Wien, Vienna

2650

UZ Antwerpen, Edegem

3000

UZ Leuven Gasthuisberg, Leuven

3010

Inselspital Bern, Insel-Gruppe AG, Bern

3084

Austin Health, Heidelberg

3112

Tauranga Hospital, Clinical Trials Unit, Tauranga

4000

CHU de Liège (Sart Tilman), Liège

4010

Ordensklinikum Linz Barmherzige Schwestern, Linz

4102

Princess Alexandra Hospital, Woolloongabba

6008

St John of God Hospital, Subiaco

6020

Tiroler Landeskrankenanstalten Ges.M.B.H., Innsbruck

6045

Cancercare, Port Elizabeth

6720

Szegedi Tudományegyetem, Szeged

7623

Pécsi Tudományegyetem, Pécs

8091

UniversitätsSpital Zürich, Zurich

9020

Klinikum Klagenfurt am Wörthersee, Klagenfurt

10100

Institut National D'oncologie Sidi Med Benabdellah, Rabat

10300

Vajira Hospital, Bangkok

10330

Chulalongkorn Hospital, Bangkok

10400

Ramathibodi Hospital, Bangkok

10700

Siriraj Hospital, Bangkok

13385

Hopital Timone Adultes, Marseille

14004

Hospital Universitario Reina Sofia, Córdoba

14221

Great Lakes Cancer Center, Williamsville

15006

Complejo Hospitalario Universitario A Coruña (CHUAC), A Coruña

16499

Ajou University Medical Center, Gyeonggi-do

21000

CHU Dijon Bourgogne Hôpital François Mitterand, Dijon

21029

Vinnytsya Regional Clinical Oncology Dispensary, Vinnytsia

25240

Ataturk University Medical Faculty Yakutiye Research Hospital Medical Oncology Department, Erzurum

28040

Fundacion Jimenez Diaz, Madrid

29010

Hospital Regional Universitario Carlos Haya, Málaga

29609

CHRU De Brest - Hopital Morvan - Institut De Cancerologie Et D'Hematologie, Brest

30000

Centre Hospitalier Universitaire Hassan II, Fes

30100

International Cancer Institute (ICI), Eldoret

31059

Hopital Rangueil, Toulouse

33006

Hospital Univ. Central de Asturias, Oviedo

33100

Asu Fc S. M. Della Misericordia, Udine

33604

Hopital Du Haut-Leveque, Pessac

33901

Florida Cancer Specialists - Fort Myers (Broadway), Fort Myers

35032

Klinikum der Philipps-Universität Marburg, Marburg

35128

Istituto Oncologico Veneto IRCCS, Padua

37075

Klinik für Gastroenterologie und Gastrointestinale Onkologie der UMG, Göttingen

39120

Med. Fak. d. Otto-von-Guericke-Universität, Magdeburg

40000

Centre Hospitalier Universitaire Mohamed VI, Marrakesh

40005

RCI Sumy Regional Clinical Oncological Dispensary, Sumy

41404

Kyungpook National University Chilgok Hospital, Daegu

44280

Inonu University Faculty of Medicine Turgut Ozal Medical Center, Malatya

45122

Universitätsklinikum Essen Klinik f.Strahlentherapie, Essen

45136

Kliniken Essen-Mitte, Evang. Huyssens-Stiftung, Klinik für Internistische Onkologie / Haematologie, Essen

46010

Hospital Clinico Universitario de Valencia, Valencia

48018

Ospedale Degli Infermi - Faenza, Faenza

58128

Chonnam National University Hwasun Hospital, Jeollanam-do

59037

Hopital Claude Huriez, Lille

61070

Municipal Noncommercial Institution Regional Center of Oncology, Kharkiv

69373

Centre Leon Berard, Lyon

75908

European Hospital Georges Pompidou (HEGP), Paris

80131

Università degli Studi della Campania Luigi Vanvitelli, Napoli

86021

Chu La Miletrie, Poitiers

90110

Songklanagarind Hospital, Songkhla

93053

Universitätsklinikum Klinik u.Poliklinik f.Strahlentherapie, Regensburg

100021

Cancer Hospital Chinese Academy of Medical Sciences., Beijing

110042

Liaoning cancer Hospital & Institute, Shenyang

112201

Taipei Veterans General Hospital, Taipei

115478

Russian Oncology Research Center n.a. N.N. Blokhin Dpt of Clinical Pharmacology and Chemotherapy, Moscow

200000

Shanghai Chest Hospital, Shanghai

200032

Fudan University Shanghai Cancer Center, Shanghai

210008

Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing

213000

Changzhou Cancer hospital, Changzhou

221000

The Affiliated Hospital of Xuzhou Medical College, Xuzhou

222002

The First People's Hospital of Lian Yun Gang, Lianyungang

225001

Subei People's Hospital of Jiangsu province, Yangzhou

233004

Affiliated Hospital of Bengbu Medical College, Bengbu

250117

Shandong Cancer Hospital, Jinan

272029

Affiliated Hospital of Jining Medical University, Jining

300060

Tianjin Cancer Hospital, Tianjin

310022

Zhejiang Cancer Hospital, Hangzhou

350014

Fujian Cancer Hospital, Fuzhou

361003

The First Affiliated Hospital of Xiamen University, Xiamen

361004

Zhongshan Hospital Xiamen University, Xiamen

400030

Chongqing Cancer Hospital, Chongqing

404000

Chongqing Sanxia Central Hospital, Chongqing

410013

Hunan Cancer Hospital, Changsha

420029

Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic, Kazan'

426067

City Oncological Hospital, Izhevsk

430022

Wuhan Union Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan

430079

Hubei Cancer Hospital, Wuhan

455000

Anyang Tumor Hosptial, Anyang

471003

The First Affiliated Hospital to Henan University of Science and Technology, Luoyang

510060

Sun Yet-sen University Cancer Center, Guangzhou

510515

Nanfang Hospital, Southern Medical University, Guangzhou

515041

Cancer Hospital of Shantou University Medical College, Shantou

610041

Sichuan Provincial Cancer Hospital, Chengdu

West China Hospital, Sichuan University, Chengdu

630005

"Limited Liability Company RC Medical", Novosibirsk

634063

Regional Oncology Dispensary, Tomsk

660133

Krasnoyarsk Regional Oncology Dispensary n.a. Krizhanovsky, Krasnoyarsk

3525408

Rambam Health Corporation, Rambam

6423906

Tel Aviv Sourasky Medical Ctr, Tel Aviv

9112000

Hadassah Ein Karem Hospital, Jerusalem

67214-3728

Cancer Center of Kansas, Wichita

C1012AAR

Instituto de Investigaciones Metabolicas (Idim), Buenos Aires

C1093AAS

Fundacion Favaloro, Buenos Aires

F5300COE

Centro Oncologico Riojano Integral (CORI), La Rioja

046000

Heping Hospital Affiliated to Changzhi Medical College, Changzhi

Unknown

Jieyang People's Hospital, Jieyang

Lishui Central Hospital, Lishui

Cancer Hospital Chinese Academy of Medical Sciences Shenzhen Center, Shenzhen

The First Affiliated Hospital of Xinxiang Medical University, Xinxiang

Limpopo Cancer Research Institute, Polokwane

Eugene Marais Hospital, Pretoria

Hospital La Fe, Valencia

Chang Gung Medical Foundation - Kaohsiung;Oncology, Kaohisung

Van Yuzuncu Yil University Hospital, Van

Zhytomyr Regional Oncology Center, Zhytomyr

050035

Hebei Medical University Fourth Hospital, Shijiazhuang

06189

Centre Antoine Lacassagne, Nice

04103

Universitaetsklinikum Leipzig, Leipzig

115 28

"Evgenidio Hospital Agia Trias", Athens

711 10

Univ General Hosp Heraklion, Heraklion

546 45

Euromedical General Clinic of Thessaloniki, Thessaloniki

464-8681

Aichi Cancer Center Hospital, Aichi

277-8577

National Cancer Center Hospital East, Chiba

734-8551

Hiroshima University Hospital, Hiroshima

650-0017

Kobe University Hospital, Hyōgo

232-0024

Yokohama City University Medical Center, Kanagawa

241-8515

Kanagawa Cancer Center, Kanagawa

980-8574

Tohoku University Hospital, Miyagi

951-8566

Niigata Cancer Center Hospital, Niigata

541-8567

Osaka International Cancer Institute, Osaka

565-0871

The University of Osaka Hospital, Osaka

350-1298

Saitama Medical University International Medical Center, Saitama

362-0806

Saitama Cancer Center, Saitama

411-8777

Shizuoka Cancer Center, Shizuoka

135-8550

The Cancer Institute Hospital of JFCR, Tokyo

160-8582

Keio University Hospital, Tokyo

00100

Aga Khan University Hospital, Nairobi

85-796

Centrum Onkologii, Bydgoszcz

20-090

Centrum Onkologii Ziemi Lubelskiej Im. ?W. Jana Z Dukli, Lublin

10-228

Szpital Kliniczny MSWiA z Warmi?sko-Mazurskim Centrum Onkologii, Olsztyn

61-866

Wielkopolskie Centrum Onkologii im. Marii Sk?odowskiej-Curie, Późna

02-034

NIO im Marii Sklodowskiej-Curie, Warsaw

53-413

Dolno?l?skie Centrum Onkologii, Wroc?aw

3000-075

HUC, Coimbra

4099-001

Centro Hospitalar do Porto ? Hospital de Santo António, Porto

4200-072

IPO do Porto, Porto

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08308

Korea University Guro Hospital, Seoul

08035

Hospital Universitari Vall d'Hebron, Barcelona

08036

Hospital Clinic I Provincial, Barcelona

00704

National Cheng Kung University Hospital, Tainan City

01250

Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital, Adana

06700

Ankara University Faculty of Medicine Cebeci Hospital, Ankara

06800

Ankara City Hospital, Ankara

BH7 7DW

Royal Bournemouth Hospital, Bournemouth

CB2 0QQ

Addenbrookes Hospital, Cambridge

DD1 9SY

Ninewells Hospital, London

SW3 6JJ

Royal Marsden Hospital - Fulham, London

CH63 4JY

Clatterbridge Cancer Centre, Metropolitan Borough of Wirral

SM2 5PT

Royal Marsden Hospital (Sutton), Sutton

WV10 0QP

New Cross Hospital, Wolverhampton

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY