NCT04536805View on ClinicalTrials.gov

Relapse in Previously Irradiated Prostate Bed : Stereotactic Ablative Reirradiation Potentiated by Metformin

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

44

Participants

Timeline

Start Date

November 17, 2020

Primary Completion Date

November 30, 2028

Study Completion Date

November 30, 2030

Conditions
Prostate Cancer
Interventions
DRUG

Metformin

Metformin: 850 mg per day (day -15 to day 0) 1700 mg per day (day 1 to day 75)

RADIATION

Stereotactic Body Radiation Therapy (SBRT) 30 Gray (Gy)

Stereotactic Body Radiation Therapy (SBRT): Dose escalation 5 x 6 Gy day 0 to day 10

RADIATION

Stereotactic Body Radiation Therapy (SBRT) 36 Gy

Stereotactic Body Radiation Therapy (SBRT): Dose escalation 6 x 6 Gy day 0 to day 12

RADIATION

Stereotactic Body Radiation Therapy (SBRT) 25 Gy

Stereotactic Body Radiation Therapy (SBRT): Dose escalation 5x 5 Gy day 0 to day 10

Trial Locations (12)

21079

NOT_YET_RECRUITING

Centre GEORGES FRANCOIS LECLERC, Dijon

29200

RECRUITING

CHRU de BREST - HOPITAL MORVAN, Brest

35042

NOT_YET_RECRUITING

Centre Eugene Marquis, Rennes

37044

NOT_YET_RECRUITING

Chru Bretonneau, Tours

37170

NOT_YET_RECRUITING

Societe de Recherche Oncologique Clinique 37 (Roc 37), Chambray-lès-Tours

44805

RECRUITING

Institut de Cancerologie de L'Ouest, Saint-Herblain

49055

RECRUITING

Institut de Cancerologie de L'Ouest, Angers

59020

RECRUITING

Centre OSCAR LAMBRET, Lille

67200

RECRUITING

ICANS - Institut de cancérologie Strasbourg Europe, Strasbourg

69373

RECRUITING

Centre LEON BERARD, Lyon

72100

NOT_YET_RECRUITING

Clinique Victor Hugo, Le Mans

76038

NOT_YET_RECRUITING

Centre Henri Becquerel, Rouen

All Listed Sponsors
lead

Institut Cancerologie de l'Ouest

OTHER