308
Participants
Start Date
October 13, 2020
Primary Completion Date
May 3, 2023
Study Completion Date
January 31, 2026
Amivantamab
Amivantamab will be administered as an IV infusion at a dose of 1400 mg (1750 mg if body weight is \>=80 kilogram \[kg\]) by once weekly up to Cycle 2 Day 1, then 1750 mg (2100 mg if body weight is \>=80 kg) on Day 1 of each 21-day cycle, starting with Cycle 3 and will continue the same treatment in OLE phase then in LTE phase.
Pemetrexed
Pemetrexed will be administered as 500 mg/m\^2 IV infusion (with vitamin supplementation) on Day 1 of each 21-day cycle and then as maintenance monotherapy until disease progression in Arm A and will continue the same treatment in OLE phase then in LTE phase.
Carboplatin
Carboplatin will be administered as AUC 5 IV infusion for up to 4 cycles on Day 1 of each 21-day cycle.
Pemetrexed
Pemetrexed will be administered as 500 mg/m\^2 IV infusion (with vitamin supplementation) on Day 1 of each 21-day cycle and then as maintenance monotherapy until disease progression in Arm B and will continue the same treatment in OLE phase then in LTE phase.
Chung Shan Medical University Hospital, Taichung
Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung City
Chang Gung Medical Foundation, Kaohsiung City
Tudogyogyintezet Torokbalint, Törökbálint
Chris O'Brien Lifehouse, Camperdown
St George Hospital, Kogarah
UZ Leuven, Leuven
Cabrini Medical Centre, Malvern
Mátrai Gyógyintézet-Bronchológia, Gyöngyös
CHU UCL Namur - Site Godinne, Yvoir
Sir Charles Gairdner Hospital, Nedlands
Gazi University Hospital, Ankara
Ankara Bilkent City Hospital, Ankara
Fejer Varmegyei Szent Gyorgy Egyetemi Oktatokorhaz, Székesfehérvár
Algemeen Ziekenhuis Delta, Roeselare
Markusovszky Egyetemi Oktatokorhaz, Szombathely
National Taiwan University Hospital, Taipei
Langone Health at NYC University, NYU School of Medicine, New York
Columbia University Medical Center, New York
Phramongkutklao Hospital and Medical College, Bangkok
National Cancer Center, Gyeonggi-do
Siriraj Hospital, Bangkok
Hospital Pulau Pinang, George Town
Evangelische Lungenklinik Berlin, Berlin
Seoul National University Bundang Hospital, Seongnam-si
Médica Sur, Mexico City
Instituto Nacional de Cancerologia, Mexico City
Hosp Univ A Coruna, A Coruña
Georgetown University Hospital, Washington D.C.
San Gerardo Hospital, Monza
Istituto Clinico Humanitas, Rozzano
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan
IRCCS Ospedale San Raffaele, Milan
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Centre Georges Francois Leclerc, Dijon
Trakya University Medical Faculty, Edirne
Virginia Cancer Specialists, Fairfax
Taipei Medical University Shuang Ho Hospital, New Taipei City
Blue Ridge Cancer Care, Salem
Pius-Hospital Oldenburg, Oldenburg
Hosp. Gral. Univ. Gregorio Maranon, Madrid
Hosp. Univ. Ramon Y Cajal, Madrid
Hosp. Univ. 12 de Octubre, Madrid
Hosp. Univ. La Paz, Madrid
Hosp. Univ. Pta. de Hierro Majadahonda, Majadahonda
Hosp Virgen de La Victoria, Málaga
University Cancer And Blood Center LLC, Athens
Clinica Univ. de Navarra, Pamplona
Centro Oncologico de Chihuahua, Chihuahua City
Institut Bergonie, Bordeaux
CHU Bordeaux, Pessac
H. Lee Moffitt Cancer & Research Institute, Tampa
Istanbul Universitesi Cerrahpasa Tip Fakultesi Ic Hastaliklari Anabilim Dali Medikal Onkoloji Bd, Istanbul
Medipol Mega University Hospital, Istanbul
Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi, Istanbul
Izmir Medical Park Hospital, Izmir
A O U Sant Orsola Malpighi, Bologna
China Medical University Hospital, Taichung
Hosp. Virgen Del Rocio, Seville
CHU Nantes - Hopital Nord Laënnec, Nantes
Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara
Meir Medical Center, Kfar Saba
Oncologianova GmbH, Recklinghausen
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola
Bethanien Krankenhaus, Moers
Inje University Haeundae Paik Hospital, Busan
Ospedale S. Maria Delle Croci, Ravenna
Henry Ford Hospital, Detroit
Rabin Medical Center, Petah Tikva
Dnipropetrovsk State Medical Academy, Dnipropetrovsk City Multifield Clinical Hospital # 4, Dnipro
Hosp. Clinico Univ. Lozano Blesa, Zaragoza
Hospital Kuala Lumpur, Kuala Lumpur
Universitaetsklinikum Koeln, Cologne
Kliniken der Stadt Koeln gGmbH, Cologne
GyeongSang National University Hospital, Gyeongsangnam-do
Oncologia Integral Satelite, Naucalpan
Sanford Health, Sioux Falls
Chonnam National University Hwasun Hospital, Jeollanam-do
CHR Hôpital Calmette, Lille
University Malaya Medical Centre, Kuala Lumpur
Washington University Medical Center, St Louis
i Can Oncology Center, Monterrey
Thoraxklinik am Universitatsklinikum Heidelberg, Heidelberg
Hospices Civils de Lyon HCL, Bron
Centre Hospitalier Le Mans, Le Mans
Onkologische Schwerpunktpraxis, Heilbronn
Institut Curie, Paris
Texas Oncology Pa, Tyler
Hospital Sultan Ismail, Johor Bahru
Asklepios Klinik Gauting GmbH - Asklepios Fachkliniken Munchen-Gauting, Gauting
Utah Cancer Specialists, Salt Lake City
Songklanagarind Hospital, Prince of Songkla University, Songkhla
UCLA, Santa Monica
City of Hope, Duarte
Shaare Zedek Medical Center, Jerusalem
University of California Irvine, Orange
HIA Begin, Saint-Mandé
Azienda Ospedaliero Univ. Policlinico Gaspare Rodolico, Catania
Providence Portland Medical Center, Portland
Zentralklinik Bad Berka GmbH, Bad Berka
Beijing Cancer Hospital, Beijing
Chinese PLA General Hospital, Beijing
Beijing Chest hospital, Capital medical university, Beijing
Peking University International Hospital, Beijing
Shengjing Hospital Of China Medical University, Shenyang
Rajiv Gandhi Cancer Institute & Research Centre, New Delhi
MCK, Moscow
Jilin cancer hospital, Changchun
Moscow City Oncology Hospital № 62, Krasnogorsk
Harbin medical university cancer hospital, Harbin
Yaroslavl Regional Clinical Oncology Hospital, Yaroslavl
Leningrad Regional Oncology Dispensary, Kuzmolovsky
Leningrad Regional Clinical Hospital, Saint Petersburg
Oncology Medical Clinics AV Medical group, Saint Petersburg
N.N. Petrov Research Institute Of Oncology, Saint Petersburg
Shanghai Chest Hospital, Shanghai
Fudan University Shanghai Cancer Center, Shanghai
Shanghai East Hospital, Shanghai
Shanghai Pulmonary Hospital, Shanghai
Nanjing Drum Tower Hospital, Nanjing
The First People's Hospital Of Changzhou, Changzhou
Hospital of Jiangnan University, Wuxi
Weifang People's Hospital, Weifang
Yantai Yuhuangding Hospital, Yantai
Tianjin Medical University General Hospital, Tianjin
The First Affiliated Hospital Zhejiang University College of Medicine, Hangzhou
The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou
Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou
Zhejiang Cancer Hospital, Hangzhou
Taizhou Hospital of Zhejiang Province, Linhai
Fujian Medical University Union Hospital, Fuzhou
City Clinical Hospital #1, Nal'chik
Tata Memorial Hospital, Mumbai
Chongqing University Cancer Hospital, Chongqing
Hunan Cancer hospital, Changsha
Noble Hospital Pvt Ltd, Pune
HCG Manavta Cancer Centre, Nashik
TongJi Hospital of TongJi Medical College of Huazhong University of Science & Technology, Wuhan
Henan Cancer Hospital, Zhengzhou
Bashkir State Medical University, Ufa
Basavatarakam Indo-American Hospital, Hyderabad
The First Affiliated Hospital Sun Yat sen University, Guangzhou
Cancer hospital Chinese Academy of Medical Sciences, Shenzhen Center, Shenzhen
Nizhny Novgorod Regional Oncological Dispensary, Nizhny Novgorod
West China Hospital Sichuan University, Chengdu
Tomsk Cancer Research Institute, Tomsk
Krasnoyarsk Regional Oncology Dispensary, Krasnoyarsk
Irkutsk Regional Oncology Dispensary, Irkutsk
Tata Medical Center, Kolkata
The First Affiliated Hospital of Xian Jiaotong University, Xi'an
Tel Aviv Sourasky Medical Center, Tel Aviv
Hadassah Medical Center, Jerusalem
Regional Cancer Care Associates LLC, East Brunswick
Fundacao Pio XII, Barretos
Cetus Oncologia, Belo Horizonte
Ynova Pesquisa Clinica, Florianópolis
Oncosite - Centro de Pesquisa Clínica em Oncologia Ltda, Ijuí
Liga Norte Riograndense Contra O Cancer, Natal
UPCO Unidade de Pesquisa Clinica em Oncologia, Pelotas
Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS, Porto Alegre
Ministerio da Saude Instituto Nacional do Cancer, Rio de Janeiro
Oncoclinicas Rio de Janeiro S A, Rio de Janeiro
Instituto D Or de Pesquisa e Ensino IDOR, Rio de Janeiro
Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo, São Paulo
Fundacao Antonio Prudente A C Camargo Cancer Center, São Paulo
Núcleo de Pesquisa São Camilo, São Paulo
IOS - Instituto de Oncologia de Sorocaba Dr. Gilson Delgado, Sorocaba
Hospital Evangélico de Cachoeiro de Itapemirim, Vitória
The Ottawa Hospital Cancer Centre, Ottawa
Sunnybrook Health Sciences Centre, Toronto
McGill University Health Centre, Montreal
Orszagos Koranyi Tbc es Pulmonologiai Intezet, Budapest
Irccs Gemelli, Roma
Juntendo University Hospital, Bunkyō City
Saitama Medical University International Medical Center, Hidaka
National Hospital Organization Himeji Medical Center, Himeji
Kansai Medical University Hospital, Hirakata
Kanazawa University Hospital, Kanazawa
National Cancer Center Hospital East, Kashiwa
Kishiwada City Hospital, Kishiwada
Kobe City Medical Center General Hospital, Kobe
Kurashiki Central Hospital, Kurashiki
Kurume University Hospital, Kurume
Matsusaka Municipal Hospital, Matsusaka
National Hospital Organization Nagoya Medical Center, Nagoya
Aichi Cancer Center Hospital, Nagoya
Niigata Cancer Center Hospital, Niigata
Kindai University Hospital, Osaka Sayama Shi
Kitasato University Hospital, Sagamihara
Hokkaido University Hospital, Sapporo
Iwate Medical University Hospital, Shiwa-gun
Shizuoka Cancer Center, Shizuoka
The Cancer Institute Hospital of JFCR, Tokyo
Ehime University Hospital, Toon-shi
Wakayama Medical University Hospital, Wakayama
National Hospital Organization Yamaguchi Ube Medical Center, Yamaguchi
Mexico Centre for Clinical Research, S.A. de C.V., Mexico City
Health Pharma Professional Research, México
Centrum Onkologii im Prof F Lukaszczyka, Bydgoszcz
Uniwersyteckie Centrum Kliniczne, Gdansk
Szpitale Pomorskie Sp z o o, Gdynia
Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie, Olsztyn
Private Specialist Hospitals - MedPolonia, Poznan
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warsaw
Hosp. Cuf Descobertas, Lisbon
Uls Sao Jose - Hosp. Sto Antonio Dos Capuchos, Lisbon
Centro Hospitalar Universitario do Porto, EPE, Porto
Instituto Portugues de Oncologia, Porto
Centro Hospitalar de Vila Nova de Gaia Espinho E P E, Vila Nova de Gaia
Pan American Center for Oncology Trials LLC, Rio Piedras
Korea University Anam Hospital, Seoul
Kangbuk Samsung Hospital, Seoul
Severance Hospital Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
The Catholic University of Korea Seoul St Mary s Hospital, Seoul
Inst. Cat. D'Oncologia-Badalona, Badalona
Hosp. de La Santa Creu I Sant Pau, Barcelona
Hosp. Univ. Quiron Dexeus, Barcelona
Hosp Univ Vall D Hebron, Barcelona
Hosp. Univ. de Burgos, Burgos
Adana City Hospital, Adana
Başkent University Medical Faculty Adana Application and Research Center, Adana
Medical Center 'Ok Clinic' of LLC 'International Institute of Clinical Studies', Kyiv
National Cancer Institute, Kyiv
Edinburgh Cancer Centre Western General, Edinburgh
The Royal Marsden NHS Trust, London
The Royal Marsden NHS Trust, Sutton
Janssen Research & Development, LLC
INDUSTRY