A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

611

Participants

Timeline

Start Date

October 8, 2020

Primary Completion Date

February 1, 2027

Study Completion Date

February 1, 2027

Conditions
Diffuse Large B-Cell Lymphoma
Interventions
DRUG

acalabrutinib

Investigational Product

DRUG

placebo

Placebo comparator

DRUG

Prednisone

Investigational Product

DRUG

Rituximab

Investigational Product

DRUG

Cyclophosphamide

Investigational Product

DRUG

Vincristine

Investigational Product

DRUG

Doxorubicin

Investigational Product

Trial Locations (255)

100

Research Site, Taipei

235

Research Site, Taipei

736

Research Site, Tainan City

833

Research Site, Kaohsiung City

2010

Research Site, Darlinghurst

2050

Research Site, Camperdown

2060

Research Site, Antwerp

2145

Research Site, Westmead

2170

Research Site, Liverpool

2217

Research Site, Kogarah

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Research Site, Heidelberg

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Research Site, Clayton

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Research Site, Linz

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5000

Research Site, Adelaide

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6009

Research Site, Nedlands

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Research Site, Hobart

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10028

Research Site, New York

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Research Site, New York

10126

Research Site, Torino

10408

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10967

Research Site, Berlin

11795

Research Site, Stony Brook

12208

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13385

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14033

Research Site, Caen

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18009

Research Site, Cherkasy

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Research Site, Philadelphia

20141

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20162

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28033

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29000

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31000

Research Site, Chihuahua City

31008

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31100

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100191

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Research Site, Delhi

110042

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130021

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150081

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194291

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197022

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215006

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250117

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300020

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310003

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310009

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330006

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450008

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454087

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471003

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510060

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510080

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510120

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530021

Research Site, Nanning

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Research Site, Bangalore

610041

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Research Site, Kochi

4941492

Research Site, Petah Tikva

6423906

Research Site, Tel Aviv

7747629

Research Site, Ashdod

8410101

Research Site, Beersheba

07198

Research Site, Palma

Unknown

Research Site, Taipei

Research Site, Taoyuan

Research Site, Shanghai

06700

Research Site, Ankara

03022

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04112

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06360

Research Site, Norwich

33705-1449

Research Site, St. Petersburg

32308-5304

Research Site, Tallahassee

81520-060

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88034-000

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74605-020

Research Site, Goiânia

99010-260

Research Site, Passo Fundo

90035-003

Research Site, Porto Alegre

90110-270

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90619-900

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14051-140

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22793-080

Research Site, Rio de Janeiro

01236-030

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01323-001

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01509-900

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04029-000

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05652-900

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08270-070

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13083-878

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V5Z 4E6

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M5G 2M9

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R3E 0V9

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N6A 5W9

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G6V 0B8

Research Site, Lévis

H1T 2M4

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H2X 3E4

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G1J 1Z4

Research Site, Québec

K1H 8L6

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M4N 3M5

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050020

Research Site, Shijiazhuang

625 00

Research Site, Brno

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Research Site, Hradec Králové

708 52

Research Site, Ostrava - Poruba

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Research Site, Pilsen

100 34

Research Site, Prague

128 08

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01307

Research Site, Dresden

400 012

Research Site, Mumbai

00144

Research Site, Roma

00152

Research Site, Roma

260-8717

Research Site, Chiba

104-0045

Research Site, Chūōku

812-8582

Research Site, Fukuoka

173-8610

Research Site, Itabashi-ku

920-0293

Research Site, Kahoku-gun

277-8577

Research Site, Kashiwa

650-0047

Research Site, Kobe

135-8550

Research Site, Kōtoku

860-0008

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860-8556

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602-8026

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791-0280

Research Site, Matsuyama

852-8501

Research Site, Nagasaki

460-0001

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466-8560

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951-8520

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700-8558

Research Site, Okayama

545-8586

Research Site, Osaka

003-0006

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980-8574

Research Site, Sendai

329-0498

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514-8507

Research Site, Tsu

80-952

Research Site, Gdansk

30-510

Research Site, Krakow

93-513

Research Site, Lodz

20-081

Research Site, Lublin

02-776

Research Site, Warsaw

50-367

Research Site, Wroclaw

1400-038

Research Site, Lisbon

1649-035

Research Site, Lisbon

1998-018

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4454-509

Research Site, Matosinhos Municipality

4099-001

Research Site, Porto

4200-319

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4434-502

Research Site, Vila Nova de Gaia

03080

Research Site, Seoul

03722

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06591

Research Site, Seoul

08003

Research Site, Barcelona

08035

Research Site, Barcelona

08908

Research Site, L'Hospitalet de Llobregat

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Acerta Pharma BV

INDUSTRY