Opioid-free Analgesia for the Management of Acute Post-operative Pain Following Caesarean Section

NACompletedINTERVENTIONAL
Enrollment

324

Participants

Timeline

Start Date

November 4, 2020

Primary Completion Date

March 30, 2021

Study Completion Date

March 31, 2021

Conditions
Acute Post-operative Pain Following Caesarean Section
Interventions
DRUG

Magnesium sulphate

"1g of paracetamol as an I.V infusion and 4g of magnesium sulphate as an I.V. bolus preoperatively. Continuous infusion of 1g/hr of magnesium sulphate intraoperatively and for the first 2 hours post-operatively. Further post-operatively, 100 mg of suppository diclofenac 12 hourly, intravenous paracetamol 1g 6 hourly, both over 24 hours.~N.B: Intramuscular pentazocine 30 mg (45 mg if patient is \> 70 kg) will be used as rescue analgesia as needed (that is, only on patients' request for further analgesia or following an assessment of moderate to severe pain despite the planned analgesic regimen) at least 4 hourly during the first 24 hours after caesarean section."

DRUG

Pentazocine

"Post-operatively, suppository diclofenac 100mg 12 hourly, intramuscular pentazocine 30 mg (45 mg if patient is \> 70 kg) 6 hourly, intravenous paracetamol 1g 6 hourly, all for 24 hours.~N.B: Intramuscular pentazocine 30 mg (45 mg if patient is \> 70 kg) will be used as rescue analgesia as needed (that is, only on patients' request for further analgesia or following an assessment of moderate to severe pain despite the planned analgesic regimen) at least 4 hourly during the first 24 hours after caesarean section."

Trial Locations (1)

560231

Federal Medical Centre, Yenagoa, Yenagoa

All Listed Sponsors
lead

Olakunle Ifeoluwa Makinde

OTHER_GOV

NCT04539249 - Opioid-free Analgesia for the Management of Acute Post-operative Pain Following Caesarean Section | Biotech Hunter | Biotech Hunter