Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults

PHASE3RecruitingINTERVENTIONAL
Enrollment

348

Participants

Timeline

Start Date

January 25, 2021

Primary Completion Date

July 1, 2028

Study Completion Date

July 1, 2028

Conditions
B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1
Interventions
PROCEDURE

Biospecimen Collection

Correlative studies

BIOLOGICAL

Blinatumomab

Given IV

PROCEDURE

Bone Marrow Aspiration and Biopsy

Undergo bone marrow aspiration and biopsy

DRUG

Cyclophosphamide

Given IV

DRUG

Cytarabine

Given IV or IT

DRUG

Dasatinib

Given PO

DRUG

Dexamethasone

Given PO or IV

DRUG

Doxorubicin Hydrochloride

Given IV

PROCEDURE

Echocardiography Test

Undergo ECHO

PROCEDURE

Electrocardiography

Undergo ECG

PROCEDURE

Lumbar Puncture

Undergo lumbar puncture

DRUG

Mesna

Given IV

DRUG

Methotrexate

Given IV or IT

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

DRUG

Ponatinib Hydrochloride

Given PO

DRUG

Prednisone

Given PO

DRUG

Vincristine Sulfate

Given IV

Trial Locations (209)

10467

RECRUITING

Montefiore Medical Center - Moses Campus, The Bronx

14642

RECRUITING

University of Rochester, Rochester

15232

ACTIVE_NOT_RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

17822

RECRUITING

Geisinger Medical Center, Danville

18017

RECRUITING

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

RECRUITING

Lehigh Valley Hospital-Cedar Crest, Allentown

18201

RECRUITING

Lehigh Valley Hospital-Hazleton, Hazleton

18301

RECRUITING

Pocono Medical Center, East Stroudsburg

18711

RECRUITING

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19104

RECRUITING

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

27599

RECRUITING

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27710

RECRUITING

Duke University Medical Center, Durham

29316

RECRUITING

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29425

RECRUITING

Medical University of South Carolina, Charleston

29605

RECRUITING

Prisma Health Cancer Institute - Butternut, Greenville

RECRUITING

Prisma Health Cancer Institute - Faris, Greenville

RECRUITING

Prisma Health Greenville Memorial Hospital, Greenville

29615

RECRUITING

Prisma Health Cancer Institute - Eastside, Greenville

29640

RECRUITING

Prisma Health Cancer Institute - Easley, Easley

29650

RECRUITING

Prisma Health Cancer Institute - Greer, Greer

29672

RECRUITING

Prisma Health Cancer Institute - Seneca, Seneca

30912

RECRUITING

Augusta University Medical Center, Augusta

31096

RECRUITING

Rambam Medical Center, Haifa

35233

RECRUITING

University of Alabama at Birmingham Cancer Center, Birmingham

37067

SUSPENDED

Vanderbilt-Ingram Cancer Center Cool Springs, Franklin

37204

SUSPENDED

Vanderbilt Breast Center at One Hundred Oaks, Nashville

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

38120

RECRUITING

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

38671

ACTIVE_NOT_RECRUITING

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven

40202

RECRUITING

The James Graham Brown Cancer Center at University of Louisville, Louisville

40245

RECRUITING

UofL Health Medical Center Northeast, Louisville

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

44106

RECRUITING

Case Western Reserve University, Cleveland

44109

ACTIVE_NOT_RECRUITING

MetroHealth Medical Center, Cleveland

45069

RECRUITING

University of Cincinnati Cancer Center-West Chester, West Chester

45219

RECRUITING

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

46202

RECRUITING

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

48038

RECRUITING

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48044

RECRUITING

Henry Ford Saint John Hospital - Macomb Medical, Macomb

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

RECRUITING

Huron Gastroenterology PC, Ypsilanti

48109

RECRUITING

University of Michigan Comprehensive Cancer Center, Ann Arbor

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

RECRUITING

Trinity Health Medical Center - Brighton, Brighton

48118

RECRUITING

Chelsea Hospital, Chelsea

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48126

RECRUITING

Henry Ford Medical Center-Fairlane, Dearborn

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48183

RECRUITING

Henry Ford Cancer Institute-Downriver, Brownstown

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

RECRUITING

Trinity Health Medical Center - Canton, Canton

48192

RECRUITING

Henry Ford Wyandotte Hospital, Wyandotte

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48201

RECRUITING

Wayne State University/Karmanos Cancer Institute, Detroit

48202

RECRUITING

Henry Ford Hospital, Detroit

48315

SUSPENDED

Henry Ford Macomb Health Center - Shelby Township, Shelby

48322

RECRUITING

Henry Ford West Bloomfield Hospital, West Bloomfield

48334

RECRUITING

Weisberg Cancer Treatment Center, Farmington Hills

48341

RECRUITING

Michigan Healthcare Professionals Pontiac, Pontiac

RECRUITING

Newland Medical Associates-Pontiac, Pontiac

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48346

RECRUITING

Hematology Oncology Consultants-Clarkston, Clarkston

RECRUITING

Newland Medical Associates-Clarkston, Clarkston

48377

RECRUITING

Henry Ford Medical Center-Columbus, Novi

48503

RECRUITING

Cancer Hematology Centers - Flint, Flint

SUSPENDED

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

RECRUITING

Hurley Medical Center, Flint

48601

RECRUITING

MyMichigan Medical Center Saginaw, Saginaw

48604

SUSPENDED

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48661

SUSPENDED

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch

48764

RECRUITING

MyMichigan Medical Center Tawas, Tawas City

49201

RECRUITING

Allegiance Health, Jackson

50010

RECRUITING

Mary Greeley Medical Center, Ames

RECRUITING

McFarland Clinic - Ames, Ames

50036

RECRUITING

McFarland Clinic - Boone, Boone

50129

RECRUITING

McFarland Clinic - Jefferson, Jefferson

50158

RECRUITING

McFarland Clinic - Marshalltown, Marshalltown

50501

RECRUITING

McFarland Clinic - Trinity Cancer Center, Fort Dodge

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54449

RECRUITING

Marshfield Medical Center-Marshfield, Marshfield

54476

RECRUITING

Marshfield Medical Center - Weston, Weston

54482

RECRUITING

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

RECRUITING

Marshfield Medical Center - Minocqua, Minocqua

54601

RECRUITING

Gundersen Lutheran Medical Center, La Crosse

54701

RECRUITING

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

RECRUITING

Marshfield Medical Center-Rice Lake, Rice Lake

55905

ACTIVE_NOT_RECRUITING

Mayo Clinic in Rochester, Rochester

59802

SUSPENDED

Saint Patrick Hospital - Community Hospital, Missoula

60026

ACTIVE_NOT_RECRUITING

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

ACTIVE_NOT_RECRUITING

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60045

ACTIVE_NOT_RECRUITING

Northwestern Medicine Lake Forest Hospital, Lake Forest

60153

RECRUITING

Loyola University Medical Center, Maywood

60160

SUSPENDED

Marjorie Weinberg Cancer Center at Loyola-Gottlieb, Melrose Park

60201

ACTIVE_NOT_RECRUITING

NorthShore University HealthSystem-Evanston Hospital, Evanston

60491

SUSPENDED

Loyola Medicine Homer Glen, Homer Glen

60527

SUSPENDED

Loyola Center for Health at Burr Ridge, Burr Ridge

60611

RECRUITING

Northwestern University, Chicago

62002

SUSPENDED

OSF Saint Anthony's Health Center, Alton

62864

SUSPENDED

SSM Health Good Samaritan, Mount Vernon

63011

SUSPENDED

Mercy Oncology and Hematology - Clayton-Clarkson, Ballwin

63090

SUSPENDED

Mercy Hospital Washington, Washington

63109

SUSPENDED

Mercy Infusion Center - Chippewa, St Louis

63110

RECRUITING

Washington University School of Medicine, St Louis

63128

RECRUITING

Mercy Hospital South, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

RECRUITING

Mercy Hospital Saint Louis, St Louis

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64132

ACTIVE_NOT_RECRUITING

Research Medical Center, Kansas City

64506

SUSPENDED

Heartland Regional Medical Center, Saint Joseph

64804

RECRUITING

Freeman Health System, Joplin

SUSPENDED

Mercy Hospital Joplin, Joplin

65401

SUSPENDED

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

SUSPENDED

Phelps Health Delbert Day Cancer Institute, Rolla

65613

SUSPENDED

Central Care Cancer Center - Bolivar, Bolivar

65804

SUSPENDED

Mercy Hospital Springfield, Springfield

65807

SUSPENDED

CoxHealth South Hospital, Springfield

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66205

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

66211

RECRUITING

University of Kansas Hospital-Indian Creek Campus, Overland Park

67530

SUSPENDED

Central Care Cancer Center - Great Bend, Great Bend

67846

SUSPENDED

Central Care Cancer Center - Garden City, Garden City

71103

ACTIVE_NOT_RECRUITING

LSU Health Sciences Center at Shreveport, Shreveport

72903

SUSPENDED

Mercy Hospital Fort Smith, Fort Smith

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

73120

SUSPENDED

Mercy Hospital Oklahoma City, Oklahoma City

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

RECRUITING

Houston Methodist Hospital, Houston

83301

SUSPENDED

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

SUSPENDED

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

SUSPENDED

Saint Luke's Cancer Institute - Meridian, Meridian

83687

SUSPENDED

Saint Luke's Cancer Institute - Nampa, Nampa

83712

SUSPENDED

Saint Luke's Cancer Institute - Boise, Boise

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

91010

TERMINATED

City of Hope Comprehensive Cancer Center, Duarte

91031

RECRUITING

Shaare Zedek Medical Center, Jerusalem

91505

SUSPENDED

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92093

SUSPENDED

UC San Diego Moores Cancer Center, La Jolla

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

93611

RECRUITING

Community Cancer Institute, Clovis

SUSPENDED

University Oncology Associates, Clovis

96701

RECRUITING

Hawaii Cancer Care - Westridge, ‘Aiea

RECRUITING

Pali Momi Medical Center, ‘Aiea

SUSPENDED

Queen's Cancer Center - Pearlridge, ‘Aiea

SUSPENDED

The Cancer Center of Hawaii-Pali Momi, ‘Aiea

96766

SUSPENDED

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue

96813

RECRUITING

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

SUSPENDED

Queen's Cancer Cenrer - POB I, Honolulu

SUSPENDED

Queen's Medical Center, Honolulu

RECRUITING

Straub Clinic and Hospital, Honolulu

SUSPENDED

University of Hawaii Cancer Center, Honolulu

96817

SUSPENDED

Hawaii Cancer Care Inc-Liliha, Honolulu

SUSPENDED

Kuakini Medical Center, Honolulu

SUSPENDED

Queen's Cancer Center - Kuakini, Honolulu

SUSPENDED

The Cancer Center of Hawaii-Liliha, Honolulu

96826

RECRUITING

Kapiolani Medical Center for Women and Children, Honolulu

97015

SUSPENDED

Clackamas Radiation Oncology Center, Clackamas

SUSPENDED

Providence Cancer Institute Clackamas Clinic, Clackamas

97045

RECRUITING

Providence Willamette Falls Medical Center, Oregon City

97132

RECRUITING

Providence Newberg Medical Center, Newberg

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence Saint Vincent Medical Center, Portland

97420

SUSPENDED

Bay Area Hospital, Coos Bay

97701

SUSPENDED

Saint Charles Health System, Bend

97756

SUSPENDED

Saint Charles Health System-Redmond, Redmond

98026

SUSPENDED

Swedish Cancer Institute-Edmonds, Edmonds

98029

SUSPENDED

Swedish Cancer Institute-Issaquah, Issaquah

98104

SUSPENDED

Pacific Gynecology Specialists, Seattle

98107

SUSPENDED

Swedish Medical Center-Ballard Campus, Seattle

98122

SUSPENDED

Swedish Medical Center-First Hill, Seattle

98201

SUSPENDED

Providence Regional Cancer Partnership, Everett

98225

SUSPENDED

PeaceHealth Saint Joseph Medical Center, Bellingham

98284

SUSPENDED

PeaceHealth United General Medical Center, Sedro-Woolley

98503

SUSPENDED

Providence Regional Cancer System-Lacey, Lacey

98508

SUSPENDED

Anchorage Associates in Radiation Medicine, Anchorage

98520

SUSPENDED

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

SUSPENDED

Providence Regional Cancer System-Centralia, Centralia

98584

SUSPENDED

Providence Regional Cancer System-Shelton, Shelton

98597

SUSPENDED

Providence Regional Cancer System-Yelm, Yelm

98632

SUSPENDED

PeaceHealth Saint John Medical Center, Longview

98664

RECRUITING

PeaceHealth Southwest Medical Center, Vancouver

99336

RECRUITING

Kadlec Clinic Hematology and Oncology, Kennewick

99362

SUSPENDED

Providence Saint Mary Regional Cancer Center, Walla Walla

99504

SUSPENDED

Anchorage Radiation Therapy Center, Anchorage

99508

SUSPENDED

Alaska Breast Care and Surgery LLC, Anchorage

SUSPENDED

Alaska Oncology and Hematology LLC, Anchorage

SUSPENDED

Alaska Women's Cancer Care, Anchorage

SUSPENDED

Anchorage Oncology Centre, Anchorage

SUSPENDED

Katmai Oncology Group, Anchorage

SUSPENDED

Providence Alaska Medical Center, Anchorage

06520

RECRUITING

Yale University, New Haven

20889-5600

RECRUITING

Walter Reed National Military Medical Center, Bethesda

07740

RECRUITING

Monmouth Medical Center, Long Branch

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

05401

RECRUITING

University of Vermont Medical Center, Burlington

05405

RECRUITING

University of Vermont and State Agricultural College, Burlington

98122-5711

SUSPENDED

Swedish Medical Center-Cherry Hill, Seattle

00927

RECRUITING

Centro Comprensivo de Cancer de UPR, San Juan

00936

RECRUITING

San Juan City Hospital, San Juan

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH