A Study of Tucatinib Plus Trastuzumab Deruxtecan in HER2+ Breast Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

December 1, 2020

Primary Completion Date

July 15, 2024

Study Completion Date

March 7, 2025

Conditions
HER2 Positive Breast Cancer
Interventions
DRUG

tucatinib

300 mg orally twice daily

DRUG

trastuzumab deruxtecan

5.4 mg/kg via intravenous (into the vein; IV) infusion on Day 1 of each of 21-day cycle

Trial Locations (140)

10065

Evelyn H. Lauder Breast and Imaging Center (BAIC)., New York

10604

MSK Westchester, Harrison

11101

Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy, Long Island City

11553

MSK Nassau, Uniondale

11725

MSK Commack, Commack

15102

UPMC Hillman Cancer Center Upper Saint Clair, Pittsburgh

15146

UPMC Hillman Cancer Center UPMC East, Monroeville

15213

Magee-Womens Hospital of UPMC, Pittsburgh

15232

University of Pittsburgh Cancer Institute Investigational Drug Service UPMC Hillman Cancer Center, Pittsburgh

UPMC Cancer Centers William M. Cooper Ambulatory Care Pavilion of the Hillman Cancer Center, Pittsburgh

15237

UPMC Hillman Cancer Center UPMC Passavant, Pittsburgh

15301

UPMC Hillman Cancer Center Washington, Washington

15401

UPMC Hillman Cancer Center Uniontown, Uniontown

15601

UPMC Hillman Cancer Center Mountainview, Greensburg

16066

UPMC Hillman Cancer Center Passavant North, Cranberry Township

16505

UPMC Hillman Cancer Center Erie, Erie

20007

Georgetown University Medical Center, Washington D.C.

20010

Washington Cancer Institute at MedStar Washington Hospital Center, Washington D.C.

20155

Virginia Cancer Specialists, PC, Gainesville

20176

Virginia Cancer Specialists, PC, Leesburg

20190

Virginia Cancer Specialists, PC, Reston

21237

Harry and Jeanette Weinberg Cancer Institute at Franklin Square, Baltimore

22031

Virginia Cancer Specialists, PC, Fairfax

24014

Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care, Roanoke

24060

Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care, Blacksburg

24153

Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care, Salem

24382

Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care, Wytheville

24457

Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care, Low Moor

30033

Northside Hospital, Inc. - GCS/Decatur, Decatur

30041

Atlanta Cancer Care - Cumming, Cumming

30046

NHCI Suburban Hematology-oncology Associates - lawrenceville, Lawrenceville

30060

Northside Hospital, Inc. - GCS/Marietta, Marietta

30096

NHCI Suburban Hematology-oncology Associates - Duluth, Duluth

30114

Northside Hospital, Inc - GCS/Canton, Canton

30281

Atlanta Cancer Care - Stockbridge, Stockbridge

30308

Winship Cancer Institute @ Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital, Atlanta

The Emory Clinic, Atlanta

Winship Cancer Institute / Emory University School of Medicine, Atlanta

Winship Cancer Institute, Atlanta

30342

Atlanta Cancer Care - Atlanta, Atlanta

Northside Hospital, Inc. - Central Research Department, Atlanta

Northside Hospital, Inc. - GCS/Center Pointe, Atlanta

30512

Northside Hospital, Inc - GCS/Blairsville, Blairsville

30606

Northside Hospital, Inc - GCS/Athens, Athens

31217

Northside Hospital, Inc - GCS/Macon, Macon

32159

Florida Cancer Specialists, The Villages

32605

Florida Cancer Specialists, Gainesville

32701

Florida Cancer Specialists, Altamonte Springs

32763

Florida Cancer Specialists, Orange City

32778

Florida Cancer Specialists, Tavares

32789

Florida Cancer Specialists, Winter Park

32806

Florida Cancer Specialists, Orlando

33511

Florida Cancer Specialists, Brandon

33607

Florida Cancer Specialists, Tampa

33705

Florida Cancer Specialists, St. Petersburg

33761

Florida Cancer Specialists, Clearwater

33770

Florida Cancer Specialists, Largo

34461

Florida Cancer Specialists, Lecanto

34474

Florida Cancer Specialists, Ocala

34655

Florida Cancer Specialists, Trinity

35233

University Of Alabama at Birmingham, Birmingham

35249

University of Alabama at Birmingham, IDS Pharmacy, Birmingham

University Of Alabama at Birmingham, Birmingham

37055

Tennessee Oncology, PLLC, Dickson

37066

Tennessee Oncology, PLLC, Gallatin

37067

Tennessee Oncology, PLLC, Franklin

37075

Tennessee Oncology, PLLC, Hendersonville

37076

Tennessee Oncology, PLLC, Hermitage

37129

Tennessee Oncology, PLLC, Murfreesboro

37160

Tennessee Oncology, PLLC, Shelbyville

37167

Tennessee Oncology, PLLC, Smyrna

37203

Tennessee Oncology, PLLC, Nashville

The Sarah Cannon Research Institute, Nashville

37205

Tennessee Oncology, PLLC, Nashville

37207

Tennessee Oncology, PLLC, Nashville

37211

Tennessee Oncology, PLLC, Nashville

37311

Tennessee Oncology, PLLC, Cleveland

37403

Tennessee Oncology, PLLC, Chattanooga

37404

Sarah Cannon Research Institute, Chattanooga

Tennessee Oncology, PLLC, Chattanooga

37909

Tennessee Oncology, PLLC, Lebanon

53715

UW Health Oncology - One South Park, Madison

53792

University of Wisconsin Clinical Science Center, Madison

55102

Allina Health Cancer Institute, Saint Paul

Minnesota Oncology Hematology PA, Saint Paul

Minnesota Oncology Hematology, PA, Saint Paul

United Hospital, Saint Paul

55404

Minnesota Oncology Hematology, PA, Minneapolis

55407

Abbott Northwestern Hospital, Minneapolis

Allina Health Cancer institute, Minneapolis

55432

Mercy Hospital - Unity Campus, Fridley

55433

Mercy Hospital, Coon Rapids

Minnesota Oncology Hematology, PA, Coon Rapids

Minnesota Oncology Hematology, PA, Fridley

55905

Mayo Clinic, Rochester

68046

Oncology Hematology West, PC dba Nebraska Cancer Specialists, Papillion

68114

Oncology Hematology West, PC dba Nebraska Cancer Specialists, Omaha

68124

Oncology Hematology West, PC dba Nebraska Cancer Specialists, Omaha

68130

Oncology Hematology West, PC dba Nebraska Cancer Specialists, Omaha

75063

US Oncology Investigational Product Center (IPC), Irving

US Oncology Investigational Products Center (IPC), Irving

US Oncology lnvestigational Products Center (IPC), Irving

77030

The University of Texas M.D. Anderson Cancer Center, Houston

U.T. MD Anderson Cancer Center, Houston

80045

University of Colorado Denver CTO/CTRC - Outpatient., Aurora

University of Colorado Hospital - Anschutz Cancer Pavilion (ACP), Aurora

University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP), Aurora

University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP), Aurora

80124

UC Health Lone Tree Medical Center, Lone Tree

85704

Arizona Oncology Associates, PC - HOPE, Tucson

85711

Arizona Oncology Associates, PC - HOPE, Tucson

90095

(IRB# 20-001502) Ronald Reagan UCLA Medical Center, Drug Information Center, Los Angeles

UCLA Hematology/Oncology, Los Angeles

90404

UCLA Hematology/Oncology - Santa Monica, Santa Monica

UCLA Hematology/Oncology Parkside, Santa Monica

91010

City of Hope (City of Hope National Medical Center, City of Hope Medical center), Duarte

City of Hope Investigational Drug Services (IDS), Duarte

91105

UCLA Hematology/Oncology - Pasadena, Pasadena

91361

UCLA Hematology/Oncology - Westlake, Westlake Village

91505

UCLA Hematology/Oncology - Burbank, Burbank

91801

UCLA Hematology/Oncology - Alhambra, Alhambra

92653

UCLA Hematology/Oncology - Laguna Hills, Laguna Hills

93003

UCLA Hematology/Oncology - Ventura, Ventura

93105

UCLA Hematology/Oncology - Santa Barbara, Santa Barbara

93401

UCLA Hematology/Oncology - San Luis Obispo, San Luis Obispo

94110

Zuckerberg San Francisco General Hospital- Breast Clinic, San Francisco

Zuckerberg San Francisco General Hospital- Oncology Clinic, San Francisco

94158

University of California, San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center, San Francisco

97213

Providence Cancer Institute Franz Clinic, Portland

Providence Portland Medical Center, Portland

98109

Fred Hutchinson Cancer Center, Seattle

98195

University of Washington Medical Center, Seattle

02115

Brigham and Women's Hospital, Boston

02215

Dana-Farber Cancer Institute, Boston

02459

Dana Farber Cancer Institute- Chestnut Hill, Newton

07920

MSK Basking Ridge, Basking Ridge

07601

Hackensack University Medical Center, Hackensack

07748

MSK Monmouth, Middletown

07645

MSK Bergen, Montvale

All Listed Sponsors
lead

Seagen, a wholly owned subsidiary of Pfizer

INDUSTRY

NCT04539938 - A Study of Tucatinib Plus Trastuzumab Deruxtecan in HER2+ Breast Cancer | Biotech Hunter | Biotech Hunter