The Study of KN046 in Combination With Lenvatinib in Advanced Hepatocellular Carcinoma

PHASE2CompletedINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

September 11, 2020

Primary Completion Date

February 23, 2022

Study Completion Date

March 15, 2024

Conditions
HCC
Interventions
BIOLOGICAL

KN046

Subjects enrolled in the study will be intravenously administered KN046 5mg/kg every 3 weeks (Q3W), until disease progression, or unacceptable toxicity, or withdrawal of consent, or lost to follow-up, or died, or treatment for 2 years, or the investigator decides to terminate.

DRUG

Lenvatinib

Subjects enrolled in the study will receive lenvatinib 12 mg (BW≥60 kg) or 8 mg (BW\<60 kg) orally once a day (QD) ,until disease progression, or unacceptable toxicity, or withdrawal of consent, or lost to follow-up, or died, or treatment for 2 years, or the investigator decides to terminate.

Trial Locations (2)

100000

Beijing Cancer Hospital, Beijing

150000

Harbin Medical University Cancer Hospital, Harbin

All Listed Sponsors
lead

Peking University Cancer Hospital & Institute

OTHER

NCT04542837 - The Study of KN046 in Combination With Lenvatinib in Advanced Hepatocellular Carcinoma | Biotech Hunter | Biotech Hunter